Protein: BMAL1
Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3)

Gene: BMAL1
Organism: Homo sapiens
Interactions: 105
UniProt ID: O00327

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

132684

CLOCK
Circadian locomoter output cycles protein kaput

15

19

Small-scale

0.983

High

132762

NPAS2
Neuronal PAS domain-containing protein 2

8

19

Small-scale

0.969

High

132763

EPAS1
Endothelial PAS domain-containing protein 1

3

19

Small-scale

0.839

High

132752

BMAL2
Basic helix-loop-helix ARNT-like protein 2

2

20

High-throughput

0.811

High

132727

CRY1
Cryptochrome-1

4

18

Small-scale

0.688

High

132703

AHR
Aryl hydrocarbon receptor

1

19

Small-scale

0.680

High

92030

D0VY79
Hypoxia-inducible factor 1-alpha

1

19

High-throughput

0.665

High

132778

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

4

High-throughput

0.628

High

132745

NPAS4
Neuronal PAS domain-containing protein 4

1

19

Small-scale

0.621

High

132681

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

19

Small-scale

0.618

High

132683

PER2
Period circadian protein homolog 2

1

19

Small-scale

0.618

High

132710

MAX
Protein max

1

8

High-throughput

0.618

High

132729

H31T
Histone H3.1t

1

2

High-throughput

0.618

High

132706

KC1E
Casein kinase I isoform epsilon

2

18

Small-scale

0.594

High

132728

HIF1A
Hypoxia-inducible factor 1-alpha

1

19

High-throughput

0.590

High

132717

CSK2B
Casein kinase II subunit beta

2

6

Small-scale

0.586

High

132730

CRY2
Cryptochrome-2

2

18

Small-scale

0.586

High

132719

UBE3A
Ubiquitin-protein ligase E3A

2

6

Small-scale

0.584

High

132753

CBP
CREB-binding protein

2

20

Small-scale

0.584

High

132682

AZIN1
Antizyme inhibitor 1

2

0

High-throughput

0.580

High

132751

TPC12
Trafficking protein particle complex subunit 12

2

0

High-throughput

0.580

High

132711

RHOA
Transforming protein RhoA

1

2

Small-scale

0.561

High

132718

CSK21
Casein kinase II subunit alpha

1

7

Small-scale

0.561

High

132756

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

13

Small-scale

0.561

High

132777

CHIP
E3 ubiquitin-protein ligase CHIP

1

15

Small-scale

0.561

High

132758

DHTK1
2-oxoadipate dehydrogenase complex component E1

2

1

High-throughput

0.553

High

132708

RORG
Nuclear receptor ROR-gamma

1

20

High-throughput

0.552

High

132712

WDR5
WD repeat-containing protein 5

1

7

High-throughput

0.552

High

132709

NEK4
Serine/threonine-protein kinase Nek4

1

3

High-throughput

0.536

High

132766

CIPC
CLOCK-interacting pacemaker

1

4

High-throughput

0.536

High

132697

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.515

High

132746

P20D2
Xaa-Arg dipeptidase

1

0

High-throughput

0.513

High

132692

HS90A
Heat shock protein HSP 90-alpha

1

19

Small-scale

0.501

High

132694

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.501

High

132699

RXRA
Retinoic acid receptor RXR-alpha

1

20

Small-scale

0.501

High

132720

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.501

High

132754

KAT2B
Histone acetyltransferase KAT2B

1

10

Small-scale

0.501

High

127826

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

Small-scale

0.479

High

128098

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

1

Small-scale

0.479

High

128350

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

1

High-throughput

0.479

High

132685

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

Small-scale

0.479

High

132686

MS18B
Protein Mis18-beta

1

1

High-throughput

0.479

High

132687

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

1

3

Small-scale

0.479

High

132688

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

132689

YETS4
YEATS domain-containing protein 4

1

1

High-throughput

0.479

High

132690

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

132691

JUN
Transcription factor Jun

1

13

High-throughput

0.479

High

132693

TFPT
TCF3 fusion partner

1

1

High-throughput

0.479

High

132695

EF2
Elongation factor 2

1

2

High-throughput

0.479

High

132696

ZNF44
Zinc finger protein 44

1

1

Small-scale

0.479

High

132698

PRS6A
26S proteasome regulatory subunit 6A

1

10

Small-scale

0.479

High

132700

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

132701

PSB1
Proteasome subunit beta type-1

1

4

Small-scale

0.479

High

132704

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

Small-scale

0.479

High

132713

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

8

High-throughput

0.479

High

132714

PRS8
26S proteasome regulatory subunit 8

1

5

Small-scale

0.479

High

132715

PRS10
26S proteasome regulatory subunit 10B

1

5

Small-scale

0.479

High

132716

H4
Histone H4

1

6

High-throughput

0.479

High

132721

TBL3
Transducin beta-like protein 3

1

9

Small-scale

0.479

High

132722

TRAF2
TNF receptor-associated factor 2

1

13

Small-scale

0.479

High

132723

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

4

Small-scale

0.479

High

132724

CUL1
Cullin-1

1

9

Small-scale

0.479

High

132725

GIT2
ARF GTPase-activating protein GIT2

1

3

High-throughput

0.479

High

132726

ZN174
Zinc finger protein 174

1

1

Small-scale

0.479

High

132731

GRAP1
GRIP1-associated protein 1

1

10

High-throughput

0.479

High

132732

CCD93
Coiled-coil domain-containing protein 93

1

1

High-throughput

0.479

High

132733

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

1

High-throughput

0.479

High

132735

CAVN1
Caveolae-associated protein 1

1

3

High-throughput

0.479

High

132736

PKN3
Serine/threonine-protein kinase N3

1

8

High-throughput

0.479

High

132741

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

Small-scale

0.479

High

132742

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

Small-scale

0.479

High

132743

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

7

Small-scale

0.479

High

132748

UBP38
Ubiquitin carboxyl-terminal hydrolase 38

1

12

Small-scale

0.479

High

132750

CCHCR
Coiled-coil alpha-helical rod protein 1

1

9

High-throughput

0.479

High

132755

PF21A
PHD finger protein 21A

1

7

High-throughput

0.479

High

132757

THA11
THAP domain-containing protein 11

1

1

High-throughput

0.479

High

132760

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

2

High-throughput

0.479

High

132761

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

4

Small-scale

0.479

High

132764

NUF2
Kinetochore protein Nuf2

1

2

High-throughput

0.479

High

132765

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

9

Small-scale

0.479

High

132767

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

Small-scale

0.479

High

132771

HM20A
High mobility group protein 20A

1

16

High-throughput

0.479

High

132773

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

1

High-throughput

0.479

High

132774

RABX5
Rab5 GDP/GTP exchange factor

1

4

High-throughput

0.479

High

132775

RCOR1
REST corepressor 1

1

8

High-throughput

0.479

High

132776

PSME2
Proteasome activator complex subunit 2

1

1

Small-scale

0.479

High

132779

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

3

Small-scale

0.479

High

132702

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

Small-scale

0.458

High

132705

MTR1B
Melatonin receptor type 1B

1

0

Small-scale

0.458

High

132739

CSN6
COP9 signalosome complex subunit 6

1

0

Small-scale

0.458

High

132738

RHOU
Rho-related GTP-binding protein RhoU

1

5

High-throughput

0.457

High

132747

STAG2
Cohesin subunit SA-2

1

1

Small-scale

0.445

High

132772

DEC1
Deleted in esophageal cancer 1

1

3

High-throughput

0.439

High

85215

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

1

High-throughput

0.437

High

132734

PHLB3
Pleckstrin homology-like domain family B member 3

1

3

High-throughput

0.437

High

132740

HAUS6
HAUS augmin-like complex subunit 6

1

2

High-throughput

0.437

High

132744

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

10

High-throughput

0.437

High

132749

GOGA5
Golgin subfamily A member 5

1

12

High-throughput

0.437

High

132759

VPS50
Syndetin

1

1

High-throughput

0.437

High

132769

NCK5L
Nck-associated protein 5-like

1

1

High-throughput

0.437

High

132770

TUFT1
Tuftelin

1

1

High-throughput

0.437

High

132707

BCAM
Basal cell adhesion molecule

2

0

High-throughput

0.328

High

132737

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

2

0

High-throughput

0.328

High

132768

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025