Protein: ZFHX3
Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3)

Gene: ZFHX3
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q15911

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

154986

BHE40
Class E basic helix-loop-helix protein 40

2

2

High-throughput

0.783

High

576234

PO2F1
POU domain, class 2, transcription factor 1

2

10

High-throughput

0.783

High

772167

MSX2
Homeobox protein MSX-2

2

10

High-throughput

0.783

High

1007927

PO6F2
POU domain, class 6, transcription factor 2

2

11

High-throughput

0.783

High

1155971

ZN620
Zinc finger protein 620

2

7

High-throughput

0.783

High

1115682

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.691

High

1155974

ZFHX4
Zinc finger homeobox protein 4

1

6

High-throughput

0.691

High

1132721

CHD4
Chromodomain-helicase-DNA-binding protein 4

3

5

Small-scale

0.640

High

586300

ZEP1
Zinc finger protein 40

1

7

High-throughput

0.621

High

65376

DPRX
Divergent paired-related homeobox

1

13

High-throughput

0.618

High

210004

CRX
Cone-rod homeobox protein

1

14

High-throughput

0.618

High

225005

TLX3
T-cell leukemia homeobox protein 3

1

19

High-throughput

0.618

High

226555

TLX2
T-cell leukemia homeobox protein 2

1

12

High-throughput

0.618

High

538401

EGR2
E3 SUMO-protein ligase EGR2

1

10

High-throughput

0.618

High

662230

PAX7
Paired box protein Pax-7

1

11

High-throughput

0.618

High

685205

PAX6
Paired box protein Pax-6

1

10

High-throughput

0.618

High

725258

TLX1
T-cell leukemia homeobox protein 1

1

12

High-throughput

0.618

High

851772

NKX21
Homeobox protein Nkx-2.1

1

18

High-throughput

0.618

High

895721

LHX2
LIM/homeobox protein Lhx2

1

11

High-throughput

0.618

High

919991

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.618

High

942436

GSC
Homeobox protein goosecoid

1

14

High-throughput

0.618

High

944661

KLF3
Krueppel-like factor 3

1

17

High-throughput

0.618

High

1155961

TBR1
T-box brain protein 1

1

4

High-throughput

0.618

High

1155995

VSX1
Visual system homeobox 1

1

15

High-throughput

0.618

High

170161

AURKA
Aurora kinase A

1

0

Small-scale

0.614

High

281048

TACC1
Transforming acidic coiled-coil-containing protein 1

2

2

High-throughput

0.606

High

571989

TRI27
Zinc finger protein RFP

2

7

High-throughput

0.606

High

943242

RBM11
Splicing regulator RBM11

2

1

High-throughput

0.606

High

1053402

DEUP1
Deuterosome assembly protein 1

2

4

High-throughput

0.606

High

1061710

TLE5
TLE family member 5

2

5

High-throughput

0.606

High

1155963

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

4

High-throughput

0.606

High

1155976

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

8

High-throughput

0.606

High

1155989

TRI54
Tripartite motif-containing protein 54

2

7

High-throughput

0.606

High

1155992

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

1155994

CNOT2
CCR4-NOT transcription complex subunit 2

2

1

High-throughput

0.606

High

1133431

NFIX
Nuclear factor 1 X-type

2

19

High-throughput

0.584

High

1155968

CYTSA
Cytospin-A

2

0

High-throughput

0.580

High

1155972

CSN6
COP9 signalosome complex subunit 6

2

0

High-throughput

0.580

High

1155991

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

2

0

High-throughput

0.580

High

372131

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.575

High

396196

ESR1
Estrogen receptor

2

19

High-throughput

0.571

High

65050

GG6L9
Golgin subfamily A member 6-like protein 9

2

5

High-throughput

0.553

High

300361

KRT34
Keratin, type I cuticular Ha4

2

6

High-throughput

0.553

High

1042001

LMNB2
Lamin-B2

2

4

High-throughput

0.553

High

1063277

GOGA2
Golgin subfamily A member 2

2

5

High-throughput

0.553

High

1145949

K1H1
Keratin, type I cuticular Ha1

2

6

High-throughput

0.553

High

1155978

CEP70
Centrosomal protein of 70 kDa

2

1

High-throughput

0.553

High

1156000

PIAS3
E3 SUMO-protein ligase PIAS3

1

0

Small-scale

0.549

High

1155970

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

3

High-throughput

0.536

High

1155979

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

1

High-throughput

0.536

High

1155988

TCAB1
Telomerase Cajal body protein 1

1

3

High-throughput

0.536

High

1155996

TRPS1
Zinc finger transcription factor Trps1

1

8

High-throughput

0.536

High

1155969

K1C40
Keratin, type I cytoskeletal 40

1

6

High-throughput

0.523

High

158917

CCS
Copper chaperone for superoxide dismutase

1

0

High-throughput

0.513

High

224004

GET3
ATPase GET3

1

0

High-throughput

0.513

High

1155965

BEND3
BEN domain-containing protein 3

1

0

High-throughput

0.513

High

1155993

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

1

0

Small-scale

0.486

High

1155981

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

280636

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

Small-scale

0.480

High

143016

NFIB
Nuclear factor 1 B-type

1

17

High-throughput

0.479

High

408897

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

4

High-throughput

0.479

High

474017

NFIC
Nuclear factor 1 C-type

1

18

High-throughput

0.479

High

520087

ANDR
Androgen receptor

1

18

High-throughput

0.479

High

662430

GATA2
Endothelial transcription factor GATA-2

1

6

High-throughput

0.479

High

703150

TEAD1
Transcriptional enhancer factor TEF-1

1

2

High-throughput

0.479

High

775846

HNF1B
Hepatocyte nuclear factor 1-beta

1

13

High-throughput

0.479

High

776074

SOX5
Transcription factor SOX-5

1

18

High-throughput

0.479

High

776198

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

872369

SOX2
Transcription factor SOX-2

1

17

High-throughput

0.479

High

938453

PAX9
Paired box protein Pax-9

1

10

High-throughput

0.479

High

942637

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

5

High-throughput

0.479

High

998360

H31
Histone H3.1

1

6

High-throughput

0.479

High

1047981

TLE3
Transducin-like enhancer protein 3

1

8

High-throughput

0.479

High

1087764

NFIA
Nuclear factor 1 A-type

1

18

High-throughput

0.479

High

1088370

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

5

High-throughput

0.479

High

1091288

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.479

High

1109761

HDAC1
Histone deacetylase 1

1

10

High-throughput

0.479

High

1125117

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

8

Small-scale

0.479

High

1155977

NUP43
Nucleoporin Nup43

1

9

High-throughput

0.479

High

1155980

PHIP
PH-interacting protein

1

7

High-throughput

0.479

High

1155982

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

1155983

PF21A
PHD finger protein 21A

1

14

High-throughput

0.479

High

1155984

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

3

High-throughput

0.479

High

1155986

CIC
Protein capicua homolog

1

17

High-throughput

0.479

High

1155987

FEV
Protein FEV

1

7

High-throughput

0.479

High

1155997

RCOR1
REST corepressor 1

1

5

High-throughput

0.479

High

1155962

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

178022

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

0

High-throughput

0.458

High

378494

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

558167

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

827800

STAT3
Signal transducer and activator of transcription 3

1

0

Small-scale

0.458

High

975056

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

1155966

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1155973

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1155998

NINL
Ninein-like protein

1

5

High-throughput

0.439

High

1155964

EFHC2
EF-hand domain-containing family member C2

2

0

High-throughput

0.316

High

1155967

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

1155975

USBP1
Harmonin-binding protein USHBP1

2

0

High-throughput

0.316

High

1155985

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

0

High-throughput

0.313

High

1155990

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.279

Low

1155999

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.279

Low

353356

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025