Protein: BRE1B
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)

Gene: BRE1B, RNF40
Organism: Homo sapiens
Interactions: 215
UniProt ID: O75150

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003730 - mRNA 3'-UTR binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006325 - chromatin organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

272682

BRE1A
E3 ubiquitin-protein ligase BRE1A

20

19

Small-scale

0.987

High

272628

UBE2A
Ubiquitin-conjugating enzyme E2 A

6

16

Small-scale

0.944

High

272584

BRE1B
E3 ubiquitin-protein ligase BRE1B

4

18

Small-scale

0.890

High

272640

UBE2B
Ubiquitin-conjugating enzyme E2 B

4

16

Small-scale

0.888

High

272671

H2B2E
Histone H2B type 2-E

3

20

Small-scale

0.840

High

272641

UBC9
SUMO-conjugating enzyme UBC9

2

19

High-throughput

0.754

High

272742

WAC
WW domain-containing adapter protein with coiled-coil

4

5

Small-scale

0.708

High

272699

Q7KZS0
SUMO-conjugating enzyme UBC9

2

17

High-throughput

0.706

High

272647

NCBP1
Nuclear cap-binding protein subunit 1

4

2

High-throughput

0.700

High

272597

P53
Cellular tumor antigen p53

5

6

Small-scale

0.699

High

272780

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

4

13

Small-scale

0.694

High

272620

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.692

High

272606

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

10

High-throughput

0.691

High

272670

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

14

High-throughput

0.691

High

272758

DISC1
Disrupted in schizophrenia 1 protein

4

6

High-throughput

0.691

High

272607

ANDR
Androgen receptor

4

19

Small-scale

0.676

High

272752

DSN1
Kinetochore-associated protein DSN1 homolog

3

2

High-throughput

0.667

High

272598

H2A1B
Histone H2A type 1-B/E

1

18

Small-scale

0.647

High

272630

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

13

Small-scale

0.647

High

272638

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

13

High-throughput

0.647

High

217025

MS18B
Protein Mis18-beta

3

0

High-throughput

0.638

High

272704

MORC1
MORC family CW-type zinc finger protein 1

3

0

High-throughput

0.638

High

272591

NOE2
Noelin-2

2

2

High-throughput

0.628

High

272652

MED21
Mediator of RNA polymerase II transcription subunit 21

2

1

High-throughput

0.628

High

272716

TCP1L
T-complex protein 10A homolog 1

2

1

High-throughput

0.628

High

272718

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

11

High-throughput

0.628

High

272750

TX13A
Testis-expressed protein 13A

2

1

High-throughput

0.628

High

272770

ZN232
Zinc finger protein 232

2

3

High-throughput

0.628

High

168480

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

14

Small-scale

0.618

High

240261

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.618

High

272696

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

272771

TRI33
E3 ubiquitin-protein ligase TRIM33

1

15

High-throughput

0.618

High

272774

AMOL2
Angiomotin-like protein 2

3

18

High-throughput

0.616

High

272709

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

2

0

High-throughput

0.616

High

272660

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

6

High-throughput

0.611

High

272686

VIR
Protein virilizer homolog

2

6

High-throughput

0.611

High

272590

SNP29
Synaptosomal-associated protein 29

3

1

High-throughput

0.609

High

272767

IL36A
Interleukin-36 alpha

3

1

High-throughput

0.609

High

272685

DUS29
Dual specificity phosphatase 29

2

8

High-throughput

0.606

High

272693

ZCH12
Zinc finger CCHC domain-containing protein 12

2

1

High-throughput

0.606

High

272623

HD
Huntingtin

2

4

High-throughput

0.596

High

272714

SIR6
NAD-dependent protein deacylase sirtuin-6

2

8

Small-scale

0.584

High

272632

KIF11
Kinesin-like protein KIF11

1

5

Small-scale

0.578

High

272695

INSY2
Inhibitory synaptic factor 2A

2

1

High-throughput

0.574

High

272708

SNX32
Sorting nexin-32

2

1

High-throughput

0.574

High

272737

NELL2
Protein kinase C-binding protein NELL2

2

4

High-throughput

0.574

High

272747

NUP58
Nucleoporin p58/p45

2

1

High-throughput

0.574

High

272775

COG6
Conserved oligomeric Golgi complex subunit 6

2

1

High-throughput

0.574

High

272777

WASC3
WASH complex subunit 3

2

1

High-throughput

0.574

High

272617

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

Small-scale

0.561

High

272651

ATM
Serine-protein kinase ATM

1

9

Small-scale

0.561

High

272603

FCG3A
Low affinity immunoglobulin gamma Fc region receptor III-A

2

5

High-throughput

0.558

High

272689

CDC73
Parafibromin

1

4

Small-scale

0.552

High

272600

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.549

High

272634

PKNX1
Homeobox protein PKNOX1

1

4

High-throughput

0.541

High

272741

TRI51
Tripartite motif-containing protein 51

1

8

High-throughput

0.541

High

272779

ZN451
E3 SUMO-protein ligase ZNF451

1

2

High-throughput

0.541

High

272618

EF1D
Elongation factor 1-delta

1

4

Small-scale

0.536

High

156224

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

3

High-throughput

0.536

High

214649

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

8

High-throughput

0.536

High

222402

PLRG1
Pleiotropic regulator 1

1

11

High-throughput

0.536

High

272586

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

12

High-throughput

0.536

High

272605

TFPT
TCF3 fusion partner

1

1

High-throughput

0.536

High

272609

BIP
Endoplasmic reticulum chaperone BiP

1

11

High-throughput

0.536

High

272612

DDX5
Probable ATP-dependent RNA helicase DDX5

1

7

High-throughput

0.536

High

272615

S100P
Protein S100-P

1

20

High-throughput

0.536

High

272621

NUP62
Nuclear pore glycoprotein p62

1

9

High-throughput

0.536

High

272624

MAGA9
Melanoma-associated antigen 9

1

9

High-throughput

0.536

High

272625

NOTC1
Neurogenic locus notch homolog protein 1

1

3

High-throughput

0.536

High

272643

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.536

High

272650

SRSF9
Serine/arginine-rich splicing factor 9

1

14

High-throughput

0.536

High

272655

SAFB2
Scaffold attachment factor B2

1

14

High-throughput

0.536

High

272657

ZN460
Zinc finger protein 460

1

1

High-throughput

0.536

High

272659

FL2D
Pre-mRNA-splicing regulator WTAP

1

1

High-throughput

0.536

High

272662

RNPS1
RNA-binding protein with serine-rich domain 1

1

11

High-throughput

0.536

High

272663

SAFB1
Scaffold attachment factor B1

1

11

High-throughput

0.536

High

272666

PKN1
Serine/threonine-protein kinase N1

1

7

High-throughput

0.536

High

272676

ZN326
DBIRD complex subunit ZNF326

1

2

High-throughput

0.536

High

272678

SNPC4
snRNA-activating protein complex subunit 4

1

1

High-throughput

0.536

High

272679

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

19

High-throughput

0.536

High

272680

SYT6
Synaptotagmin-6

1

3

High-throughput

0.536

High

272681

CE350
Centrosome-associated protein 350

1

19

High-throughput

0.536

High

272690

PRP8
Pre-mRNA-processing-splicing factor 8

1

4

High-throughput

0.536

High

272701

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

4

High-throughput

0.536

High

272703

THOC4
THO complex subunit 4

1

7

High-throughput

0.536

High

272706

ZCH18
Zinc finger CCCH domain-containing protein 18

1

15

High-throughput

0.536

High

272711

RB12B
RNA-binding protein 12B

1

18

High-throughput

0.536

High

272719

CTBL1
Beta-catenin-like protein 1

1

1

High-throughput

0.536

High

272723

MGN2
Protein mago nashi homolog 2

1

2

High-throughput

0.536

High

272725

PF21B
PHD finger protein 21B

1

20

High-throughput

0.536

High

272726

THOC1
THO complex subunit 1

1

2

High-throughput

0.536

High

272731

YTDC1
YTH domain-containing protein 1

1

5

High-throughput

0.536

High

272734

IWS1
Protein IWS1 homolog

1

10

High-throughput

0.536

High

272735

RBM15
RNA-binding protein 15

1

7

High-throughput

0.536

High

272736

MINT
Msx2-interacting protein

1

12

High-throughput

0.536

High

272745

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

14

High-throughput

0.536

High

272756

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.536

High

272761

RBM12
RNA-binding protein 12

1

17

High-throughput

0.536

High

272764

BCLF1
Bcl-2-associated transcription factor 1

1

9

High-throughput

0.536

High

272765

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

9

High-throughput

0.536

High

272769

PRP19
Pre-mRNA-processing factor 19

1

14

High-throughput

0.536

High

272776

TR150
Thyroid hormone receptor-associated protein 3

1

13

High-throughput

0.536

High

272781

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

1

High-throughput

0.536

High

272782

RBM8A
RNA-binding protein 8A

1

8

High-throughput

0.536

High

272712

CC146
Coiled-coil domain-containing protein 146

1

18

High-throughput

0.523

High

272613

PRS6A
26S proteasome regulatory subunit 6A

1

9

High-throughput

0.515

High

272585

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.513

High

272656

FA50A
Protein FAM50A

1

0

High-throughput

0.513

High

272661

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.513

High

272688

THOC7
THO complex subunit 7

1

0

High-throughput

0.513

High

272697

TF2H5
General transcription factor IIH subunit 5

1

0

High-throughput

0.513

High

272732

VMA22
Vacuolar ATPase assembly protein VMA22

1

0

High-throughput

0.513

High

272738

T22D3
TSC22 domain family protein 3

1

0

High-throughput

0.513

High

272749

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

272778

SKAP
Small kinetochore-associated protein

1

0

High-throughput

0.513

High

272668

STX1A
Syntaxin-1A

1

2

Small-scale

0.512

High

272611

RFA2
Replication protein A 32 kDa subunit

1

5

Small-scale

0.501

High

272684

MSL1
Male-specific lethal 1 homolog

1

1

Small-scale

0.501

High

272587

KRT38
Keratin, type I cuticular Ha8

1

16

High-throughput

0.489

High

272604

ITA5
Integrin alpha-5

1

3

High-throughput

0.489

High

272616

G0S2
G0/G1 switch protein 2

1

1

High-throughput

0.489

High

272673

CF184
Cilia- and flagella-associated protein 184

1

1

High-throughput

0.489

High

272674

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

272691

KLC3
Kinesin light chain 3

1

2

High-throughput

0.489

High

272713

SYCE1
Synaptonemal complex central element protein 1

1

1

High-throughput

0.489

High

272717

BRK1
Protein BRICK1

1

2

High-throughput

0.489

High

272733

CC85A
Coiled-coil domain-containing protein 85A

1

1

High-throughput

0.489

High

272739

KXDL1
KxDL motif-containing protein 1

1

2

High-throughput

0.489

High

272746

BBLN
Bublin coiled-coil protein

1

1

High-throughput

0.489

High

272760

KRT82
Keratin, type II cuticular Hb2

1

5

High-throughput

0.489

High

272772

ANGP4
Angiopoietin-4

1

2

High-throughput

0.489

High

272783

WIF1
Wnt inhibitory factor 1

1

4

High-throughput

0.489

High

272629

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

130327

SPT5H
Transcription elongation factor SPT5

1

6

High-throughput

0.479

High

156758

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.479

High

227274

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.479

High

245387

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

3

High-throughput

0.479

High

246331

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

259202

BRD4
Bromodomain-containing protein 4

1

10

High-throughput

0.479

High

262455

MCE1
mRNA-capping enzyme

1

5

High-throughput

0.479

High

272589

PARN
Poly(A)-specific ribonuclease PARN

1

1

High-throughput

0.479

High

272592

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.479

High

272595

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

272596

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.479

High

272599

PERM
Myeloperoxidase

1

2

High-throughput

0.479

High

272601

HS90A
Heat shock protein HSP 90-alpha

1

11

High-throughput

0.479

High

272602

HS90B
Heat shock protein HSP 90-beta

1

11

High-throughput

0.479

High

272619

MARCS
Myristoylated alanine-rich C-kinase substrate

1

6

Small-scale

0.479

High

272622

TALDO
Transaldolase

1

1

High-throughput

0.479

High

272631

NCBP2
Nuclear cap-binding protein subunit 2

1

10

High-throughput

0.479

High

272633

TERF1
Telomeric repeat-binding factor 1

1

4

High-throughput

0.479

High

272636

ISL1
Insulin gene enhancer protein ISL-1

1

5

Small-scale

0.479

High

272637

H4
Histone H4

1

12

High-throughput

0.479

High

272639

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

12

High-throughput

0.479

High

272642

TPM4
Tropomyosin alpha-4 chain

1

13

High-throughput

0.479

High

272644

HSF1
Heat shock factor protein 1

1

5

High-throughput

0.479

High

272645

EWS
RNA-binding protein EWS

1

5

High-throughput

0.479

High

272646

DUSP2
Dual specificity protein phosphatase 2

1

8

Small-scale

0.479

High

272648

EP300
Histone acetyltransferase p300

1

13

High-throughput

0.479

High

272649

FOXC1
Forkhead box protein C1

1

7

High-throughput

0.479

High

272653

HDAC1
Histone deacetylase 1

1

16

High-throughput

0.479

High

272654

CUL4A
Cullin-4A

1

13

Small-scale

0.479

High

272658

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

6

High-throughput

0.479

High

272664

TERF2
Telomeric repeat-binding factor 2

1

4

High-throughput

0.479

High

272667

DDB1
DNA damage-binding protein 1

1

4

Small-scale

0.479

High

272669

IF16
Gamma-interferon-inducible protein 16

1

4

High-throughput

0.479

High

272675

SMU1
WD40 repeat-containing protein SMU1

1

15

Small-scale

0.479

High

272692

FXL19
F-box/LRR-repeat protein 19

1

6

Small-scale

0.479

High

272698

SPT6H
Transcription elongation factor SPT6

1

3

Small-scale

0.479

High

272700

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

272702

ZN598
E3 ubiquitin-protein ligase ZNF598

1

9

High-throughput

0.479

High

272710

MIB1
E3 ubiquitin-protein ligase MIB1

1

3

High-throughput

0.479

High

272720

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.479

High

272724

PF21A
PHD finger protein 21A

1

17

High-throughput

0.479

High

272730

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

272748

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

18

Small-scale

0.479

High

272751

COMD4
COMM domain-containing protein 4

1

1

Small-scale

0.479

High

272757

NLRC4
NLR family CARD domain-containing protein 4

1

9

Small-scale

0.479

High

272763

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

272766

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

272768

RCOR1
REST corepressor 1

1

5

High-throughput

0.479

High

272627

MTR1B
Melatonin receptor type 1B

1

2

High-throughput

0.464

High

272593

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

272594

TRFL
Lactotransferrin

1

0

High-throughput

0.458

High

272694

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

272705

SERC5
Serine incorporator 5

1

0

Small-scale

0.458

High

272721

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

1

0

High-throughput

0.458

High

272722

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

High-throughput

0.458

High

272743

IER2
Immediate early response gene 2 protein

1

0

High-throughput

0.458

High

272755

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

272759

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.458

High

272687

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.457

High

272608

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.445

High

272677

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

272665

ITSN1
Intersectin-1

1

7

High-throughput

0.439

High

272773

NINL
Ninein-like protein

1

18

High-throughput

0.439

High

272744

CENPO
Centromere protein O

1

0

High-throughput

0.438

High

272588

RHBT1
Rho-related BTB domain-containing protein 1

1

20

High-throughput

0.437

High

272610

PDIA4
Protein disulfide-isomerase A4

1

7

High-throughput

0.437

High

272614

PRTN3
Myeloblastin

1

5

High-throughput

0.437

High

272635

WNT4
Protein Wnt-4

1

1

High-throughput

0.437

High

272715

PKHO2
Pleckstrin homology domain-containing family O member 2

1

7

High-throughput

0.437

High

272740

ATGA1
Autophagy-related protein 101

1

2

Small-scale

0.437

High

272754

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

272707

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

272728

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.426

High

272672

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

2

High-throughput

0.407

High

272683

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.407

High

272729

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.279

Low

272762

PDRG1
p53 and DNA damage-regulated protein 1

1

0

High-throughput

0.279

Low

1180

QCR6L
Cytochrome b-c1 complex subunit 6-like, mitochondrial

1

0

High-throughput

0.269

Low

272626

INAR2
Interferon alpha/beta receptor 2

1

0

Small-scale

0.249

Low

272727

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low

272753

TRABD
TraB domain-containing protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025