HitPredict

Interactor 1: BRR2 (P32639)
Pre-mRNA-splicing helicase BRR2 (EC 3.6.4.13) (Protein Snu246)
Gene: BRR2

Interactor 2: LSM7 (P53905)
U6 snRNA-associated Sm-like protein LSm7
Gene: LSM7

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.724

Property	Details
Experiments	25670679, 11720284, 10449419, 18953335, 16429126, 37968396
Identification Methods	affinity chromatography technology, biochemical, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0046540 - U4/U6 x U5 tri-snRNP complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2163 Sc			1 115
+	Hs
		272095 U520_HUMAN (16-2163): 0: 1597: 38.84		RSMN_HUMAN (23-103): 1.07e-28: 105: 28.40
+	Hs
		272026 U520_HUMAN (16-2163): 0: 1597: 38.84		RSMB_HUMAN (23-103): 1.03e-27: 103: 28.40
+	Hs
		272090 U520_HUMAN (16-2163): 0: 1597: 38.84		RUXG_HUMAN (24-107): 3.5e-23: 86.9: 33.33
+	Hs
		271997 U520_HUMAN (16-2163): 0: 1597: 38.84		LSM8_HUMAN (30-110): 1.17e-21: 83.4: 24.69
+	Hs
		68389 U520_HUMAN (16-2163): 0: 1597: 38.84		RUXGL_HUMAN (24-107): 5.73e-21: 81.1: 32.14
+	Sc
		697241 BRR2_YEAST (1-2163): 0: 1534: 100.00		LSM3_YEAST (25-110): 2.58e-21: 82.7: 31.03
+	Sc
		697213 BRR2_YEAST (1-2163): 0: 1534: 100.00		RSMB_YEAST (23-107): 9.03e-19: 78.9: 28.13
+	Sc
		697217 BRR2_YEAST (1-2163): 0: 1534: 100.00		RUXG_YEAST (26-106): 1.83e-18: 75: 34.57
+	Sp
		1013610 BRR2_SCHPO (5-2162): 0: 1396: 41.00		RSMB_SCHPO (29-103): 7.22e-26: 95.8: 30.67
+	Sp
		252602 BRR2_SCHPO (5-2162): 0: 1396: 41.00		RUXG_SCHPO (24-108): 1.43e-20: 80.4: 30.59
+	Hs
		539083 DDX17_HUMAN (1345-1753): 1.1e-96: 332: 11.35		RSMB_HUMAN (23-103): 1.03e-27: 103: 28.40
+	Hs
		538973 SKI2_HUMAN (381-921): 1.04e-88: 320: 19.36		RSMB_HUMAN (23-103): 1.03e-27: 103: 28.40
+	Hs
		538830 DDX5_HUMAN (1344-1752): 6.23e-93: 317: 11.35		RSMB_HUMAN (23-103): 1.03e-27: 103: 28.40
+	Sp
		143150 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		RSMB_SCHPO (29-103): 7.22e-26: 95.8: 30.67
+	Hs
		928011 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		RSMN_HUMAN (23-103): 1.07e-28: 105: 28.40
+	Hs
		1313213 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		LSM7_HUMAN (18-111): 2.12e-29: 103: 46.81
+	Hs
		539132 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		RSMB_HUMAN (23-103): 1.03e-27: 103: 28.40
+	Sp
		143052 YE02_SCHPO (377-925): 4.47e-87: 311: 21.59		RUXG_SCHPO (24-108): 1.43e-20: 80.4: 30.59
+	Hs
		912103 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		RUXG_HUMAN (24-107): 3.5e-23: 86.9: 33.33
+	Hs
		68454 DDX23_HUMAN (1275-1768): 3.27e-82: 292: 13.30		RUXGL_HUMAN (24-107): 5.73e-21: 81.1: 32.14