Protein: AP3S1
AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a)

Gene: AP3S1
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q92572

Gene Ontology (top 5):
GO:0005769 - early endosome
GO:0005794 - Golgi apparatus
GO:0006886 - intracellular protein transport
GO:0006896 - Golgi to vacuole transport
GO:0008089 - anterograde axonal transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

158862

AP3D1
AP-3 complex subunit delta-1

8

20

Small-scale

0.966

High

1364946

AP3M1
AP-3 complex subunit mu-1

3

20

High-throughput

0.855

High

126157

AP3B1
AP-3 complex subunit beta-1

2

20

High-throughput

0.811

High

922549

AP3M2
AP-3 complex subunit mu-2

2

20

High-throughput

0.811

High

1103493

AP3B2
AP-3 complex subunit beta-2

2

20

High-throughput

0.811

High

220512

RNF13
E3 ubiquitin-protein ligase RNF13

4

4

Small-scale

0.703

High

1364922

DTBP1
Dysbindin

3

2

High-throughput

0.667

High

1364940

KLK11
Kallikrein-11

3

2

High-throughput

0.667

High

320481

TM63A
Mechanosensitive cation channel TMEM63A

3

2

High-throughput

0.662

High

1364936

AGO3
Protein argonaute-3

3

2

High-throughput

0.609

High

1364943

VSIG4
V-set and immunoglobulin domain-containing protein 4

3

1

High-throughput

0.609

High

1199810

AGK
Acylglycerol kinase, mitochondrial

2

0

High-throughput

0.602

High

1364947

KLK5
Kallikrein-5

3

2

High-throughput

0.593

High

1191602

RABL6
Rab-like protein 6

2

1

High-throughput

0.574

High

1293791

FBX11
F-box only protein 11

2

1

High-throughput

0.574

High

1324669

MUC20
Mucin-20

2

3

High-throughput

0.574

High

1364934

RN167
E3 ubiquitin-protein ligase RNF167

2

4

High-throughput

0.574

High

1364945

E41L3
Band 4.1-like protein 3

2

7

High-throughput

0.574

High

1143076

KPCD1
Serine/threonine-protein kinase D1

2

1

High-throughput

0.571

High

1333586

SIDT2
SID1 transmembrane family member 2

2

1

High-throughput

0.549

High

1364930

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.536

High

1364939

PKHJ1
Pleckstrin homology domain-containing family J member 1

1

6

High-throughput

0.536

High

1364942

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

8

High-throughput

0.536

High

1364944

FND3A
Fibronectin type-III domain-containing protein 3A

1

1

High-throughput

0.536

High

436708

KPCB
Protein kinase C beta type

2

2

High-throughput

0.521

High

531118

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

4

High-throughput

0.521

High

908219

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

7

High-throughput

0.521

High

1051279

KPCZ
Protein kinase C zeta type

2

3

High-throughput

0.521

High

1327772

SH2D3
SH2 domain-containing protein 3C

2

14

High-throughput

0.521

High

471554

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.513

High

829910

PMEL
Melanocyte protein PMEL

1

0

High-throughput

0.513

High

772511

IRS1
Insulin receptor substrate 1

1

2

Small-scale

0.501

High

1364925

RUFY1
RUN and FYVE domain-containing protein 1

1

7

Small-scale

0.501

High

130191

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.489

High

427918

ICAM1
Intercellular adhesion molecule 1

1

2

High-throughput

0.489

High

484604

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

3

High-throughput

0.489

High

902871

BLK
Tyrosine-protein kinase Blk

1

5

High-throughput

0.489

High

1128656

ZN460
Zinc finger protein 460

1

1

High-throughput

0.489

High

1136298

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.489

High

1142122

P2RY6
P2Y purinoceptor 6

1

4

High-throughput

0.489

High

1293879

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

1

High-throughput

0.489

High

1325065

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

2

High-throughput

0.489

High

1326014

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.489

High

1340734

TPC2
Two pore channel protein 2

1

3

High-throughput

0.489

High

1364928

NUAK2
NUAK family SNF1-like kinase 2

1

1

High-throughput

0.489

High

1364933

WDR55
WD repeat-containing protein 55

1

1

High-throughput

0.489

High

1364937

CHODL
Chondrolectin

1

2

High-throughput

0.489

High

1364948

PCDBF
Protocadherin beta-15

1

1

High-throughput

0.489

High

173148

XPO1
Exportin-1

1

15

High-throughput

0.479

High

242456

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

363649

EGFR
Epidermal growth factor receptor

1

15

High-throughput

0.479

High

562275

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

612273

ARF4
ADP-ribosylation factor 4

1

10

High-throughput

0.479

High

720286

UFO
Tyrosine-protein kinase receptor UFO

1

13

High-throughput

0.479

High

942783

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

High-throughput

0.479

High

958804

ARF3
ADP-ribosylation factor 3

1

10

High-throughput

0.479

High

975156

ARF6
ADP-ribosylation factor 6

1

10

High-throughput

0.479

High

1015080

ARF5
ADP-ribosylation factor 5

1

10

High-throughput

0.479

High

1138450

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1276254

ATG9A
Autophagy-related protein 9A

1

7

High-throughput

0.479

High

1313774

S15A3
Solute carrier family 15 member 3

1

2

High-throughput

0.479

High

1364921

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.479

High

1364941

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1120480

SCRB2
Lysosome membrane protein 2

1

2

Small-scale

0.457

High

530144

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

934929

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.445

High

1335361

CAMKV
CaM kinase-like vesicle-associated protein

1

1

High-throughput

0.445

High

315826

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.437

High

323506

TRI37
E3 ubiquitin-protein ligase TRIM37

1

7

High-throughput

0.437

High

346131

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.437

High

348177

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

6

High-throughput

0.437

High

372714

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

440162

LCK
Tyrosine-protein kinase Lck

1

5

High-throughput

0.437

High

589292

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

642997

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.437

High

696080

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

703967

DUS1
Dual specificity protein phosphatase 1

1

7

High-throughput

0.437

High

768776

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

777734

VGFR3
Vascular endothelial growth factor receptor 3

1

5

High-throughput

0.437

High

879315

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.437

High

970857

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.437

High

1004907

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.437

High

1052843

DUSP2
Dual specificity protein phosphatase 2

1

7

High-throughput

0.437

High

1095039

DUS4
Dual specificity protein phosphatase 4

1

7

High-throughput

0.437

High

1096773

RFA4
Replication protein A 30 kDa subunit

1

6

High-throughput

0.437

High

1100179

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.437

High

1161874

DUS5
Dual specificity protein phosphatase 5

1

7

High-throughput

0.437

High

1162455

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.437

High

1163856

DUS6
Dual specificity protein phosphatase 6

1

8

High-throughput

0.437

High

1227173

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.437

High

1229594

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

1233390

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.437

High

1254868

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1334707

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.437

High

1355896

DUS19
Dual specificity protein phosphatase 19

1

8

High-throughput

0.437

High

1364926

DUS23
Dual specificity protein phosphatase 23

1

10

High-throughput

0.437

High

1364932

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

1364935

ECT2
Protein ECT2

1

6

High-throughput

0.437

High

1364938

SP110
Sp110 nuclear body protein

1

5

High-throughput

0.437

High

1364949

SRPRB
Signal recognition particle receptor subunit beta

1

12

High-throughput

0.437

High

1333467

GOLM1
Golgi membrane protein 1

1

0

Small-scale

0.426

High

1364924

DIRC2
Solute carrier family 49 member 4

1

0

High-throughput

0.426

High

104194

F5H1C8
Solute carrier family 15 member 3

1

2

High-throughput

0.407

High

541045

PIM1
Serine/threonine-protein kinase pim-1

1

2

High-throughput

0.407

High

1054131

BTK
Tyrosine-protein kinase BTK

1

7

High-throughput

0.407

High

1220501

BTBD8
BTB/POZ domain-containing protein 8

1

1

High-throughput

0.407

High

1238885

MFS12
Major facilitator superfamily domain-containing protein 12

1

1

High-throughput

0.407

High

1316657

S38A6
Solute carrier family 38 member 6

1

1

High-throughput

0.407

High

1364923

AURKB
Aurora kinase B

1

2

High-throughput

0.407

High

1364931

E41L1
Band 4.1-like protein 1

1

8

High-throughput

0.407

High

351863

IGSF6
Immunoglobulin superfamily member 6

2

0

High-throughput

0.328

High

1100626

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

2

0

High-throughput

0.328

High

1364927

ZY11B
Protein zyg-11 homolog B

2

0

High-throughput

0.328

High

329956

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.279

Low

486597

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.279

Low

665649

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.279

Low

688088

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.279

Low

1239407

IIGP5
Interferon-inducible GTPase 5

1

0

High-throughput

0.279

Low

1364929

CSTL1
Cystatin-like 1

1

0

High-throughput

0.279

Low

354153

CLPT1
Putative lipid scramblase CLPTM1

1

0

High-throughput

0.269

Low

258316

TRI13
E3 ubiquitin-protein ligase TRIM13

1

0

High-throughput

0.249

Low

519180

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

1220699

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025