HitPredict

Interactor 1: FCG2B (P31994)
Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
Gene: FCGR2B

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.563

Property	Details
Experiments	11453982, 17474147
Identification Methods	unspecified method, peptide array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 310 Hs			1 217
+	Hs
		685214 FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		519376 FCG2A_HUMAN (38-310): 3.57e-58: 191: 73.29		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		722901 CD22_MOUSE (3-308): 2.01e-25: 108: 14.96		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		557621 FCG2B_HUMAN (1-310): 7.03e-74: 231: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		411560 FCG3A_HUMAN (38-272): 1.15e-50: 169: 36.93		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		412047 FCG2B_HUMAN (1-310): 7.03e-74: 231: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		557622 FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		433610 FCG2B_HUMAN (1-310): 7.03e-74: 231: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522811 FCG2B_HUMAN (1-310): 7.03e-74: 231: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		412048 FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		522812 FCG2C_HUMAN (1-310): 1.99e-62: 202: 83.92		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		433545 FCG2A_HUMAN (38-310): 3.57e-58: 191: 73.29		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		434111 ROBO1_HUMAN (2-252): 1.27e-43: 161: 14.44		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Dm
		219802 O44924_DROME (2-167): 3.27e-25: 107: 16.11		ABL_DROME (4-135): 1e-22: 97.4: 37.68
+	Hs
		433507 TUTLB_HUMAN (2-304): 6.34e-33: 130: 15.73		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Mm
		639452 FCRL5_MOUSE (5-253): 1.79e-34: 133: 19.33		LYN_MOUSE (129-215): 2.66e-11: 64.2: 22.47
+	Hs
		434081 TUTLB_HUMAN (2-304): 6.34e-33: 130: 15.73		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		523211 TUTLB_HUMAN (2-304): 6.34e-33: 130: 15.73		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		435878 FCGR1_MOUSE (5-304): 1.63e-24: 104: 16.09		HCK_MOUSE (119-215): 2.26e-11: 64.2: 23.23
+	Hs
		434019 ROBO2_HUMAN (2-125): 1.59e-22: 99.8: 15.91		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47