HitPredict

Interactor 1: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36413948
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Hs			1 2414
+	Hs
		717754 BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		584938 RO52_HUMAN (33-392): 4.67e-43: 158: 13.14		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		749421 BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		631409 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20
+	Mm
		1246861 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		BRD8_MOUSE (442-1175): 6.73e-37: 154: 14.71
+	Hs
		987995 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		KMT2C_HUMAN (416-1078): 1.02e-10: 70.1: 11.13
+	Hs
		718227 BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16		BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31
+	Hs
		1262804 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86
+	Hs
		585104 RO52_HUMAN (33-392): 4.67e-43: 158: 13.14		NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89
+	Hs
		750002 BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63		NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89
+	Hs
		749959 BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Hs
		554277 BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16		MUC1_HUMAN (1949-2412): 4.52e-13: 77.5: 9.23
+	Hs
		718068 BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Mm
		101543 RN138_MOUSE (31-190): 1.32e-45: 159: 18.68		F8VQD1_MOUSE (1081-1354): 5.61e-11: 70.6: 17.92
+	Hs
		1056954 BARD1_HUMAN (4-335): 2.56e-39: 151: 13.35		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		749430 BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63		BPTF_HUMAN (2011-2413): 1.11e-14: 82.9: 12.86
+	Hs
		1056961 PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		749499 BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		1108526 PCGF3_HUMAN (34-224): 6.2e-39: 141: 17.53		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		749734 BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25