HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: BAG1 (Q99933)
BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1)
Gene: BAG1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.975

Property	Details
Experiments	19229298, 9305631, 34428256, 15603737, 10671488, 12874020, 11520069, 20156966, 11231577, 19931284
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	BAG~HSP70
Common GO terms	GO:0000774 - adenyl-nucleotide exchange factor activity GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 840 Hs			1 345
+	Rn
		69521 HSP74_RAT (1-840): 0: 979: 95.83		BAG1_RAT (1-345): 0: 518: 69.83
+	Rn
		69526 HSP7C_RAT (564-692): 1.76e-19: 95.5: 16.15		BAG1_RAT (1-345): 0: 518: 69.83
+	Mm
		571857 HS71B_MOUSE (571-686): 9.97e-18: 89.7: 23.08		BAG1_MOUSE (1-345): 0: 520: 71.27
+	Hs
		504647 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		BAG1_HUMAN (1-345): 4.2e-176: 493: 100.00
+	Hs
		714058 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		BAG1_HUMAN (1-345): 4.2e-176: 493: 100.00
+	Hs
		564166 HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86		BAG1_HUMAN (1-345): 4.2e-176: 493: 100.00
+	Hs
		1120588 Q53FC7_HUMAN (587-690): 3.01e-16: 85.1: 22.86		BAG1_HUMAN (1-345): 4.2e-176: 493: 100.00