HitPredict

Interactor 1: UBC1 (P25865)
Ubiquitin-conjugating enzyme E2 1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 1) (Ubiquitin carrier protein 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase 1)
Gene: UBC1

Interactor 2: BRE1B (Q9C895)
E3 ubiquitin-protein ligase BRE1-like 2 (EC 2.3.2.27) (Protein HISTONE MONOUBIQUITINATION 2) (AtHUB2) (RING-type E3 ubiquitin transferase BRE1-like 2)
Gene: HUB2

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	18849490
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0010228 - vegetative to reproductive phase transition of meristem GO:0016567 - protein ubiquitination
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 152 At			1 900
+	At
		842111 UBC2_ARATH (1-152): 9.06e-75: 221: 98.68		BRE1B_ARATH (1-900): 2.22e-67: 243: 100.00
+	Hs
		982207 UB2D2_HUMAN (5-150): 2.96e-79: 232: 45.89		BRE1A_HUMAN (46-900): 6.34e-45: 177: 19.03
+	Ce
		759582 UBC2_CAEEL (5-150): 3.31e-79: 232: 44.52		BRE1_CAEEL (45-900): 2.44e-43: 171: 15.73
+	At
		683038 UBC1_ARATH (1-152): 1.17e-74: 221: 100.00		BRE1A_ARATH (55-900): 1.81e-46: 181: 28.66
+	At
		842110 UBC2_ARATH (1-152): 9.06e-75: 221: 98.68		BRE1A_ARATH (55-900): 1.81e-46: 181: 28.66
+	Hs
		884349 UBE2A_HUMAN (1-149): 1.53e-73: 218: 77.18		BRE1A_HUMAN (46-900): 6.34e-45: 177: 19.03
+	Hs
		909325 UB2E1_HUMAN (3-150): 3.19e-72: 216: 37.16		BRE1A_HUMAN (46-900): 6.34e-45: 177: 19.03
+	Hs
		990970 UBE2B_HUMAN (1-149): 8.46e-73: 216: 76.51		BRE1A_HUMAN (46-900): 6.34e-45: 177: 19.03
+	Ce
		759583 UBC1_CAEEL (1-149): 2.83e-72: 216: 73.15		BRE1_CAEEL (45-900): 2.44e-43: 171: 15.73
+	Sc
		438550 UBC2_YEAST (1-149): 2.97e-76: 226: 63.76		BRE1_YEAST (346-900): 8.31e-25: 112: 16.09
+	Sp
		660353 UBC2_SCHPO (1-151): 5.98e-73: 216: 70.86		BRL1_SCHPO (239-895): 1.76e-18: 92.6: 14.35
+	Sp
		267889 UBC2_SCHPO (1-151): 5.98e-73: 216: 70.86		BRL2_SCHPO (457-895): 3.97e-18: 91.5: 16.95
+	Hs
		272638 UB2D2_HUMAN (5-150): 2.96e-79: 232: 45.89		BRE1B_HUMAN (5-722): 2.84e-11: 69.7: 10.59
+	Hs
		272628 UBE2A_HUMAN (1-149): 1.53e-73: 218: 77.18		BRE1B_HUMAN (5-722): 2.84e-11: 69.7: 10.59
+	Hs
		272630 UB2E1_HUMAN (3-150): 3.19e-72: 216: 37.16		BRE1B_HUMAN (5-722): 2.84e-11: 69.7: 10.59
+	Hs
		272640 UBE2B_HUMAN (1-149): 8.46e-73: 216: 76.51		BRE1B_HUMAN (5-722): 2.84e-11: 69.7: 10.59