HitPredict

Interactor 1: PML (P29590)
Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)
Gene: PML

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.758

The method score is based on:

Property	Details
Experiments	15195100, 14507915, 12759344, 19150978, 20972456, 22869143, 23169665, 12915590
Identification Methods	affinity chromatography technology, pull down, enzymatic study, coimmunoprecipitation, anti bait coimmunoprecipitation, imaging technique
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0005829 - cytosol and 11 others more... GO:0006915 - apoptotic process GO:0006977 - DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0008270 - zinc ion binding GO:0016925 - protein sumoylation GO:0019789 - SUMO transferase activity GO:0031625 - ubiquitin protein ligase binding GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0045892 - negative regulation of DNA-templated transcription GO:0051726 - regulation of cell cycle GO:0061630 - ubiquitin protein ligase activity GO:0065003 - protein-containing complex assembly
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	882
Hs

1	491

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024