HitPredict

Interactor 1: RYK (P34925)
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Gene: RYK

Interactor 2: DSG2 (Q14126)
Desmoglein-2 (Cadherin family member 5) (HDGC)
Gene: DSG2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35384245, 21875946
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 607 Hs			1 1118
+	Hs
		507992 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		DSG2_HUMAN (1-1118): 0: 1174: 100.00
+	Hs
		1048593 NTRK3_HUMAN (61-607): 7.76e-137: 420: 21.92		DSG2_HUMAN (1-1118): 0: 1174: 100.00
+	Hs
		601509 FGFR2_HUMAN (139-601): 5.39e-134: 413: 26.40		DSG2_HUMAN (1-1118): 0: 1174: 100.00
+	Hs
		713831 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		DSG4_HUMAN (3-1052): 0: 912: 35.14
+	Hs
		507929 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		CAD11_HUMAN (9-848): 0: 645: 22.22
+	Hs
		507817 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		CADH1_HUMAN (22-670): 0: 577: 31.67
+	Hs
		713894 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDB2_HUMAN (55-599): 1.62e-93: 318: 18.79
+	Hs
		508294 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		PCDB7_HUMAN (54-599): 4.83e-92: 314: 19.42
+	Xl
		292719 FGFR1_XENLA (137-601): 2.66e-139: 426: 26.10		O93264_XENLA (1-493): 2.12e-78: 276: 18.63
+	Hs
		507842 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		580205 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		713896 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDGH_HUMAN (1-387): 8.41e-62: 230: 20.45
+	Hs
		580237 NTRK3_HUMAN (61-607): 7.76e-137: 420: 21.92		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		384238 NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65		CADH2_HUMAN (1-489): 2.19e-63: 234: 18.52
+	Hs
		713786 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		DSC2_HUMAN (28-494): 8.1e-51: 196: 16.90
+	Hs
		971016 NTRK2_HUMAN (36-607): 8.19e-131: 404: 22.24		DSC2_HUMAN (28-494): 8.1e-51: 196: 16.90
+	Hs
		508000 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		DSC3_HUMAN (28-361): 8.23e-29: 126: 16.86
+	Hs
		713804 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		DSC3_HUMAN (28-361): 8.23e-29: 126: 16.86
+	Hs
		1055826 NTRK3_HUMAN (61-607): 7.76e-137: 420: 21.92		DSC3_HUMAN (28-361): 8.23e-29: 126: 16.86
+	Hs
		384674 NTRK1_HUMAN (122-607): 2.22e-129: 400: 25.65		DSG1_HUMAN (282-605): 2.58e-28: 125: 13.60