HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	12684064, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 840 Hs			1 776
+	Hs
		714219 HSP74_HUMAN (1-840): 0: 993: 100.00		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		320851 HS74L_HUMAN (1-840): 0: 959: 63.21		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		1042179 HS105_HUMAN (1-840): 0: 938: 62.95		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		714344 HSP74_HUMAN (1-840): 0: 993: 100.00		CUL5_HUMAN (2-776): 0: 622: 28.85
+	Hs
		504040 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		713963 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		564073 HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		504043 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		713966 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		504044 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		713967 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		504042 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		713965 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		504041 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Hs
		713964 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Hs
		504518 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		CUL5_HUMAN (2-776): 0: 622: 28.85
+	Hs
		714040 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		CUL5_HUMAN (2-776): 0: 622: 28.85