HitPredict

Interactor 1: CRFR1 (P34998)
Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1)
Gene: CRHR1

Interactor 2: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10598591
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_2~G-alpha
Common GO terms	GO:0005886 - plasma membrane GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007190 - activation of adenylate cyclase activity GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 415 Hs			1 394
+	Hs
		391340 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		714730 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09
+	Hs
		450978 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		GNAO_HUMAN (1-394): 2.43e-153: 438: 40.66
+	Hs
		714727 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		GNAQ_HUMAN (11-394): 9.45e-151: 432: 38.02
+	Hs
		793723 GLP1R_HUMAN (2-413): 1.37e-95: 295: 27.52		GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00
+	Hs
		686282 VIPR1_HUMAN (19-409): 1.76e-94: 292: 27.86		GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00
+	Hs
		677567 CALCR_HUMAN (37-397): 3.04e-90: 282: 30.00		GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00
+	Hs
		926674 PTH1R_HUMAN (41-411): 1.43e-98: 307: 29.66		GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09
+	Hs
		686272 VIPR1_HUMAN (19-409): 1.76e-94: 292: 27.86		GNAQ_HUMAN (11-394): 9.45e-151: 432: 38.02