HitPredict

Interactor 1: FAK1 (P34152)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: Ptk2

Interactor 2: BCAR1 (Q61140)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas)
Gene: BCAR1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.860

The method score is based on:

Property Details
Experiments 9038154, 7479864, 18233957
Identification Methods affinity chromatography technology, two hybrid, coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH3_1
Common GO terms GO:0005829 - cytosol
GO:0005925 - focal adhesion
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0007229 - integrin-mediated signaling pathway
GO:0016477 - cell migration
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1052
Mm

1 874
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024