HitPredict

Interactor 1: IL2RG (P31785)
Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
Gene: IL2RG

Interactor 2: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 0.60 0.704

The method score is based on:

Property Details
Experiments 27742835, 7973659, 7973658, 7973657, 10629052
Identification Methods affinity chromatography technology, experimental interaction detection, anti tag coimmunoprecipitation, in-gel kinase assay
Interaction Type physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005768 - endosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0019221 - cytokine-mediated signaling pathway
GO:0035723 - interleukin-15-mediated signaling pathway
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 369
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024