HitPredict

Interactor 1: U2AF2 (P26368)
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)
Gene: U2AF2

Interactor 2: RC3H2 (Q9HBD1)
Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)
Gene: RC3H2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30209976
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~zf-CCCH
Common GO terms	GO:0003723 - RNA binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 475 Hs			1 1191
+	Hs
		1152641 ELAV1_HUMAN (149-471): 2.79e-73: 235: 14.79		RC3H2_HUMAN (1-1191): 0: 1091: 100.00
+	Hs
		1127173 RBM39_HUMAN (10-471): 4.96e-48: 175: 19.16		RC3H2_HUMAN (1-1191): 0: 1091: 100.00
+	Hs
		726804 TIA1_HUMAN (253-475): 7.07e-37: 141: 16.14		RC3H2_HUMAN (1-1191): 0: 1091: 100.00
+	Hs
		1438070 PUF60_HUMAN (92-474): 7.88e-23: 103: 21.50		RC3H2_HUMAN (1-1191): 0: 1091: 100.00
+	Hs
		1102102 PABP4_HUMAN (41-251): 1.15e-19: 94.2: 12.78		RC3H2_HUMAN (1-1191): 0: 1091: 100.00
+	Hs
		550473 PABP1_HUMAN (41-247): 2e-19: 93.4: 14.35		RC3H2_HUMAN (1-1191): 0: 1091: 100.00
+	Hs
		1432507 PABP3_HUMAN (43-247): 6.77e-19: 91.5: 14.93		RC3H2_HUMAN (1-1191): 0: 1091: 100.00
+	Hs
		685604 U2AF2_HUMAN (1-475): 2.14e-95: 297: 100.00		RC3H1_HUMAN (1-1101): 0: 764: 49.34
+	Hs
		1137063 SART3_HUMAN (10-377): 4.35e-86: 285: 22.52		RC3H1_HUMAN (1-1101): 0: 764: 49.34
+	Hs
		1152525 ELAV1_HUMAN (149-471): 2.79e-73: 235: 14.79		RC3H1_HUMAN (1-1101): 0: 764: 49.34
+	Hs
		1126943 RBM39_HUMAN (10-471): 4.96e-48: 175: 19.16		RC3H1_HUMAN (1-1101): 0: 764: 49.34
+	Hs
		1215881 PUF60_HUMAN (92-474): 7.88e-23: 103: 21.50		RC3H1_HUMAN (1-1101): 0: 764: 49.34
+	Hs
		1101989 PABP4_HUMAN (41-251): 1.15e-19: 94.2: 12.78		RC3H1_HUMAN (1-1101): 0: 764: 49.34
+	Hs
		550320 PABP1_HUMAN (41-247): 2e-19: 93.4: 14.35		RC3H1_HUMAN (1-1101): 0: 764: 49.34
+	Hs
		1215826 PABP3_HUMAN (43-247): 6.77e-19: 91.5: 14.93		RC3H1_HUMAN (1-1101): 0: 764: 49.34
+	Hs
		590245 U2AF2_HUMAN (1-475): 2.14e-95: 297: 100.00		MUC1_HUMAN (344-859): 9.41e-17: 88.2: 9.85
+	Dm
		402265 U2AF2_DROME (84-474): 5.35e-70: 230: 68.35		RPB1_DROME (598-967): 1.51e-10: 68.1: 12.85
+	Hs
		1126882 RBM39_HUMAN (10-471): 4.96e-48: 175: 19.16		MDC1_HUMAN (442-806): 1.15e-11: 71.8: 12.21
+	Hs
		550367 PABP1_HUMAN (41-247): 2e-19: 93.4: 14.35		KMT2C_HUMAN (340-929): 3.43e-15: 83.5: 10.15