HitPredict

Interactor 1: TYK2 (P29597)
Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)
Gene: TYK2

Interactor 2: HAVR2 (Q8TDQ0)
Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
Gene: HAVCR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0032729 - positive regulation of type II interferon production GO:0042102 - positive regulation of T cell proliferation
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1187 Hs			1 301
+	Hs
		412276 FYN_HUMAN (813-1182): 7.36e-96: 318: 26.54		HAVR2_HUMAN (1-301): 0: 542: 100.00
+	Hs
		411802 LCK_HUMAN (879-1183): 1.61e-95: 316: 31.09		HAVR2_HUMAN (1-301): 0: 542: 100.00
+	Hs
		616843 JAK1_HUMAN (852-1178): 1.14e-34: 146: 19.54		HAVR2_HUMAN (1-301): 0: 542: 100.00
+	Hs
		412298 FYN_HUMAN (813-1182): 7.36e-96: 318: 26.54		HAVR1_HUMAN (10-133): 2.47e-51: 174: 40.95