Protein: LIMK1
LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1)

Gene: LIMK1
Organism: Homo sapiens
Interactions: 94
UniProt ID: P53667

Gene Ontology (top 5):
GO:0001673 - male germ cell nucleus
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

660004

COF1
Cofilin-1

12

4

Small-scale

0.977

High

922238

LIMK2
LIM domain kinase 2

4

18

Small-scale

0.886

High

922237

LIMK1
LIM domain kinase 1

2

17

Small-scale

0.799

High

922240

HUNK
Hormonally up-regulated neu tumor-associated kinase

2

16

Small-scale

0.793

High

922242

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.783

High

922248

PAK1
Serine/threonine-protein kinase PAK 1

1

20

Small-scale

0.770

High

922252

BMPR2
Bone morphogenetic protein receptor type-2

1

20

Small-scale

0.713

High

879702

MAPK2
MAP kinase-activated protein kinase 2

1

20

Small-scale

0.710

High

922249

PAK2
Serine/threonine-protein kinase PAK 2

1

20

Small-scale

0.710

High

922254

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.710

High

922278

SRPK1
SRSF protein kinase 1

1

20

High-throughput

0.710

High

249111

DSCAM
Cell adhesion molecule DSCAM

1

8

High-throughput

0.698

High

354611

PAK4
Serine/threonine-protein kinase PAK 4

1

20

Small-scale

0.692

High

922290

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

20

High-throughput

0.692

High

51591

SPD2B
SH3 and PX domain-containing protein 2B

1

20

High-throughput

0.691

High

440456

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.691

High

520682

RRAS
Ras-related protein R-Ras

1

20

High-throughput

0.691

High

578428

BRAF
Serine/threonine-protein kinase B-raf

1

16

High-throughput

0.691

High

922255

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.691

High

922277

ERBIN
Erbin

1

20

High-throughput

0.691

High

922284

OSBL5
Oxysterol-binding protein-related protein 5

1

7

High-throughput

0.691

High

349013

LATS1
Serine/threonine-protein kinase LATS1

1

20

Small-scale

0.690

High

922286

PAK6
Serine/threonine-protein kinase PAK 6

1

20

Small-scale

0.647

High

853948

KI67
Proliferation marker protein Ki-67

2

7

High-throughput

0.628

High

922268

RXFP2
Relaxin receptor 2

1

20

High-throughput

0.618

High

461302

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468211

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

730463

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

922241

1433E
14-3-3 protein epsilon

1

12

High-throughput

0.618

High

922264

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

922269

SSH1
Protein phosphatase Slingshot homolog 1

1

18

Small-scale

0.604

High

605606

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

19

Small-scale

0.575

High

922258

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.575

High

922259

HS905
Putative heat shock protein HSP 90-alpha A5

1

20

High-throughput

0.575

High

922246

NRG1
Pro-neuregulin-1, membrane-bound isoform

1

8

Small-scale

0.573

High

732492

ARRB2
Beta-arrestin-2

1

6

Small-scale

0.561

High

882419

ARRB1
Beta-arrestin-1

1

6

Small-scale

0.561

High

892747

CDN1C
Cyclin-dependent kinase inhibitor 1C

1

3

Small-scale

0.552

High

50526

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.536

High

65300

RFOX3
RNA binding protein fox-1 homolog 3

1

8

High-throughput

0.536

High

552541

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

3

High-throughput

0.536

High

635304

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

3

High-throughput

0.536

High

644483

PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

1

1

High-throughput

0.536

High

697480

PYR1
Multifunctional protein CAD

1

7

High-throughput

0.536

High

722919

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.536

High

899651

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

4

High-throughput

0.536

High

915932

NUP98
Nuclear pore complex protein Nup98-Nup96

1

6

High-throughput

0.536

High

922239

ITA1
Integrin alpha-1

1

9

High-throughput

0.536

High

922244

BORG5
Cdc42 effector protein 1

1

3

High-throughput

0.536

High

922253

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

10

High-throughput

0.536

High

922257

AGK
Acylglycerol kinase, mitochondrial

1

2

High-throughput

0.536

High

922265

SEP14
Septin-14

1

14

High-throughput

0.536

High

922266

LONP2
Lon protease homolog 2, peroxisomal

1

9

High-throughput

0.536

High

922271

RAD54
DNA repair and recombination protein RAD54-like

1

9

High-throughput

0.536

High

922272

HDAC2
Histone deacetylase 2

1

6

High-throughput

0.536

High

922273

BAD
Bcl2-associated agonist of cell death

1

3

High-throughput

0.536

High

922275

S35E1
Solute carrier family 35 member E1

1

2

High-throughput

0.536

High

922276

RBM14
RNA-binding protein 14

1

13

High-throughput

0.536

High

922279

MMS19
MMS19 nucleotide excision repair protein homolog

1

4

High-throughput

0.536

High

922280

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

4

High-throughput

0.536

High

922281

LGMN
Legumain

1

1

High-throughput

0.536

High

922282

METH
Methionine synthase

1

1

High-throughput

0.536

High

922287

RTEL1
Regulator of telomere elongation helicase 1

1

1

High-throughput

0.536

High

922291

LAS1L
Ribosomal biogenesis protein LAS1L

1

1

High-throughput

0.536

High

192799

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.513

High

284813

TADA3
Transcriptional adapter 3

1

0

High-throughput

0.513

High

922243

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.513

High

922251

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.513

High

922283

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.513

High

922288

UXT
Protein UXT

1

0

High-throughput

0.513

High

388054

MBP
Myelin basic protein

1

2

Small-scale

0.501

High

421772

A4
Amyloid-beta precursor protein

1

11

High-throughput

0.501

High

922247

H11
Histone H1.1

1

5

Small-scale

0.501

High

922289

FBX7
F-box only protein 7

1

7

High-throughput

0.501

High

829322

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

12

High-throughput

0.489

High

922261

MIIP
Migration and invasion-inhibitory protein

1

1

High-throughput

0.489

High

922263

LTOR1
Ragulator complex protein LAMTOR1

1

5

High-throughput

0.489

High

922274

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

2

High-throughput

0.489

High

922285

GHC1
Mitochondrial glutamate carrier 1

1

15

High-throughput

0.489

High

124757

AIP
AH receptor-interacting protein

1

20

High-throughput

0.479

High

241180

PRKN
E3 ubiquitin-protein ligase parkin

1

10

Small-scale

0.479

High

612947

EGR1
Early growth response protein 1

1

5

High-throughput

0.479

High

761600

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.479

High

894404

MMP14
Matrix metalloproteinase-14

1

6

Small-scale

0.479

High

922245

KIF23
Kinesin-like protein KIF23

1

4

Small-scale

0.479

High

922250

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.479

High

922260

DCAF6
DDB1- and CUL4-associated factor 6

1

8

High-throughput

0.479

High

922267

SSH3
Protein phosphatase Slingshot homolog 3

1

17

Small-scale

0.479

High

69365

WASH1
WASH complex subunit 1

1

0

High-throughput

0.460

High

839443

PI4KA
Phosphatidylinositol 4-kinase alpha

1

11

High-throughput

0.445

High

922256

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

11

High-throughput

0.437

High

922270

CV015
Uncharacterized protein C22orf15

3

0

High-throughput

0.346

High

922262

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025