HitPredict

Interactor 1: PSA1 (P25786)
Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6)
Gene: PSMA1

Interactor 2: PSMF1 (Q92530)
Proteasome inhibitor PI31 subunit (hPI31)
Gene: PSMF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PI31_Prot_C~Proteasome
Common GO terms	GO:0005829 - cytosol GO:0005839 - proteasome core complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 263 Hs			1 271
+	Hs
		165385 PSA7_HUMAN (6-234): 5.38e-96: 283: 33.19		PSMF1_HUMAN (1-271): 3.21e-157: 439: 100.00
+	Hs
		700697 PSA5_HUMAN (1-236): 4.19e-93: 275: 28.81		PSMF1_HUMAN (1-271): 3.21e-157: 439: 100.00
+	Hs
		954868 PSA6_HUMAN (1-240): 7.5e-93: 275: 25.00		PSMF1_HUMAN (1-271): 3.21e-157: 439: 100.00
+	Hs
		681692 PSA4_HUMAN (1-233): 2.18e-91: 272: 28.75		PSMF1_HUMAN (1-271): 3.21e-157: 439: 100.00
+	Dm
		556731 PSA1_DROME (1-260): 3.17e-99: 292: 52.42		PSMF1_DROME (3-270): 5.02e-108: 315: 29.46
+	Hs
		954826 PSA6_HUMAN (1-240): 7.5e-93: 275: 25.00		Q5QPM9_HUMAN (1-183): 1.98e-104: 302: 100.00
+	Dm
		652771 PSA71_DROME (4-233): 2.41e-38: 136: 33.48		PSMF1_DROME (3-270): 5.02e-108: 315: 29.46