HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: TSC2 (P49815)
Tuberin (Tuberous sclerosis 2 protein)
Gene: TSC2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	0.60	0.763

Property	Details
Experiments	12582162, 12468542, 12364343, 12176984, 20169078, 33961781, 35271311, 36931259, 16636147, 15324660, 24255178, 17353931, 28514442, 12438239
Identification Methods	affinity chromatography technology, two hybrid, pull down, proximity labelling technology, anti tag coimmunoprecipitation, experimental interaction detection, coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1807
+	Hs
		835035 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		TSC2_HUMAN (1-1807): 0: 2708: 100.00
+	Hs
		835039 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		TSC2_HUMAN (1-1807): 0: 2708: 100.00
+	Hs
		909678 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74
+	Hs
		683443 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74
+	Hs
		196427 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83
+	Hs
		196405 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83
+	Hs
		196429 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83
+	Dm
		114606 1433E_DROME (3-245): 4.63e-144: 405: 64.90		M9PD17_DROME (1255-1756): 5.21e-86: 315: 31.22
+	Dm
		955043 1433E_DROME (3-245): 4.63e-144: 405: 64.90		Q9VW83_DROME (1255-1756): 5.71e-86: 315: 31.22
+	Mm
		926787 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		Q3TQ10_MOUSE (1576-1807): 8.09e-98: 316: 77.69
+	Hs
		910116 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SI1L2_HUMAN (1459-1800): 2.08e-79: 293: 20.17
+	Hs
		683781 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SI1L2_HUMAN (1459-1800): 2.08e-79: 293: 20.17
+	Hs
		230231 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33
+	Hs
		230208 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33
+	Hs
		230235 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33
+	Hs
		683617 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SIPA1_HUMAN (1258-1800): 6.13e-74: 271: 18.39
+	Hs
		812874 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RPGP1_HUMAN (1513-1765): 1.64e-69: 250: 24.23
+	Hs
		683195 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		RPGP1_HUMAN (1513-1765): 1.64e-69: 250: 24.23
+	Hs
		812876 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		RPGP1_HUMAN (1513-1765): 1.64e-69: 250: 24.23
+	Hs
		909669 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RPGP2_HUMAN (1471-1758): 2.83e-66: 242: 22.03