HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.994

The method score is based on:

Property Details
Experiments 16714294, 24457600, 25843776, 26151332, 26468281, 27647897, 27705803, 29402932, 24981860, 33961781, 16359901, 35390228, 34316702, 37014752, 17157253, 19636380, 16751658, 22325352, 21676867, 25355358 and 14 others

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Identification Methods biochemical, pull down, affinity chromatography technology, x-ray crystallography, two hybrid, enzymatic study, anti bait coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid and 3 others

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Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains RAWUL~RAWUL, zf-C3HC4_2~zf-C3HC4_2
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000151 - ubiquitin ligase complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006338 - chromatin remodeling
and 5 others

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Homologous interactions 19

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024