HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: SIK3 (Q9Y2K2)
Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)
Gene: SIK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.671

Property	Details
Experiments	35271311, 36931259, 22588126
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1321
+	Hs
		910187 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SIK3_HUMAN (1-1321): 0: 1267: 100.00
+	Mm
		910231 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK3_MOUSE (1-694): 2.82e-154: 485: 32.11
+	Hs
		647862 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK3_HUMAN (1-694): 4.86e-154: 484: 30.98
+	Hs
		647835 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		MARK3_HUMAN (1-694): 4.86e-154: 484: 30.98
+	Hs
		910013 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SIK2_HUMAN (50-831): 1.65e-151: 483: 34.99
+	Mm
		910308 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK4_MOUSE (1-716): 7.87e-145: 460: 30.89
+	Hs
		909730 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK2_HUMAN (15-704): 3.17e-143: 457: 30.38
+	Hs
		909916 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK4_HUMAN (1-716): 1.15e-143: 457: 30.76
+	Mm
		910234 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK2_MOUSE (15-704): 7.86e-143: 455: 30.37
+	Dm
		90534 1433E_DROME (3-245): 4.63e-144: 405: 64.90		E1JGN0_DROME (9-627): 5.62e-138: 453: 34.25
+	Hs
		883214 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SIK1_HUMAN (50-805): 2.9e-138: 443: 31.73
+	Hs
		910071 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SNRK_HUMAN (52-427): 1.48e-137: 441: 38.85
+	Hs
		871354 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AAPK2_HUMAN (52-589): 2.46e-139: 438: 30.39
+	Hs
		683222 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		AAPK2_HUMAN (52-589): 2.46e-139: 438: 30.39
+	Hs
		909507 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AAPK1_HUMAN (44-598): 1.69e-138: 436: 28.91
+	Rn
		871214 1433E_RAT (3-243): 4.39e-144: 405: 65.43		AAPK1_RAT (44-599): 4.74e-138: 435: 28.98
+	Mm
		910318 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK1_MOUSE (35-488): 1.17e-133: 431: 44.35
+	Hs
		910106 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK1_HUMAN (41-382): 1.92e-105: 354: 55.43
+	Hs
		909786 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		BRSK2_HUMAN (63-398): 9.43e-78: 275: 43.49
+	Mm
		910272 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		BRSK2_MOUSE (63-398): 5.78e-78: 275: 43.49