HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 603
+	Hs
		861687 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		684360 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		PLK2_HUMAN (38-587): 7.26e-163: 482: 36.69
+	Hs
		910097 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		PLK2_HUMAN (38-587): 7.26e-163: 482: 36.69
+	At
		965291 14332_ARATH (3-248): 2.23e-144: 405: 58.47		CDPK1_ARATH (1-498): 7.83e-155: 459: 22.09
+	At
		802001 14334_ARATH (3-248): 1.23e-142: 401: 56.45		CDPK1_ARATH (1-498): 7.83e-155: 459: 22.09
+	At
		788694 14335_ARATH (2-247): 4.54e-140: 395: 56.05		CDPK1_ARATH (1-498): 7.83e-155: 459: 22.09
+	At
		1280891 14337_ARATH (2-247): 4.35e-147: 413: 58.07		CIPKC_ARATH (25-356): 2.96e-134: 402: 27.76
+	At
		788672 14333_ARATH (3-247): 2.63e-144: 405: 58.30		CIPKC_ARATH (25-356): 2.96e-134: 402: 27.76
+	At
		965360 14332_ARATH (3-248): 2.23e-144: 405: 58.47		CIPKC_ARATH (25-356): 2.96e-134: 402: 27.76
+	Hs
		684052 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43
+	Hs
		909590 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43
+	Hs
		647354 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		KS6B2_HUMAN (53-412): 9.32e-134: 401: 24.66
+	Hs
		646913 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Hs
		128972 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		PLK4_HUMAN (56-306): 2.18e-55: 204: 37.70
+	Hs
		646741 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		KS6A3_HUMAN (1-326): 1.91e-103: 331: 25.44
+	Hs
		128986 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		PLK4_HUMAN (56-306): 2.18e-55: 204: 37.70
+	Hs
		128988 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		PLK4_HUMAN (56-306): 2.18e-55: 204: 37.70
+	Hs
		909991 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		STK33_HUMAN (53-333): 8.74e-44: 165: 33.45
+	Hs
		128970 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		PLK4_HUMAN (56-306): 2.18e-55: 204: 37.70
+	Hs
		128971 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		PLK4_HUMAN (56-306): 2.18e-55: 204: 37.70