HitPredict

Interactor 1: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1

Interactor 2: NAL10 (Q86W26)
NACHT, LRR and PYD domains-containing protein 10 (Nucleotide-binding oligomerization domain protein 8)
Gene: NLRP10

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15096476
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0050729 - positive regulation of inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 404 Hs			1 655
+	Hs
		667484 CASP1_HUMAN (1-404): 0: 514: 100.00		NLRP3_HUMAN (5-601): 0: 635: 32.60
+	Mm
		667128 CASP1_MOUSE (1-404): 1.52e-165: 471: 62.13		NLRP3_MOUSE (6-631): 0: 631: 31.42
+	Hs
		667493 CASP1_HUMAN (1-404): 0: 514: 100.00		NALP2_HUMAN (3-631): 0: 584: 23.65
+	Hs
		667480 CASP1_HUMAN (1-404): 0: 514: 100.00		NALP7_HUMAN (13-601): 0: 578: 27.77
+	Hs
		667448 CASP1_HUMAN (1-404): 0: 514: 100.00		NLRP6_HUMAN (21-599): 4.18e-160: 484: 26.87
+	Hs
		667501 CASP1_HUMAN (1-404): 0: 514: 100.00		NOD1_HUMAN (49-608): 5.09e-120: 381: 17.80
+	Hs
		667490 CASP1_HUMAN (1-404): 0: 514: 100.00		NOD2_HUMAN (51-605): 1.84e-116: 374: 19.69
+	Mm
		667127 CASP1_MOUSE (1-404): 1.52e-165: 471: 62.13		NOD2_MOUSE (51-605): 2.97e-114: 368: 18.81
+	Hs
		667491 CASP1_HUMAN (1-404): 0: 514: 100.00		NLRC4_HUMAN (77-611): 2.51e-97: 323: 16.24
+	Hs
		830305 CASP4_HUMAN (1-404): 6.94e-153: 438: 48.40		NOD1_HUMAN (49-608): 5.09e-120: 381: 17.80
+	Hs
		830296 CASP4_HUMAN (1-404): 6.94e-153: 438: 48.40		NOD2_HUMAN (51-605): 1.84e-116: 374: 19.69
+	Mm
		667124 CASP1_MOUSE (1-404): 1.52e-165: 471: 62.13		NLRC4_MOUSE (77-611): 9.75e-86: 291: 14.57
+	Hs
		876977 CASP9_HUMAN (17-399): 9.64e-122: 360: 22.98		BIRC1_HUMAN (93-564): 8.26e-83: 286: 17.66
+	Hs
		183325 CASP1_HUMAN (1-404): 0: 514: 100.00		MEFV_HUMAN (6-102): 2.59e-20: 97.9: 29.90
+	Hs
		667487 CASP1_HUMAN (1-404): 0: 514: 100.00		NLRP1_HUMAN (13-102): 2.46e-15: 82.1: 22.22
+	Hs
		667498 CASP1_HUMAN (1-404): 0: 514: 100.00		ASC_HUMAN (6-91): 3.61e-14: 73.6: 32.56
+	Mm
		667129 CASP1_MOUSE (1-404): 1.52e-165: 471: 62.13		ASC_MOUSE (6-141): 2.19e-25: 105: 23.53
+	Hs
		183326 CASP5_HUMAN (5-404): 1.04e-145: 422: 46.25		MEFV_HUMAN (6-102): 2.59e-20: 97.9: 29.90
+	Hs
		851077 CASP5_HUMAN (5-404): 1.04e-145: 422: 46.25		NLRP1_HUMAN (13-102): 2.46e-15: 82.1: 22.22
+	Hs
		877001 CASP9_HUMAN (17-399): 9.64e-122: 360: 22.98		NLRP1_HUMAN (13-102): 2.46e-15: 82.1: 22.22