HitPredict

Interactor 1: CCND3 (P30281)
G1/S-specific cyclin-D3
Gene: CCND3

Interactor 2: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17274640
Identification Methods	affinity chromatography technology, antibody array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding and 1 others more... GO:0051301 - cell division
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 292 Hs			1 327
+	Hs
		664702 CCND1_HUMAN (2-292): 1.66e-100: 298: 51.86		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		573789 CCNB1_HUMAN (10-285): 8.26e-89: 272: 23.02		PP1B_HUMAN (1-327): 0: 597: 100.00
+	Hs
		664655 CCND1_HUMAN (2-292): 1.66e-100: 298: 51.86		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		967663 CCNA1_HUMAN (4-283): 4.46e-93: 284: 25.89		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Mm
		666788 CCNB1_MOUSE (8-285): 1.04e-84: 262: 21.58		PP1B_MOUSE (1-327): 0: 597: 100.00
+	Mm
		718924 CCND3_MOUSE (1-292): 1.71e-86: 262: 94.52		PP1B_MOUSE (1-327): 0: 597: 100.00
+	Mm
		968111 CCNA1_MOUSE (7-284): 1.94e-90: 276: 25.00		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Hs
		573788 CCNB1_HUMAN (10-285): 8.26e-89: 272: 23.02		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		718876 CCND3_HUMAN (1-292): 8.64e-89: 267: 100.00		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		573765 CCNB1_HUMAN (10-285): 8.26e-89: 272: 23.02		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Mm
		666787 CCNB1_MOUSE (8-285): 1.04e-84: 262: 21.58		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Mm
		718923 CCND3_MOUSE (1-292): 1.71e-86: 262: 94.52		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Hs
		718867 CCND3_HUMAN (1-292): 8.64e-89: 267: 100.00		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Mm
		666789 CCNB1_MOUSE (8-285): 1.04e-84: 262: 21.58		PP1G_MOUSE (1-327): 0: 569: 86.89
+	Mm
		718925 CCND3_MOUSE (1-292): 1.71e-86: 262: 94.52		PP1G_MOUSE (1-327): 0: 569: 86.89
+	Mm
		671886 CCND1_MOUSE (2-292): 1.73e-85: 259: 51.86		PP1G_MOUSE (1-327): 0: 569: 86.89
+	Hs
		977460 CCNA1_HUMAN (4-283): 4.46e-93: 284: 25.89		PP2AB_HUMAN (8-303): 1.26e-176: 492: 46.13
+	Hs
		718799 CCND2_HUMAN (1-292): 1.55e-81: 249: 61.15		PP2AA_HUMAN (8-303): 2.78e-176: 491: 45.79