Protein: OPRX
Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor)

Gene: OPRX, OPRL1
Organism: Homo sapiens
Interactions: 96
UniProt ID: P41146

Gene Ontology (top 5):
GO:0001626 - nociceptin receptor activity
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane
GO:0007193 - adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007200 - phospholipase C-activating G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

770828

OPRM
Mu-type opioid receptor

1

13

Small-scale

0.724

High

832427

WDFY3
WD repeat and FYVE domain-containing protein 3

1

0

High-throughput

0.656

High

832401

PNOC
Prepronociceptin [Cleaved into: Nocistatin; Nociceptin

3

1

Small-scale

0.651

High

755527

TTK
Dual specificity protein kinase TTK

1

5

High-throughput

0.618

High

832422

CERS6
Ceramide synthase 6

2

5

High-throughput

0.591

High

520768

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.541

High

832454

PLLP
Plasmolipin

1

4

High-throughput

0.541

High

133456

ACATN
Acetyl-coenzyme A transporter 1

1

1

High-throughput

0.536

High

163253

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

3

High-throughput

0.536

High

178616

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

2

High-throughput

0.536

High

186410

TM9S1
Transmembrane 9 superfamily member 1

1

4

High-throughput

0.536

High

190591

MRP4
ATP-binding cassette sub-family C member 4

1

2

High-throughput

0.536

High

249438

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

2

High-throughput

0.536

High

252663

TSN3
Tetraspanin-3

1

10

High-throughput

0.536

High

255999

S19A2
Thiamine transporter 1

1

2

High-throughput

0.536

High

332205

UCP5
Brain mitochondrial carrier protein 1

1

12

High-throughput

0.536

High

443696

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

6

High-throughput

0.536

High

565570

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

17

High-throughput

0.536

High

624606

SL9A1
Sodium/hydrogen exchanger 1

1

2

High-throughput

0.536

High

661233

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

20

High-throughput

0.536

High

680258

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

6

High-throughput

0.536

High

832391

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

1

High-throughput

0.536

High

832393

KNTC1
Kinetochore-associated protein 1

1

1

High-throughput

0.536

High

832394

AT12A
Potassium-transporting ATPase alpha chain 2

1

16

High-throughput

0.536

High

832395

ACTB
Actin, cytoplasmic 1

1

6

High-throughput

0.536

High

832397

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

20

High-throughput

0.536

High

832398

S20A2
Sodium-dependent phosphate transporter 2

1

1

High-throughput

0.536

High

832403

AT2B3
Plasma membrane calcium-transporting ATPase 3

1

20

High-throughput

0.536

High

832410

MRP7
ATP-binding cassette sub-family C member 10

1

3

High-throughput

0.536

High

832412

AB17B
Alpha/beta hydrolase domain-containing protein 17B

1

9

High-throughput

0.536

High

832413

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

5

High-throughput

0.536

High

832417

MFS12
Major facilitator superfamily domain-containing protein 12

1

2

High-throughput

0.536

High

832437

PAQR1
Adiponectin receptor protein 1

1

1

High-throughput

0.536

High

832439

RB39B
Ras-related protein Rab-39B

1

8

High-throughput

0.536

High

832456

ENPP4
Bis(5'-adenosyl)-triphosphatase ENPP4

1

5

High-throughput

0.536

High

190546

COPT2
Protein SLC31A2

1

0

High-throughput

0.518

High

832392

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

832399

CLN3
Battenin

1

0

High-throughput

0.513

High

832434

SPPL3
Signal peptide peptidase-like 3

1

0

High-throughput

0.513

High

832444

P2RX4
P2X purinoceptor 4

1

0

High-throughput

0.513

High

832442

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

1

High-throughput

0.494

High

66152

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

2

High-throughput

0.489

High

67359

RTL8C
Retrotransposon Gag-like protein 8C

1

2

High-throughput

0.489

High

173673

BTAF1
TATA-binding protein-associated factor 172

1

3

High-throughput

0.489

High

223709

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

1

High-throughput

0.489

High

248566

FADS1
Acyl-CoA

1

3

High-throughput

0.489

High

665537

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

2

High-throughput

0.489

High

784534

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

1

High-throughput

0.489

High

832396

TBA4A
Tubulin alpha-4A chain

1

5

High-throughput

0.489

High

832400

MTX1
Metaxin-1

1

4

High-throughput

0.489

High

832404

SIA4B
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

1

1

High-throughput

0.489

High

832405

TBB8
Tubulin beta-8 chain

1

10

High-throughput

0.489

High

832406

ORML2
ORM1-like protein 2

1

2

High-throughput

0.489

High

832407

ACTBL
Beta-actin-like protein 2

1

6

High-throughput

0.489

High

832409

KMCP1
Kidney mitochondrial carrier protein 1

1

12

High-throughput

0.489

High

832411

TM164
Transmembrane protein 164

1

1

High-throughput

0.489

High

832414

ACD10
Acyl-CoA dehydrogenase family member 10

1

3

High-throughput

0.489

High

832415

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

10

High-throughput

0.489

High

832416

RINT1
RAD50-interacting protein 1

1

2

High-throughput

0.489

High

832418

MBOA5
Lysophospholipid acyltransferase 5

1

5

High-throughput

0.489

High

832419

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

2

High-throughput

0.489

High

832420

HACD2
Very-long-chain

1

2

High-throughput

0.489

High

832421

THADA
tRNA

1

2

High-throughput

0.489

High

832423

DYM
Dymeclin

1

3

High-throughput

0.489

High

832424

ADCK1
AarF domain-containing protein kinase 1

1

5

High-throughput

0.489

High

832425

T126B
Complex I assembly factor TMEM126B, mitochondrial

1

2

High-throughput

0.489

High

832426

S35F2
Solute carrier family 35 member F2

1

2

High-throughput

0.489

High

832428

INT1
Integrator complex subunit 1

1

4

High-throughput

0.489

High

832429

F241A
Uncharacterized protein FAM241A

1

1

High-throughput

0.489

High

832430

NAV1
Neuron navigator 1

1

3

High-throughput

0.489

High

832431

ATLA2
Atlastin-2

1

7

High-throughput

0.489

High

832432

MFSD8
Major facilitator superfamily domain-containing protein 8

1

9

High-throughput

0.489

High

832435

CHPT1
Cholinephosphotransferase 1

1

2

High-throughput

0.489

High

832436

LGAT1
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

1

5

High-throughput

0.489

High

832438

TM186
Transmembrane protein 186

1

1

High-throughput

0.489

High

832441

CERS2
Ceramide synthase 2

1

5

High-throughput

0.489

High

832443

TLCD4
TLC domain-containing protein 4

1

1

High-throughput

0.489

High

832445

TBA1C
Tubulin alpha-1C chain

1

7

High-throughput

0.489

High

832446

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

1

High-throughput

0.489

High

832447

PTSS2
Phosphatidylserine synthase 2

1

2

High-throughput

0.489

High

832449

TM9S3
Transmembrane 9 superfamily member 3

1

4

High-throughput

0.489

High

832450

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

6

High-throughput

0.489

High

832451

MTFP1
Mitochondrial fission process protein 1

1

1

High-throughput

0.489

High

832452

GCP4
Gamma-tubulin complex component 4

1

7

High-throughput

0.489

High

832453

MGT4B
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

1

1

High-throughput

0.489

High

832455

PEX16
Peroxisomal membrane protein PEX16

1

1

High-throughput

0.489

High

832408

GASP1
G-protein coupled receptor-associated sorting protein 1

1

6

Small-scale

0.457

High

832448

ACTBM
Putative beta-actin-like protein 3

1

6

High-throughput

0.407

High

223606

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.279

Low

298682

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

0

High-throughput

0.279

Low

299623

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

0

High-throughput

0.279

Low

397791

ATP8
ATP synthase F(0) complex subunit 8

1

0

High-throughput

0.279

Low

832402

STAR3
StAR-related lipid transfer protein 3

1

0

High-throughput

0.279

Low

832433

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.279

Low

832440

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.279

Low

515680

TPC2B
Trafficking protein particle complex subunit 2B

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025