Protein: ZFHX4
Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4)

Gene: ZFHX4
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q86UP3

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1288837

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

6

High-throughput

0.811

High

1155974

ZFHX3
Zinc finger homeobox protein 3

1

6

High-throughput

0.691

High

1006510

SRPK2
SRSF protein kinase 2

1

4

High-throughput

0.647

High

1132796

CHD4
Chromodomain-helicase-DNA-binding protein 4

3

4

Small-scale

0.640

High

65379

DPRX
Divergent paired-related homeobox

1

16

High-throughput

0.618

High

181532

TBXT
T-box transcription factor T

1

6

High-throughput

0.618

High

210042

CRX
Cone-rod homeobox protein

1

18

High-throughput

0.618

High

225047

TLX3
T-cell leukemia homeobox protein 3

1

16

High-throughput

0.618

High

289159

PRDM1
PR domain zinc finger protein 1

1

18

High-throughput

0.618

High

538428

EGR2
E3 SUMO-protein ligase EGR2

1

17

High-throughput

0.618

High

662245

PAX7
Paired box protein Pax-7

1

18

High-throughput

0.618

High

685253

PAX6
Paired box protein Pax-6

1

14

High-throughput

0.618

High

725280

TLX1
T-cell leukemia homeobox protein 1

1

17

High-throughput

0.618

High

877529

LHX1
LIM/homeobox protein Lhx1

1

12

High-throughput

0.618

High

895746

LHX2
LIM/homeobox protein Lhx2

1

14

High-throughput

0.618

High

920081

PLK1
Serine/threonine-protein kinase PLK1

1

4

High-throughput

0.618

High

942447

GSC
Homeobox protein goosecoid

1

17

High-throughput

0.618

High

1052886

HME1
Homeobox protein engrailed-1

1

9

High-throughput

0.618

High

1160865

TBR1
T-box brain protein 1

1

6

High-throughput

0.618

High

1178667

ISX
Intestine-specific homeobox

1

19

High-throughput

0.618

High

1288836

SP7
Transcription factor Sp7

1

19

High-throughput

0.618

High

1288850

VSX1
Visual system homeobox 1

1

18

High-throughput

0.618

High

1288852

LHX3
LIM/homeobox protein Lhx3

1

12

High-throughput

0.618

High

872485

SOX2
Transcription factor SOX-2

2

15

High-throughput

0.611

High

1091308

FOXL1
Forkhead box protein L1

2

4

High-throughput

0.611

High

350717

NOE2
Noelin-2

2

0

High-throughput

0.602

High

1133504

NFIX
Nuclear factor 1 X-type

2

13

High-throughput

0.584

High

686832

S10A4
Protein S100-A4

1

3

High-throughput

0.536

High

848669

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.536

High

911289

IMA5
Importin subunit alpha-5

1

3

High-throughput

0.536

High

1150240

TEAD2
Transcriptional enhancer factor TEF-4

1

2

High-throughput

0.536

High

1288844

FOXB1
Forkhead box protein B1

1

7

High-throughput

0.536

High

1288851

FOXJ2
Forkhead box protein J2

1

6

High-throughput

0.536

High

1288839

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.515

High

1288854

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

0

High-throughput

0.513

High

1288842

TCPQM
T-complex protein 1 subunit theta-like 2

1

1

High-throughput

0.489

High

143090

NFIB
Nuclear factor 1 B-type

1

11

High-throughput

0.479

High

190073

FOXP2
Forkhead box protein P2

1

10

Small-scale

0.479

High

246721

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.479

High

342237

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.479

High

474099

NFIC
Nuclear factor 1 C-type

1

13

High-throughput

0.479

High

540903

ERG
Transcriptional regulator ERG

1

4

High-throughput

0.479

High

659251

SP100
Nuclear autoantigen Sp-100

1

13

High-throughput

0.479

High

662453

GATA2
Endothelial transcription factor GATA-2

1

5

High-throughput

0.479

High

662602

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

5

High-throughput

0.479

High

703164

TEAD1
Transcriptional enhancer factor TEF-1

1

2

High-throughput

0.479

High

775877

HNF1B
Hepatocyte nuclear factor 1-beta

1

12

High-throughput

0.479

High

776096

SOX5
Transcription factor SOX-5

1

17

High-throughput

0.479

High

776213

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

837063

ELK3
ETS domain-containing protein Elk-3

1

5

High-throughput

0.479

High

855463

ATRX
Transcriptional regulator ATRX

1

6

Small-scale

0.479

High

938470

PAX9
Paired box protein Pax-9

1

11

High-throughput

0.479

High

1040058

PAX2
Paired box protein Pax-2

1

13

High-throughput

0.479

High

1056623

PAX8
Paired box protein Pax-8

1

14

High-throughput

0.479

High

1087839

NFIA
Nuclear factor 1 A-type

1

13

High-throughput

0.479

High

1088425

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

4

High-throughput

0.479

High

1091225

FOXI1
Forkhead box protein I1

1

4

High-throughput

0.479

High

1109854

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.479

High

1113565

CUL3
Cullin-3

1

18

High-throughput

0.479

High

1288835

FOXP4
Forkhead box protein P4

1

11

Small-scale

0.479

High

1288838

PHIP
PH-interacting protein

1

4

High-throughput

0.479

High

1288840

PF21A
PHD finger protein 21A

1

12

High-throughput

0.479

High

1288841

CIC
Protein capicua homolog

1

14

High-throughput

0.479

High

1288843

FEV
Protein FEV

1

4

High-throughput

0.479

High

1288845

SOX7
Transcription factor SOX-7

1

15

High-throughput

0.479

High

1288847

FOXQ1
Forkhead box protein Q1

1

6

High-throughput

0.479

High

1288848

FOXP1
Forkhead box protein P1

1

9

Small-scale

0.479

High

1288853

RCOR1
REST corepressor 1

1

2

High-throughput

0.479

High

1288849

GRHL1
Grainyhead-like protein 1 homolog

1

2

High-throughput

0.445

High

1199561

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1288846

LOXE3
Hydroperoxide isomerase ALOXE3

2

0

High-throughput

0.328

High

420596

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.269

Low

959352

RAP1B
Ras-related protein Rap-1b

1

0

High-throughput

0.269

Low

87498

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025