Protein: RPC5
DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide)

Gene: RPC5, POLR3E
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q9NVU0

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005666 - RNA polymerase III complex
GO:0005829 - cytosol
GO:0006351 - DNA-templated transcription
GO:0045087 - innate immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

430652

RPC4
DNA-directed RNA polymerase III subunit RPC4

8

4

Small-scale

0.972

High

1450818

RPC2
DNA-directed RNA polymerase III subunit RPC2

7

3

Small-scale

0.963

High

1450829

RPC10
DNA-directed RNA polymerase III subunit RPC10

6

3

High-throughput

0.949

High

180414

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

5

3

High-throughput

0.932

High

1431036

RPC6
DNA-directed RNA polymerase III subunit RPC6

5

1

High-throughput

0.930

High

983717

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

4

1

High-throughput

0.892

High

165099

RPC1
DNA-directed RNA polymerase III subunit RPC1

7

3

Small-scale

0.749

High

1450831

RPC8
DNA-directed RNA polymerase III subunit RPC8

8

2

High-throughput

0.749

High

287488

RPC9
DNA-directed RNA polymerase III subunit RPC9

6

1

High-throughput

0.735

High

186384

RPC7
DNA-directed RNA polymerase III subunit RPC7

6

2

Small-scale

0.732

High

621988

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

5

1

High-throughput

0.725

High

1413120

RPC7L
DNA-directed RNA polymerase III subunit RPC7-like

5

2

High-throughput

0.720

High

1414279

RPC3
DNA-directed RNA polymerase III subunit RPC3

5

1

High-throughput

0.720

High

959072

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

4

1

High-throughput

0.699

High

786881

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

3

1

High-throughput

0.667

High

923553

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

3

1

High-throughput

0.667

High

967998

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

3

1

High-throughput

0.667

High

1439334

GPN1
GPN-loop GTPase 1

3

1

High-throughput

0.667

High

316450

RMP
Unconventional prefoldin RPB5 interactor 1

4

0

Small-scale

0.664

High

912138

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

2

High-throughput

0.656

High

1450826

GPN3
GPN-loop GTPase 3

5

1

High-throughput

0.654

High

1435180

RPAP3
RNA polymerase II-associated protein 3

3

0

High-throughput

0.638

High

1450822

UXT
Protein UXT

3

0

High-throughput

0.638

High

64440

BDP1
Transcription factor TFIIIB component B'' homolog

2

1

High-throughput

0.628

High

227032

MCAT
Mitochondrial carnitine/acylcarnitine carrier protein

2

2

High-throughput

0.628

High

1429445

MAF1
Repressor of RNA polymerase III transcription MAF1 homolog

2

1

High-throughput

0.628

High

621767

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.618

High

723114

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

3

High-throughput

0.618

High

787798

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

3

High-throughput

0.618

High

1437314

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

3

High-throughput

0.618

High

516877

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

3

2

High-throughput

0.611

High

1336351

GIMA8
GTPase IMAP family member 8

2

0

High-throughput

0.602

High

1450832

TF3C3
General transcription factor 3C polypeptide 3

2

0

High-throughput

0.602

High

1450825

PFD2
Prefoldin subunit 2

2

0

High-throughput

0.585

High

332250

UCP5
Brain mitochondrial carrier protein 1

2

1

High-throughput

0.574

High

1257829

ACD11
Acyl-CoA dehydrogenase family member 11

2

1

High-throughput

0.574

High

1313061

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

0

High-throughput

0.559

High

625659

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.536

High

998060

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.536

High

1065461

SSRP1
FACT complex subunit SSRP1

1

2

Small-scale

0.536

High

1371358

TF3B
Transcription factor IIIB 90 kDa subunit

1

2

High-throughput

0.536

High

337497

PSMG1
Proteasome assembly chaperone 1

1

0

High-throughput

0.513

High

337619

FMNL1
Formin-like protein 1

1

0

High-throughput

0.513

High

478226

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

716635

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

0

High-throughput

0.513

High

852055

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.513

High

914129

HXK2
Hexokinase-2

1

0

High-throughput

0.513

High

984305

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.513

High

997157

TBA4A
Tubulin alpha-4A chain

1

0

High-throughput

0.513

High

1054656

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.513

High

1121537

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.513

High

1270341

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.513

High

1292976

AROS
Active regulator of SIRT1

1

0

High-throughput

0.513

High

1382543

TRI52
E3 ubiquitin-protein ligase TRIM52

1

0

High-throughput

0.513

High

1450827

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

1450828

RUVB2
RuvB-like 2

1

0

High-throughput

0.513

High

1450830

TPRKB
EKC/KEOPS complex subunit TPRKB

1

0

High-throughput

0.513

High

863001

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.493

High

552414

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.489

High

1438538

TPC
Mitochondrial thiamine pyrophosphate carrier

1

2

High-throughput

0.489

High

340043

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

3

High-throughput

0.479

High

667478

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

High-throughput

0.479

High

912246

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

2

High-throughput

0.479

High

976161

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

2

High-throughput

0.479

High

980425

H4
Histone H4

1

1

High-throughput

0.479

High

1054796

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.479

High

1217623

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

2

High-throughput

0.479

High

1399365

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

2

High-throughput

0.479

High

1447086

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

2

High-throughput

0.479

High

1450820

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

3

High-throughput

0.479

High

191124

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

192868

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.458

High

243095

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

589840

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

613203

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

1007793

RAE1L
mRNA export factor RAE1

1

0

High-throughput

0.458

High

1401412

CIC
Protein capicua homolog

1

0

High-throughput

0.458

High

1428646

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1446521

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

1450823

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1450824

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.458

High

91737

C9JLU1
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

2

High-throughput

0.445

High

94360

D6R9U7
RNA polymerase III subunit G

1

2

High-throughput

0.445

High

1421364

S39A8
Metal cation symporter ZIP8

1

1

High-throughput

0.445

High

132926

S28A1
Sodium/nucleoside cotransporter 1

1

0

High-throughput

0.426

High

516807

RPC22
Protein POLR1D, isoform 2

1

0

High-throughput

0.426

High

664907

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

0

High-throughput

0.426

High

1326114

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

1382785

FERM2
Fermitin family homolog 2

1

0

High-throughput

0.426

High

1404447

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.426

High

1251811

S39A5
Zinc transporter ZIP5

1

1

High-throughput

0.407

High

1450819

PIHD1
PIH1 domain-containing protein 1

5

0

High-throughput

0.374

High

1398617

DAA10
Dynein axonemal assembly factor 10

3

0

High-throughput

0.347

High

426002

CP2E1
Cytochrome P450 2E1

2

0

High-throughput

0.328

High

182194

PFD6
Prefoldin subunit 6

2

0

High-throughput

0.318

High

1449777

PDRG1
p53 and DNA damage-regulated protein 1

2

0

High-throughput

0.318

High

389610

RET4
Retinol-binding protein 4

1

0

High-throughput

0.279

Low

471281

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.279

Low

541131

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1275505

TRM1L
tRNA

1

0

High-throughput

0.279

Low

1356738

TM263
Transmembrane protein 263

1

0

High-throughput

0.279

Low

1359546

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.279

Low

1450821

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.279

Low

1232028

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

1255784

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1434036

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025