Protein: INSR
Insulin-like receptor (dIR) (dInr) (dmIR) (EC 2.7.10.1) (Insulin receptor homolog) (dIRH) (Receptor protein-tyrosine kinase InR) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1 (Insulin-like receptor subunit beta 170 kDa form) (beta170); Insulin-like receptor subunit beta 2 (Insulin-like receptor subunit beta 90 kDa form) (beta90); 60 kDa C-terminal fragment (Insulin-like receptor free C-terminus)]

Gene: INSR, InR
Organism: Drosophila melanogaster
Interactions: 47
UniProt ID: P09208

Gene Ontology (top 5):
GO:0001700 - embryonic development via the syncytial blastoderm
GO:0002052 - positive regulation of neuroblast proliferation
GO:0004713 - protein tyrosine kinase activity
GO:0005009 - insulin receptor activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

119556

M9PAY7
Pi3K21B, isoform C

3

20

High-throughput

0.827

High

479707

LAR
Tyrosine-protein phosphatase Lar

2

20

Small-scale

0.789

High

391867

HSP83
Heat shock protein 83

2

20

Small-scale

0.757

High

479706

INSR
Insulin-like receptor

2

17

Small-scale

0.755

High

479740

IRS1
Insulin receptor substrate 1

8

16

Small-scale

0.746

High

479711

MOEH
Moesin/ezrin/radixin homolog 1

1

20

High-throughput

0.698

High

479709

PTP99
Tyrosine-protein phosphatase 99A

1

20

Small-scale

0.692

High

479720

Q7K137
LD10453p

1

20

Small-scale

0.647

High

479722

INSL5
Insulin-like peptide 5

1

1

Small-scale

0.647

High

479717

CDC37
Hsp90 co-chaperone Cdc37

1

20

Small-scale

0.621

High

479708

1433Z
14-3-3 protein zeta

1

20

High-throughput

0.618

High

479730

Q9VAY2
Heat shock protein 83

1

20

High-throughput

0.618

High

479731

FLNA
Filamin-A

1

12

High-throughput

0.618

High

479738

PTP61
Tyrosine-protein phosphatase non-receptor type 61F

1

20

Small-scale

0.618

High

479713

P91634
phosphatidylinositol 3-kinase

2

20

High-throughput

0.584

High

198225

O18683
LD42724p

1

20

High-throughput

0.575

High

479716

DYL1
Dynein light chain 1, cytoplasmic

2

0

High-throughput

0.559

High

479718

SEM1A
Semaphorin-1A

1

14

High-throughput

0.536

High

196063

RL15
Large ribosomal subunit protein eL15

2

1

High-throughput

0.533

High

118759

M9NFI9
Neurabin-1

1

20

High-throughput

0.514

High

479741

Q9XYW6
E3 ubiquitin-protein ligase CHIP

1

19

Small-scale

0.512

High

479723

NCK
SH2/SH3 adapter protein dreadlocks

1

20

High-throughput

0.492

High

462176

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

14

High-throughput

0.479

High

479721

Q7K1R6
LD46221p

1

7

High-throughput

0.479

High

479732

Q9VFV9
DnaJ-like-2, isoform A

1

20

High-throughput

0.479

High

479737

Q9VV75
AT02348p

1

3

High-throughput

0.479

High

479719

Q4V5V6
GEO10744p1

1

0

Small-scale

0.458

High

479715

Q0E8S4
Semaphorin-1A

1

15

High-throughput

0.445

High

94900

E1JGL8
Uncharacterized protein, isoform C

1

7

High-throughput

0.437

High

262616

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.437

High

479710

RSSA
Small ribosomal subunit protein uS2

1

3

High-throughput

0.437

High

479714

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

479724

RS23
Small ribosomal subunit protein uS12

1

1

High-throughput

0.437

High

479725

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

3

High-throughput

0.437

High

479727

Q9V3W7
LD40489p

1

12

High-throughput

0.437

High

479728

Q9V9W2
Large ribosomal subunit protein eL6

1

3

High-throughput

0.437

High

479729

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.437

High

479734

Q9VGH5
AT27789p

1

20

High-throughput

0.437

High

479739

RS28
Small ribosomal subunit protein eS28

1

1

High-throughput

0.437

High

52607

A1Z720
Uncharacterized protein, isoform A

1

0

High-throughput

0.249

Low

471468

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.249

Low

479712

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.249

Low

479726

Q95RF6
LD34461p

1

0

High-throughput

0.249

Low

479733

ELP6
Elongator complex protein 6

1

0

Small-scale

0.249

Low

479735

Q9VJ19
Large ribosomal subunit protein eL30

1

0

High-throughput

0.249

Low

479736

ZUC
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025