Protein: MYLIP
E3 ubiquitin-protein ligase MYLIP (EC 2.3.2.27) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR) (RING-type E3 ubiquitin transferase MYLIP)

Gene: MYLIP
Organism: Homo sapiens
Interactions: 62
UniProt ID: Q8WY64

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1361422

MYLIP
E3 ubiquitin-protein ligase MYLIP

4

15

Small-scale

0.913

High

906722

UB2D1
Ubiquitin-conjugating enzyme E2 D1

3

4

Small-scale

0.876

High

957148

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

4

Small-scale

0.778

High

982263

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

4

Small-scale

0.778

High

376531

LDLR
Low-density lipoprotein receptor

5

3

Small-scale

0.713

High

1325741

LNX2
Ligand of Numb protein X 2

3

16

High-throughput

0.658

High

957803

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

4

Small-scale

0.647

High

1361437

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

4

Small-scale

0.647

High

287981

MYCB2
E3 ubiquitin-protein ligase MYCBP2

2

1

High-throughput

0.628

High

1309832

WDFY1
WD repeat and FYVE domain-containing protein 1

2

6

High-throughput

0.628

High

74356

ZBT42
Zinc finger and BTB domain-containing protein 42

2

3

High-throughput

0.606

High

140385

SDCB1
Syntenin-1

2

10

High-throughput

0.606

High

1214240

KANK4
KN motif and ankyrin repeat domain-containing protein 4

2

17

High-throughput

0.606

High

1347691

ZN417
Zinc finger protein 417

2

1

High-throughput

0.606

High

1361426

HOOK2
Protein Hook homolog 2

2

16

High-throughput

0.606

High

1361428

ZBT18
Zinc finger and BTB domain-containing protein 18

2

3

High-throughput

0.606

High

1359823

RASF5
Ras association domain-containing protein 5

2

0

High-throughput

0.601

High

855704

CRK
Adapter molecule crk

2

12

High-throughput

0.594

High

1361435

DAPP1
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

2

20

High-throughput

0.594

High

1051401

ZBT16
Zinc finger and BTB domain-containing protein 16

2

0

High-throughput

0.580

High

1278722

ZN438
Zinc finger protein 438

2

0

High-throughput

0.580

High

1288878

NOXA1
NADPH oxidase activator 1

2

0

High-throughput

0.580

High

1361429

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.580

High

1361430

IN80B
INO80 complex subunit B

2

0

High-throughput

0.580

High

1361431

EXOS5
Exosome complex component RRP46

2

0

High-throughput

0.580

High

1361433

F217B
Protein FAM217B

2

0

High-throughput

0.580

High

1330546

PAF1
RNA polymerase II-associated factor 1 homolog

2

1

High-throughput

0.574

High

1022523

VLDLR
Very low-density lipoprotein receptor

2

3

Small-scale

0.563

High

520229

ANDR
Androgen receptor

1

16

Small-scale

0.561

High

1292915

Q86WV8
TSC complex subunit 1

2

7

High-throughput

0.558

High

938485

PAX9
Paired box protein Pax-9

2

1

High-throughput

0.553

High

1044689

ARI5A
AT-rich interactive domain-containing protein 5A

2

1

High-throughput

0.553

High

1250271

ATL4
ADAMTS-like protein 4

2

1

High-throughput

0.553

High

1361427

GMCL1
Germ cell-less protein-like 1

2

2

High-throughput

0.553

High

169125

ML12B
Myosin regulatory light chain 12B

1

1

Small-scale

0.552

High

48373

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

1

High-throughput

0.536

High

1361438

T22D4
TSC22 domain family protein 4

1

5

High-throughput

0.523

High

1237995

Q6NSM0
NR1D2 protein

1

16

High-throughput

0.515

High

1279671

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

1361434

ICAM5
Intercellular adhesion molecule 5

1

20

High-throughput

0.515

High

1006595

SRPK2
SRSF protein kinase 2

1

17

High-throughput

0.501

High

167341

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

216765

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.493

High

927079

ATX3
Ataxin-3

1

0

High-throughput

0.493

High

1134833

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

10

High-throughput

0.481

High

1361423

TSC1
Hamartin

1

20

High-throughput

0.481

High

109480

G5E9A7
DM1 locus, WD repeat containing

1

2

High-throughput

0.470

High

1361424

APBB2
Amyloid beta precursor protein binding family B member 2

1

1

High-throughput

0.470

High

246814

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.464

High

613114

EGR1
Early growth response protein 1

1

0

Small-scale

0.458

High

1361432

BMP2K
BMP-2-inducible protein kinase

1

15

Small-scale

0.451

High

288477

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

2

Small-scale

0.437

High

1120574

LRP8
Low-density lipoprotein receptor-related protein 8

1

3

Small-scale

0.408

High

1361436

CNPY2
Protein canopy homolog 2

2

0

Small-scale

0.332

High

1243834

CTR9
RNA polymerase-associated protein CTR9 homolog

2

0

High-throughput

0.328

High

506789

NHLC4
NHL-repeat-containing protein 4

2

0

High-throughput

0.316

High

1206413

EFHC2
EF-hand domain-containing family member C2

2

0

High-throughput

0.316

High

1331075

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

0

High-throughput

0.316

High

1361425

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

1350337

MIPO1
Mirror-image polydactyly gene 1 protein

1

0

High-throughput

0.299

High

47386

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025