HitPredict

Interactor 1: MARCS (P29966)
Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
Gene: MARCKS

Interactor 2: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	26598620, 31871319
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007015 - actin filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 332 Hs			1 258
+	Hs
		436170 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		670162 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RHOV_HUMAN (49-258): 3.82e-87: 260: 60.66
+	Hs
		669952 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		669979 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		669967 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RAB1A_HUMAN (39-256): 5.65e-82: 246: 21.92
+	Hs
		166039 SYNJ2_HUMAN (63-316): 5.31e-21: 96: 9.20		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		297809 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		669970 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		166043 SYNJ2_HUMAN (63-316): 5.31e-21: 96: 9.20		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		669965 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		669956 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		545219 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		297819 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		669953 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		297827 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		297823 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		297820 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		297812 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		564421 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		670213 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26