Protein: EPAS1
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)

Gene: EPAS1
Organism: Homo sapiens
Interactions: 167
UniProt ID: Q99814

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 - transcription coactivator binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

822832

VHL
von Hippel-Lindau disease tumor suppressor

21

8

Small-scale

0.988

High

693356

ARNT
Aryl hydrocarbon receptor nuclear translocator

16

20

Small-scale

0.987

High

1407414

EGLN1
Egl nine homolog 1

7

14

Small-scale

0.959

High

1067644

EP300
Histone acetyltransferase p300

4

20

Small-scale

0.885

High

1407416

EGLN3
Prolyl hydroxylase EGLN3

3

14

Small-scale

0.844

High

132763

BMAL1
Basic helix-loop-helix ARNT-like protein 1

3

19

Small-scale

0.839

High

1361504

BMAL2
Basic helix-loop-helix ARNT-like protein 2

3

19

Small-scale

0.839

High

1407420

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

2

19

Small-scale

0.793

High

1396431

EGLN2
Prolyl hydroxylase EGLN2

2

14

Small-scale

0.785

High

1407406

EPAS1
Endothelial PAS domain-containing protein 1

2

19

Small-scale

0.768

High

1368464

CBP
CREB-binding protein

2

20

Small-scale

0.754

High

419163

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.691

High

959645

MAX
Protein max

1

8

Small-scale

0.665

High

1407441

NEMO
NF-kappa-B essential modulator

2

16

Small-scale

0.651

High

269118

MITF
Microphthalmia-associated transcription factor

1

19

Small-scale

0.618

High

1155126

USF2
Upstream stimulatory factor 2

1

9

Small-scale

0.618

High

1161374

HIF1A
Hypoxia-inducible factor 1-alpha

1

20

Small-scale

0.618

High

1407437

HIF3A
Hypoxia-inducible factor 3-alpha

1

19

Small-scale

0.618

High

1112969

CUL2
Cullin-2

2

9

Small-scale

0.611

High

1147259

ELOB
Elongin-B

2

2

Small-scale

0.611

High

1407435

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

12

High-throughput

0.606

High

461864

HS90A
Heat shock protein HSP 90-alpha

2

17

Small-scale

0.595

High

465031

SP1
Transcription factor Sp1

2

10

Small-scale

0.584

High

482532

F16P1
Fructose-1,6-bisphosphatase 1

1

1

Small-scale

0.578

High

396800

ESR1
Estrogen receptor

1

20

Small-scale

0.573

High

577870

PLAK
Junction plakoglobin

1

18

Small-scale

0.561

High

828244

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

8

Small-scale

0.561

High

1132927

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

5

Small-scale

0.561

High

1388706

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

8

Small-scale

0.561

High

1405662

NECD
Necdin

1

15

Small-scale

0.561

High

1401481

BBS4
BBSome complex member BBS4

1

2

Small-scale

0.552

High

1407427

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.552

High

1407436

KLH20
Kelch-like protein 20

1

3

Small-scale

0.552

High

668703

APC
Adenomatous polyposis coli protein

1

6

High-throughput

0.541

High

1055030

MEF2C
Myocyte-specific enhancer factor 2C

1

1

High-throughput

0.541

High

424252

S10A8
Protein S100-A8

1

5

High-throughput

0.536

High

445054

S10A9
Protein S100-A9

1

5

High-throughput

0.536

High

667426

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.536

High

1147111

ELOC
Elongin-C

1

2

High-throughput

0.536

High

1407422

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

2

High-throughput

0.536

High

1407424

RNC
Ribonuclease 3

1

2

Small-scale

0.536

High

949428

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

1

Small-scale

0.529

High

1277551

UBE3B
Ubiquitin-protein ligase E3B

1

5

Small-scale

0.528

High

192848

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.513

High

370353

CYTA
Cystatin-A

1

0

High-throughput

0.513

High

621726

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.513

High

621948

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

787777

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.513

High

912112

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.513

High

976140

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.513

High

1407410

RBM4
RNA-binding protein 4

1

0

Small-scale

0.513

High

366434

FA12
Coagulation factor XII

1

3

Small-scale

0.512

High

1014596

SMAD3
Mothers against decapentaplegic homolog 3

1

8

High-throughput

0.508

High

138757

IMA4
Importin subunit alpha-4

1

13

Small-scale

0.501

High

179075

IMA6
Importin subunit alpha-6

1

13

Small-scale

0.501

High

253683

IMA7
Importin subunit alpha-7

1

13

Small-scale

0.501

High

430279

JUN
Transcription factor Jun

1

12

High-throughput

0.501

High

846929

ETV4
ETS translocation variant 4

1

16

Small-scale

0.501

High

911355

IMA5
Importin subunit alpha-5

1

13

Small-scale

0.501

High

1083492

DBP
D site-binding protein

1

9

High-throughput

0.501

High

1134353

IMB1
Importin subunit beta-1

1

2

Small-scale

0.501

High

1157637

BATF
Basic leucine zipper transcriptional factor ATF-like

1

8

High-throughput

0.501

High

1323664

BATF2
Basic leucine zipper transcriptional factor ATF-like 2

1

2

High-throughput

0.501

High

1407423

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

1

9

High-throughput

0.501

High

252149

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

Small-scale

0.500

High

953974

IF4A1
Eukaryotic initiation factor 4A-I

1

1

Small-scale

0.500

High

1340032

OR6K3
Olfactory receptor 6K3

1

1

High-throughput

0.489

High

1339327

BBS1
BBSome complex member BBS1

1

0

Small-scale

0.486

High

1407412

BBS2
BBSome complex member BBS2

1

0

Small-scale

0.486

High

838386

STA5A
Signal transducer and activator of transcription 5A

1

6

High-throughput

0.481

High

1033182

EWS
RNA-binding protein EWS

1

4

High-throughput

0.481

High

775464

DDIT3
DNA damage-inducible transcript 3 protein

1

0

High-throughput

0.480

High

928530

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.480

High

167962

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

7

Small-scale

0.479

High

173272

XPO1
Exportin-1

1

8

Small-scale

0.479

High

239611

MED14
Mediator of RNA polymerase II transcription subunit 14

1

14

Small-scale

0.479

High

246901

KDM1A
Lysine-specific histone demethylase 1A

1

6

Small-scale

0.479

High

259067

DNJA2
DnaJ homolog subfamily A member 2

1

11

Small-scale

0.479

High

297858

PIAS2
E3 SUMO-protein ligase PIAS2

1

5

Small-scale

0.479

High

327640

ELP1
Elongator complex protein 1

1

1

Small-scale

0.479

High

347280

BAG2
BAG family molecular chaperone regulator 2

1

5

Small-scale

0.479

High

431604

AP2A
Transcription factor AP-2-alpha

1

1

Small-scale

0.479

High

508506

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

Small-scale

0.479

High

519554

MYBB
Myb-related protein B

1

1

Small-scale

0.479

High

540643

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

Small-scale

0.479

High

558363

XRCC6
X-ray repair cross-complementing protein 6

1

5

Small-scale

0.479

High

559474

XRCC5
X-ray repair cross-complementing protein 5

1

5

Small-scale

0.479

High

573222

KPYM
Pyruvate kinase PKM

1

3

Small-scale

0.479

High

577496

ETS1
Protein C-ets-1

1

17

Small-scale

0.479

High

610451

PRS6A
26S proteasome regulatory subunit 6A

1

12

Small-scale

0.479

High

622474

ELK1
ETS domain-containing protein Elk-1

1

17

Small-scale

0.479

High

633778

PSB1
Proteasome subunit beta type-1

1

4

Small-scale

0.479

High

669986

MCM3
DNA replication licensing factor MCM3

1

6

Small-scale

0.479

High

756316

MCM7
DNA replication licensing factor MCM7

1

3

Small-scale

0.479

High

761844

HSP74
Heat shock 70 kDa protein 4

1

8

Small-scale

0.479

High

764991

CTNB1
Catenin beta-1

1

20

Small-scale

0.479

High

766792

PHB1
Prohibitin 1

1

1

Small-scale

0.479

High

841236

CNDD3
Condensin-2 complex subunit D3

1

1

Small-scale

0.479

High

903244

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

9

Small-scale

0.479

High

903467

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

9

Small-scale

0.479

High

942122

SOX10
Transcription factor SOX-10

1

20

Small-scale

0.479

High

964723

DCAF7
DDB1- and CUL4-associated factor 7

1

4

Small-scale

0.479

High

991410

SUMO1
Small ubiquitin-related modifier 1

1

3

Small-scale

0.479

High

992931

RACK1
Small ribosomal subunit protein RACK1

1

11

Small-scale

0.479

High

1008308

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

Small-scale

0.479

High

1035865

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

1060128

BAX
Apoptosis regulator BAX

1

5

Small-scale

0.479

High

1086685

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

Small-scale

0.479

High

1100294

TIF1B
Transcription intermediary factor 1-beta

1

12

Small-scale

0.479

High

1108083

SQSTM
Sequestosome-1

1

2

Small-scale

0.479

High

1110032

HDAC1
Histone deacetylase 1

1

9

Small-scale

0.479

High

1151288

MED1
Mediator of RNA polymerase II transcription subunit 1

1

14

Small-scale

0.479

High

1199453

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

13

Small-scale

0.479

High

1232983

OTU7B
OTU domain-containing protein 7B

1

2

Small-scale

0.479

High

1287008

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

14

Small-scale

0.479

High

1292508

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

7

Small-scale

0.479

High

1338756

ARI1B
AT-rich interactive domain-containing protein 1B

1

2

Small-scale

0.479

High

1339520

TET1
Methylcytosine dioxygenase TET1

1

1

Small-scale

0.479

High

1347535

SMRC2
SWI/SNF complex subunit SMARCC2

1

15

Small-scale

0.479

High

1353416

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

14

Small-scale

0.479

High

1368084

HDAC2
Histone deacetylase 2

1

8

Small-scale

0.479

High

1368364

REQU
Zinc finger protein ubi-d4

1

8

Small-scale

0.479

High

1370692

SMRC1
SWI/SNF complex subunit SMARCC1

1

8

Small-scale

0.479

High

1372185

MED12
Mediator of RNA polymerase II transcription subunit 12

1

19

Small-scale

0.479

High

1384339

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

1

3

Small-scale

0.479

High

1391331

MED8
Mediator of RNA polymerase II transcription subunit 8

1

1

Small-scale

0.479

High

1401562

MED15
Mediator of RNA polymerase II transcription subunit 15

1

20

Small-scale

0.479

High

1403007

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.479

High

1404562

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

4

Small-scale

0.479

High

1406002

PHB2
Prohibitin-2

1

1

Small-scale

0.479

High

1407411

SSBP3
Single-stranded DNA-binding protein 3

1

1

Small-scale

0.479

High

1407419

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

11

Small-scale

0.479

High

1407428

MED11
Mediator of RNA polymerase II transcription subunit 11

1

1

Small-scale

0.479

High

1407431

MED23
Mediator of RNA polymerase II transcription subunit 23

1

2

Small-scale

0.479

High

1407433

CHIP
E3 ubiquitin-protein ligase CHIP

1

14

Small-scale

0.479

High

1407434

TRI33
E3 ubiquitin-protein ligase TRIM33

1

16

Small-scale

0.479

High

1407439

YTHD2
YTH domain-containing family protein 2

1

1

Small-scale

0.479

High

1407440

TF3C3
General transcription factor 3C polypeptide 3

1

3

Small-scale

0.479

High

64099

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

Small-scale

0.458

High

219508

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

Small-scale

0.458

High

282413

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

Small-scale

0.458

High

336024

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

Small-scale

0.458

High

447354

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

895002

EMD
Emerin

1

0

Small-scale

0.458

High

1149704

MED22
Mediator of RNA polymerase II transcription subunit 22

1

0

Small-scale

0.458

High

1241406

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

Small-scale

0.458

High

1259272

MED25
Mediator of RNA polymerase II transcription subunit 25

1

0

Small-scale

0.458

High

1357465

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

0

Small-scale

0.458

High

1407407

MED10
Mediator of RNA polymerase II transcription subunit 10

1

0

Small-scale

0.458

High

1407408

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

Small-scale

0.458

High

1407409

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

1407413

DPY30
Protein dpy-30 homolog

1

0

Small-scale

0.458

High

1407415

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

0

Small-scale

0.458

High

1407417

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

Small-scale

0.458

High

1407418

CNO10
CCR4-NOT transcription complex subunit 10

1

0

Small-scale

0.458

High

1407421

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

Small-scale

0.458

High

1407425

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

Small-scale

0.458

High

1407426

MED29
Mediator of RNA polymerase II transcription subunit 29

1

0

Small-scale

0.458

High

1407430

CNOT7
CCR4-NOT transcription complex subunit 7

1

0

Small-scale

0.458

High

1407432

AKP8L
A-kinase anchor protein 8-like

1

0

Small-scale

0.458

High

1407438

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

Small-scale

0.458

High

1402241

WRIP1
ATPase WRNIP1

1

5

Small-scale

0.437

High

1407429

XPO7
Exportin-7

1

6

High-throughput

0.437

High

457983

TRY1
Serine protease 1

1

0

High-throughput

0.279

Low

522292

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

1142638

PDK1
[Pyruvate dehydrogenase

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025