HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: TCL1A (P56279)
T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)
Gene: TCL1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.758

Property	Details
Experiments	25416956, 25910212, 27229929, 26871637, 10983986, 29997244, 11707444, 12009899, 10716693, 31515488
Identification Methods	two hybrid, affinity chromatography technology, fluorescent resonance energy transfer, pull down, anti tag coimmunoprecipitation, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0033138 - positive regulation of peptidyl-serine phosphorylation GO:0035556 - intracellular signal transduction
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 114
+	Hs
		69535 B0LPE5_HUMAN (1-480): 0: 586: 100.00		TCL1A_HUMAN (1-114): 4.3e-55: 168: 100.00
+	Hs
		681758 AKT1_HUMAN (1-480): 0: 586: 100.00		MTCP1_HUMAN (8-114): 3.17e-49: 153: 40.19
+	Hs
		329026 AKT1_HUMAN (1-480): 0: 586: 100.00		TCL1B_HUMAN (11-113): 4.14e-45: 144: 28.21
+	Hs
		682156 AKT2_HUMAN (1-477): 0: 559: 81.21		TCL1A_HUMAN (1-114): 4.3e-55: 168: 100.00
+	Hs
		880333 AKT3_HUMAN (1-478): 0: 556: 82.50		TCL1A_HUMAN (1-114): 4.3e-55: 168: 100.00
+	Hs
		682155 AKT2_HUMAN (1-477): 0: 559: 81.21		MTCP1_HUMAN (8-114): 3.17e-49: 153: 40.19
+	Hs
		329027 AKT2_HUMAN (1-477): 0: 559: 81.21		TCL1B_HUMAN (11-113): 4.14e-45: 144: 28.21