HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2)
Gene: MTOR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	35271311, 36931259, 15161933, 10664457
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0044325 - transmembrane transporter binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 2549
+	Hs
		839224 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		839235 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		729660 1433B_HUMAN (1-242): 5.04e-139: 391: 81.82		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		730429 1433S_HUMAN (1-236): 9.9e-108: 312: 71.85		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		839245 1433F_HUMAN (2-242): 7.19e-106: 307: 71.43		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		839222 1433G_HUMAN (1-242): 5.51e-105: 305: 70.33		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		990181 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		ATM_HUMAN (387-2548): 0: 894: 14.98
+	Hs
		730389 1433B_HUMAN (1-242): 5.04e-139: 391: 81.82		TRRAP_HUMAN (925-2548): 0: 720: 15.53
+	At
		840509 14333_ARATH (3-243): 8.04e-143: 401: 61.63		ATM_ARATH (401-2548): 0: 704: 13.98
+	Hs
		690899 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		PRKDC_HUMAN (695-2548): 0: 686: 14.83
+	Hs
		990090 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		PRKDC_HUMAN (695-2548): 0: 686: 14.83
+	Hs
		729742 1433B_HUMAN (1-242): 5.04e-139: 391: 81.82		PRKDC_HUMAN (695-2548): 0: 686: 14.83
+	Hs
		967061 1433G_HUMAN (1-242): 5.51e-105: 305: 70.33		TRRAP_HUMAN (925-2548): 0: 720: 15.53
+	Hs
		966190 1433G_HUMAN (1-242): 5.51e-105: 305: 70.33		PRKDC_HUMAN (695-2548): 0: 686: 14.83
+	Hs
		1049356 1433F_HUMAN (2-242): 7.19e-106: 307: 71.43		Q4LE69_HUMAN (733-2453): 1.64e-160: 553: 12.12
+	Hs
		966397 1433G_HUMAN (1-242): 5.51e-105: 305: 70.33		Q4LE69_HUMAN (733-2453): 1.64e-160: 553: 12.12
+	Hs
		691301 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17
+	Hs
		990563 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17
+	Dm
		709539 1433Z_DROME (1-245): 3.69e-141: 397: 77.14		Q7K3H0_DROME (1898-2419): 8.52e-26: 119: 19.33