HitPredict

Interactor 1: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Interactor 2: H2AW (Q9P0M6)
Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)
Gene: MACROH2A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 801 Hs			1 372
+	Hs
		277561 BRD2_HUMAN (1-773): 1.65e-170: 514: 100.00		H2AY_HUMAN (1-371): 8.22e-156: 444: 66.31
+	Hs
		277694 BRD3_HUMAN (53-764): 8.33e-122: 384: 56.56		H2AY_HUMAN (1-371): 8.22e-156: 444: 66.31
+	Hs
		1141339 BRD3_HUMAN (53-764): 8.33e-122: 384: 56.56		H2AW_HUMAN (1-372): 5.29e-152: 434: 100.00
+	Hs
		591483 BRD2_HUMAN (1-773): 1.65e-170: 514: 100.00		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		674232 BRD2_HUMAN (1-773): 1.65e-170: 514: 100.00		H2A2B_HUMAN (1-123): 1.25e-64: 203: 63.49
+	Hs
		418840 BRD2_HUMAN (1-773): 1.65e-170: 514: 100.00		H2A1B_HUMAN (1-126): 6.68e-64: 201: 60.47
+	Hs
		591655 BRD3_HUMAN (53-764): 8.33e-122: 384: 56.56		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		1141205 BRD3_HUMAN (53-764): 8.33e-122: 384: 56.56		H2A2B_HUMAN (1-123): 1.25e-64: 203: 63.49
+	Hs
		1141145 BRD3_HUMAN (53-764): 8.33e-122: 384: 56.56		H2A2C_HUMAN (1-126): 7.61e-64: 201: 61.24
+	Hs
		1141172 BRD3_HUMAN (53-764): 8.33e-122: 384: 56.56		H2A2A_HUMAN (1-126): 4.29e-64: 201: 62.02
+	Hs
		591615 EP300_HUMAN (31-183): 5.55e-39: 159: 30.72		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Mm
		74291 EP300_MOUSE (202-448): 1.27e-40: 164: 24.71		H2A3_MOUSE (1-126): 5.32e-64: 201: 61.24
+	Hs
		1067488 EP300_HUMAN (31-183): 5.55e-39: 159: 30.72		H2A2B_HUMAN (1-123): 1.25e-64: 203: 63.49
+	Hs
		1067402 EP300_HUMAN (31-183): 5.55e-39: 159: 30.72		H2A2C_HUMAN (1-126): 7.61e-64: 201: 61.24
+	Hs
		418957 EP300_HUMAN (31-183): 5.55e-39: 159: 30.72		H2A1B_HUMAN (1-126): 6.68e-64: 201: 60.47
+	Mm
		1233106 KAT2B_MOUSE (293-452): 3.2e-32: 136: 25.00		H2A2A_MOUSE (1-126): 4.29e-64: 201: 62.02
+	Sc
		419817 RSC1_YEAST (75-483): 2.91e-40: 161: 16.55		H2A2_YEAST (14-124): 2.56e-41: 143: 65.77
+	Sc
		419493 GCN5_YEAST (275-456): 3e-40: 155: 26.63		H2A1_YEAST (14-125): 3.17e-41: 143: 65.79
+	Sc
		419853 GCN5_YEAST (275-456): 3e-40: 155: 26.63		H2A2_YEAST (14-124): 2.56e-41: 143: 65.77
+	At
		307557 GCN5_ARATH (351-449): 7.84e-33: 136: 37.62		H2A3_ARATH (1-125): 1.06e-39: 139: 62.31