Protein: PSMF1
Proteasome inhibitor PI31 subunit (hPI31)

Gene: PSMF1
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q92530

Gene Ontology (top 5):
GO:0004866 - endopeptidase inhibitor activity
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0005839 - proteasome core complex
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1363770

FBX7
F-box only protein 7

11

1

Small-scale

0.982

High

1363752

PSB7
Proteasome subunit beta type-7

4

3

High-throughput

0.892

High

633756

PSB1
Proteasome subunit beta type-1

3

8

High-throughput

0.871

High

165385

PSA7
Proteasome subunit alpha type-7

3

6

High-throughput

0.863

High

680969

PSA1
Proteasome subunit alpha type-1

3

7

High-throughput

0.861

High

681206

PSA2
Proteasome subunit alpha type-2

3

6

Small-scale

0.861

High

700533

PSB9
Proteasome subunit beta type-9

3

5

High-throughput

0.861

High

700934

PSB4
Proteasome subunit beta type-4

3

7

High-throughput

0.861

High

700697

PSA5
Proteasome subunit alpha type-5

3

5

High-throughput

0.855

High

887573

PSB3
Proteasome subunit beta type-3

2

4

High-throughput

0.811

High

887706

PSB2
Proteasome subunit beta type-2

2

4

High-throughput

0.811

High

681692

PSA4
Proteasome subunit alpha type-4

2

8

High-throughput

0.789

High

1363746

PSMG2
Proteasome assembly chaperone 2

4

0

High-throughput

0.661

High

954868

PSA6
Proteasome subunit alpha type-6

1

7

High-throughput

0.618

High

1348396

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.606

High

488254

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.602

High

992281

SKP1
S-phase kinase-associated protein 1

2

0

High-throughput

0.602

High

1363762

PAK5
Serine/threonine-protein kinase PAK 5

2

0

High-throughput

0.593

High

211378

RFOX2
RNA binding protein fox-1 homolog 2

2

1

High-throughput

0.590

High

1335995

SMIP6
Sperm microtubule inner protein 6

2

0

High-throughput

0.585

High

114606

H0YKT8
Proteasome subunit beta

1

8

High-throughput

0.575

High

1363742

PSMF1
Proteasome inhibitor PI31 subunit

1

1

Small-scale

0.575

High

159772

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.560

High

1363773

MAGD1
Melanoma-associated antigen D1

1

1

High-throughput

0.560

High

284704

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

2

2

High-throughput

0.559

High

1363744

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

2

High-throughput

0.541

High

1363751

QKI
KH domain-containing RNA-binding protein QKI

1

2

High-throughput

0.541

High

132192

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.536

High

1363745

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.536

High

1363768

IKZF3
Zinc finger protein Aiolos

1

0

High-throughput

0.536

High

162850

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

2

High-throughput

0.536

High

851382

PRS6B
26S proteasome regulatory subunit 6B

1

1

High-throughput

0.536

High

968769

PRS4
26S proteasome regulatory subunit 4

1

1

High-throughput

0.536

High

1363761

RFOX1
RNA binding protein fox-1 homolog 1

1

1

High-throughput

0.532

High

335887

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

Small-scale

0.529

High

931031

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.515

High

1289115

TRI74
Tripartite motif-containing protein 74

1

1

High-throughput

0.515

High

211006

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.513

High

337483

PSMG1
Proteasome assembly chaperone 1

1

0

High-throughput

0.513

High

933698

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.513

High

1112630

CUL1
Cullin-1

1

0

High-throughput

0.513

High

1136563

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.513

High

1337513

DDHD1
Phospholipase DDHD1

1

0

High-throughput

0.513

High

1363755

PSMG3
Proteasome assembly chaperone 3

1

0

High-throughput

0.513

High

1363772

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

High-throughput

0.513

High

1219128

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

2

High-throughput

0.512

High

1325742

LNX2
Ligand of Numb protein X 2

1

1

High-throughput

0.512

High

1363767

SHPK
Sedoheptulokinase

1

0

High-throughput

0.493

High

1150458

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

1

High-throughput

0.489

High

848913

MAGAB
Melanoma-associated antigen 11

1

1

High-throughput

0.481

High

1289128

TRI73
Tripartite motif-containing protein 73

1

1

High-throughput

0.481

High

242450

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

537615

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

610422

PRS6A
26S proteasome regulatory subunit 6A

1

4

High-throughput

0.479

High

1363753

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.479

High

1363771

ARI1
E3 ubiquitin-protein ligase ARIH1

1

1

High-throughput

0.479

High

228331

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.460

High

794559

RBMX
RNA-binding motif protein, X chromosome

1

0

High-throughput

0.460

High

1090827

TRAF2
TNF receptor-associated factor 2

1

0

High-throughput

0.460

High

1363749

HOOK2
Protein Hook homolog 2

1

0

High-throughput

0.460

High

1363756

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.460

High

1363760

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.460

High

175141

SC16A
Protein transport protein Sec16A

1

0

Small-scale

0.458

High

831144

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

884376

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

934924

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

954722

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.458

High

1363758

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1363763

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1363764

TBK1
Serine/threonine-protein kinase TBK1

1

0

Small-scale

0.458

High

1363765

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

941505

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.439

High

1103293

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.437

High

1363750

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

1363759

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

708

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.407

High

97082

E9PMD8
Proteasome 26S subunit, ATPase 3

1

4

High-throughput

0.407

High

416031

CP1A1
Cytochrome P450 1A1

3

0

High-throughput

0.347

High

1037299

H11
Histone H1.1

3

0

High-throughput

0.347

High

1330666

BEND7
BEN domain-containing protein 7

2

0

High-throughput

0.326

High

343784

LDOC1
Protein LDOC1

2

0

High-throughput

0.323

High

1363754

RHXF2
Rhox homeobox family member 2

2

0

High-throughput

0.319

High

1120115

RB33A
Ras-related protein Rab-33A

2

0

High-throughput

0.316

High

1363747

TET5B
Terminal nucleotidyltransferase 5B

2

0

High-throughput

0.316

High

210067

CRX
Cone-rod homeobox protein

1

0

High-throughput

0.292

High

590466

GATA1
Erythroid transcription factor

1

0

High-throughput

0.292

High

1061795

TLE5
TLE family member 5

1

0

High-throughput

0.292

High

1286210

RALYL
RNA-binding Raly-like protein

1

0

High-throughput

0.282

High

604779

HXB8
Homeobox protein Hox-B8

1

0

High-throughput

0.279

Low

1012224

RT11
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.279

Low

1014171

CBX1
Chromobox protein homolog 1

1

0

High-throughput

0.279

Low

1358166

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.279

Low

1363766

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

0

High-throughput

0.279

Low

1363769

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

1081552

Q0VDC6
peptidylprolyl isomerase

1

0

High-throughput

0.268

Low

1154554

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.251

Low

1363748

MID49
Mitochondrial dynamics protein MID49

1

0

High-throughput

0.251

Low

696071

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

1254857

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1363743

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

1363757

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025