HitPredict

Interactor 1: GDIA (P31150)
Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (Oligophrenin-2) (Protein XAP-4)
Gene: GDI1

Interactor 2: RAB8A (P61006)
Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)
Gene: RAB8A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.949

Property	Details
Experiments	26496610, 28514442, 33961781, 35271311, 26824392, 29125462
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	GDI~Ras
Common GO terms	GO:0005829 - cytosol GO:0030496 - midbody GO:0031267 - small GTPase binding GO:0043025 - neuronal cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 447 Hs			1 207
+	Hs
		678340 GDIA_HUMAN (1-447): 0: 724: 100.00		RAB10_HUMAN (3-181): 4.07e-93: 272: 75.98
+	Hs
		678333 GDIA_HUMAN (1-447): 0: 724: 100.00		RAB13_HUMAN (1-206): 3.19e-89: 262: 61.17
+	Hs
		678359 GDIA_HUMAN (1-447): 0: 724: 100.00		RB11B_HUMAN (4-204): 1.1e-88: 261: 41.63
+	Hs
		678344 GDIA_HUMAN (1-447): 0: 724: 100.00		RAB1A_HUMAN (1-204): 1.23e-87: 258: 54.41
+	Hs
		678394 GDIA_HUMAN (1-447): 0: 724: 100.00		RAB1B_HUMAN (1-204): 7.39e-87: 256: 51.96
+	Mm
		838709 GDIA_MOUSE (1-447): 0: 722: 97.99		RAB1A_MOUSE (1-204): 1.23e-87: 258: 54.41
+	Hs
		678381 GDIA_HUMAN (1-447): 0: 724: 100.00		RAB8B_HUMAN (1-207): 6.41e-86: 253: 82.61
+	Hs
		838619 GDIB_HUMAN (1-444): 0: 700: 86.49		RAB10_HUMAN (3-181): 4.07e-93: 272: 75.98
+	Hs
		678343 GDIA_HUMAN (1-447): 0: 724: 100.00		RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06
+	Hs
		838608 GDIB_HUMAN (1-444): 0: 700: 86.49		RAB13_HUMAN (1-206): 3.19e-89: 262: 61.17
+	Hs
		838647 GDIB_HUMAN (1-444): 0: 700: 86.49		RB11B_HUMAN (4-204): 1.1e-88: 261: 41.63
+	Hs
		838625 GDIB_HUMAN (1-444): 0: 700: 86.49		RAB1A_HUMAN (1-204): 1.23e-87: 258: 54.41
+	Hs
		838683 GDIB_HUMAN (1-444): 0: 700: 86.49		RAB1B_HUMAN (1-204): 7.39e-87: 256: 51.96
+	Hs
		838616 GDIB_HUMAN (1-444): 0: 700: 86.49		RAB8A_HUMAN (1-207): 1.67e-86: 255: 100.00
+	Hs
		838673 GDIB_HUMAN (1-444): 0: 700: 86.49		RAB8B_HUMAN (1-207): 6.41e-86: 253: 82.61
+	Hs
		838624 GDIB_HUMAN (1-444): 0: 700: 86.49		RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06
+	Dm
		183444 Q9VLB7_DROME (1-440): 0: 657: 67.80		O15971_DROME (3-204): 1.35e-92: 271: 68.81
+	Dm
		185501 Q9VLB7_DROME (1-440): 0: 657: 67.80		O18332_DROME (2-203): 2.17e-82: 245: 50.99
+	Sc
		350882 GDI1_YEAST (1-429): 0: 590: 55.05		YPT1_YEAST (1-204): 6.16e-81: 241: 49.03
+	Sc
		350859 RAEP_YEAST (2-374): 4.73e-121: 367: 26.13		YPT1_YEAST (1-204): 6.16e-81: 241: 49.03