HitPredict

Interactor 1: RPN2 (P32565)
26S proteasome regulatory subunit RPN2
Gene: RPN2

Interactor 2: RPN3 (P40016)
26S proteasome regulatory subunit RPN3
Gene: RPN3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	37968396, 16554755, 22307589, 22940862
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HEAT_2~Rpn3_C
Common GO terms	GO:0000502 - proteasome complex GO:0006511 - ubiquitin-dependent protein catabolic process GO:0030234 - enzyme regulator activity GO:0042176 - regulation of protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 945 Sc			1 523
+	Hs
		198698 PSMD1_HUMAN (3-926): 0: 1116: 39.98		PSMD3_HUMAN (9-513): 0: 546: 30.71
+	Hs
		680 A0A087WW66_HUMAN (3-926): 0: 1016: 36.69		PSMD3_HUMAN (9-513): 0: 546: 30.71
+	Dm
		627133 PSMD1_DROME (1-927): 0: 990: 36.04		PSMD3_DROME (1-513): 0: 521: 31.40
+	Hs
		198613 PSMD2_HUMAN (9-770): 0: 760: 17.31		PSMD3_HUMAN (9-513): 0: 546: 30.71
+	At
		1338930 PSD2A_ARATH (9-770): 0: 669: 17.76		PSD3A_ARATH (3-513): 1.12e-179: 515: 31.21
+	Dm
		627145 Q9VW54_DROME (13-770): 0: 651: 17.61		PSMD3_DROME (1-513): 0: 521: 31.40
+	Sp
		194816 RPN1_SCHPO (9-770): 0: 621: 18.33		RPN3_SCHPO (7-517): 1.37e-167: 485: 37.24
+	Sc
		753820 RPN1_YEAST (9-573): 1.13e-134: 430: 17.33		RPN3_YEAST (1-523): 0: 582: 100.00