HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: TSC2 (P49815)
Tuberin (Tuberous sclerosis 2 protein)
Gene: TSC2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	36931259, 12438239
Identification Methods	proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006469 - negative regulation of protein kinase activity GO:0051726 - regulation of cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 1807
+	Hs
		835035 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		TSC2_HUMAN (1-1807): 0: 2708: 100.00
+	Hs
		835039 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		TSC2_HUMAN (1-1807): 0: 2708: 100.00
+	Hs
		684116 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74
+	Hs
		909678 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74
+	Hs
		196406 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83
+	Hs
		196427 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83
+	Hs
		684372 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SI1L2_HUMAN (1459-1800): 2.08e-79: 293: 20.17
+	Hs
		230209 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33
+	Dm
		114606 1433E_DROME (2-247): 2.8e-144: 405: 58.07		M9PD17_DROME (1255-1756): 5.21e-86: 315: 31.22
+	Dm
		955043 1433E_DROME (2-247): 2.8e-144: 405: 58.07		Q9VW83_DROME (1255-1756): 5.71e-86: 315: 31.22
+	Hs
		196429 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83
+	Hs
		910116 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SI1L2_HUMAN (1459-1800): 2.08e-79: 293: 20.17
+	Mm
		926787 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		Q3TQ10_MOUSE (1576-1807): 8.09e-98: 316: 77.69
+	Hs
		230231 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33
+	Hs
		683896 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		RPGP1_HUMAN (1513-1765): 1.64e-69: 250: 24.23
+	Hs
		230235 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33
+	Hs
		812874 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		RPGP1_HUMAN (1513-1765): 1.64e-69: 250: 24.23
+	Hs
		909669 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		RPGP2_HUMAN (1471-1758): 2.83e-66: 242: 22.03
+	Hs
		812876 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		RPGP1_HUMAN (1513-1765): 1.64e-69: 250: 24.23
+	Hs
		927156 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		RPGP2_HUMAN (1471-1758): 2.83e-66: 242: 22.03