Protein: DPOE3
DNA polymerase epsilon subunit 3 (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17)

Gene: DPOE3, POLE3
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q9NRF9

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003887 - DNA-directed DNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005721 - pericentric heterochromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1448440

CHRC1
Chromatin accessibility complex protein 1

6

20

Small-scale

0.958

High

1133363

NC2A
Dr1-associated corepressor

5

20

High-throughput

0.937

High

1031960

NC2B
Protein Dr1

5

10

High-throughput

0.924

High

1447933

DPOE4
DNA polymerase epsilon subunit 4

4

20

Small-scale

0.902

High

243744

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

5

4

Small-scale

0.721

High

1448441

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

4

12

Small-scale

0.692

High

1163230

H2B2E
Histone H2B type 2-E

1

5

High-throughput

0.691

High

1060496

DPOE1
DNA polymerase epsilon catalytic subunit A

4

2

Small-scale

0.691

High

940506

DPOE2
DNA polymerase epsilon subunit 2

3

1

Small-scale

0.689

High

1225879

Q658N3
Protein Dr1

1

10

High-throughput

0.665

High

703385

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

2

4

High-throughput

0.628

High

755000

H2B1B
Histone H2B type 1-B

1

5

High-throughput

0.618

High

290990

PPM1B
Protein phosphatase 1B

1

1

High-throughput

0.536

High

340414

YETS4
YEATS domain-containing protein 4

1

4

High-throughput

0.536

High

1065448

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

1104331

ORC1
Origin recognition complex subunit 1

1

2

High-throughput

0.536

High

1357989

RN138
E3 ubiquitin-protein ligase RNF138

1

1

High-throughput

0.536

High

1418005

GNB1L
Guanine nucleotide-binding protein subunit beta-like protein 1

1

3

High-throughput

0.536

High

601872

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

1334327

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.513

High

1431062

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.513

High

1208381

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

3

High-throughput

0.489

High

1395960

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.489

High

260503

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

298629

RAD17
Cell cycle checkpoint protein RAD17

1

2

Small-scale

0.479

High

607142

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

941067

HDAC4
Histone deacetylase 4

1

2

High-throughput

0.479

High

980396

H4
Histone H4

1

3

High-throughput

0.479

High

1448444

YETS2
YEATS domain-containing protein 2

1

5

Small-scale

0.479

High

316051

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

559516

XRCC5
X-ray repair cross-complementing protein 5

1

0

Small-scale

0.458

High

1135822

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1280533

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1364613

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1435338

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1448443

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

423268

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.457

High

215758

ERI3
ERI1 exoribonuclease 3

1

0

High-throughput

0.279

Low

269470

KI21B
Kinesin-like protein KIF21B

1

0

High-throughput

0.279

Low

956615

RAB5B
Ras-related protein Rab-5B

1

0

High-throughput

0.279

Low

982133

RAP1A
Ras-related protein Rap-1A

1

0

High-throughput

0.279

Low

1242048

SCYL2
SCY1-like protein 2

1

0

High-throughput

0.279

Low

1290048

PNM8A
Paraneoplastic antigen-like protein 8A

1

0

High-throughput

0.279

Low

1323627

LRC47
Leucine-rich repeat-containing protein 47

1

0

High-throughput

0.279

Low

1439643

CHM1A
Charged multivesicular body protein 1a

1

0

High-throughput

0.279

Low

1448442

GDAP2
Ganglioside-induced differentiation-associated protein 2

1

0

High-throughput

0.279

Low

1255697

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025