Protein: CCND3
G1/S-specific cyclin-D3

Gene: CCND3
Organism: Homo sapiens
Interactions: 80
UniProt ID: P30281

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

549068

CDK4
Cyclin-dependent kinase 4

28

20

Small-scale

0.993

High

718882

CDK6
Cyclin-dependent kinase 6

25

20

Small-scale

0.993

High

718868

CDN1A
Cyclin-dependent kinase inhibitor 1

20

20

Small-scale

0.991

High

718871

CDN1B
Cyclin-dependent kinase inhibitor 1B

12

20

Small-scale

0.981

High

718883

CDK5
Cyclin-dependent kinase 5

8

20

High-throughput

0.973

High

667569

CDK2
Cyclin-dependent kinase 2

9

20

Small-scale

0.972

High

443208

CDK1
Cyclin-dependent kinase 1

4

20

High-throughput

0.903

High

718873

CDN1C
Cyclin-dependent kinase inhibitor 1C

4

20

High-throughput

0.903

High

636045

CD11B
Cyclin-dependent kinase 11B

2

20

Small-scale

0.817

High

718881

CDK3
Cyclin-dependent kinase 3

2

20

High-throughput

0.783

High

718884

CDK16
Cyclin-dependent kinase 16

2

20

High-throughput

0.783

High

718885

CDK18
Cyclin-dependent kinase 18

2

20

High-throughput

0.783

High

322092

CDK14
Cyclin-dependent kinase 14

1

20

Small-scale

0.766

High

718886

RBL2
Retinoblastoma-like protein 2

5

20

Small-scale

0.723

High

718905

RPC7L
DNA-directed RNA polymerase III subunit RPC7-like

4

0

High-throughput

0.668

High

718870

CDN2C
Cyclin-dependent kinase 4 inhibitor C

3

12

High-throughput

0.667

High

718899

CBP
CREB-binding protein

3

9

High-throughput

0.667

High

718919

KLK5
Kallikrein-5

3

2

High-throughput

0.667

High

718865

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

High-throughput

0.653

High

442611

RB
Retinoblastoma-associated protein

3

20

Small-scale

0.647

High

711687

RABP2
Cellular retinoic acid-binding protein 2

3

0

Small-scale

0.646

High

543468

VDR
Vitamin D3 receptor

2

8

Small-scale

0.633

High

718917

ATF5
Cyclic AMP-dependent transcription factor ATF-5

2

1

Small-scale

0.633

High

718893

MK06
Mitogen-activated protein kinase 6

1

19

High-throughput

0.621

High

550870

PCNA
Proliferating cell nuclear antigen

2

7

Small-scale

0.619

High

718888

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.618

High

718900

DTBP1
Dysbindin

2

3

Small-scale

0.614

High

718914

EIF3K
Eukaryotic translation initiation factor 3 subunit K

2

0

Small-scale

0.614

High

718894

MCM10
Protein MCM10 homolog

2

1

High-throughput

0.611

High

169452

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

1

High-throughput

0.606

High

718875

CDN2D
Cyclin-dependent kinase 4 inhibitor D

2

12

High-throughput

0.606

High

718916

STAP1
Signal-transducing adaptor protein 1

2

0

High-throughput

0.602

High

718913

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.601

High

718895

CCD13
Coiled-coil domain-containing protein 13

2

0

High-throughput

0.580

High

718897

MNS1
Meiosis-specific nuclear structural protein 1

2

0

High-throughput

0.580

High

718912

CN119
Uncharacterized protein C14orf119

2

0

High-throughput

0.580

High

520521

RARA
Retinoic acid receptor alpha

1

4

Small-scale

0.573

High

718891

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

Small-scale

0.561

High

228971

AKAP8
A-kinase anchor protein 8

1

4

Small-scale

0.552

High

519338

MYB
Transcriptional activator Myb

1

5

High-throughput

0.541

High

674947

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.541

High

718918

AMOL2
Angiomotin-like protein 2

1

1

High-throughput

0.536

High

718874

ETV1
ETS translocation variant 1

1

0

High-throughput

0.518

High

718908

MAF1
Repressor of RNA polymerase III transcription MAF1 homolog

1

0

High-throughput

0.518

High

718867

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

18

High-throughput

0.515

High

718877

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

18

High-throughput

0.515

High

608224

EGLN
Endoglin

1

0

High-throughput

0.513

High

718890

VGLL4
Transcription cofactor vestigial-like protein 4

1

0

High-throughput

0.513

High

421567

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

702877

DPOD1
DNA polymerase delta catalytic subunit

1

6

Small-scale

0.501

High

718892

NCOA2
Nuclear receptor coactivator 2

1

5

Small-scale

0.501

High

351508

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

1

High-throughput

0.494

High

390276

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.481

High

584710

NDKA
Nucleoside diphosphate kinase A

1

1

High-throughput

0.481

High

718878

PRS4
26S proteasome regulatory subunit 4

1

4

High-throughput

0.481

High

718879

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

1

High-throughput

0.481

High

718889

FHL3
Four and a half LIM domains protein 3

1

1

High-throughput

0.481

High

718902

QKI
KH domain-containing RNA-binding protein QKI

1

1

High-throughput

0.481

High

718911

SHLB2
Endophilin-B2

1

1

High-throughput

0.481

High

240851

PRKN
E3 ubiquitin-protein ligase parkin

1

8

Small-scale

0.479

High

558959

LYL1
Protein lyl-1

1

4

High-throughput

0.479

High

568764

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

2

Small-scale

0.479

High

593026

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

High-throughput

0.479

High

718872

TSC2
Tuberin

1

5

Small-scale

0.479

High

718876

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

18

High-throughput

0.479

High

718880

RBX1
E3 ubiquitin-protein ligase RBX1

1

5

Small-scale

0.479

High

718907

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

8

Small-scale

0.479

High

718915

HERC5
E3 ISG15--protein ligase HERC5

1

5

Small-scale

0.479

High

718869

CASP2
Caspase-2

1

0

Small-scale

0.460

High

718901

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

0

High-throughput

0.460

High

718903

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.460

High

533600

CLUS
Clusterin

1

0

High-throughput

0.458

High

718898

FBH1
F-box DNA helicase 1

1

0

Small-scale

0.458

High

718904

ZNF2
Zinc finger protein 2

1

0

High-throughput

0.458

High

718910

NPDC1
Neural proliferation differentiation and control protein 1

1

2

Small-scale

0.457

High

718887

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.457

High

718896

TEX11
Testis-expressed protein 11

1

1

High-throughput

0.439

High

718906

KIFC3
Kinesin-like protein KIFC3

2

0

High-throughput

0.316

High

718866

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.282

High

718909

SIL1
Nucleotide exchange factor SIL1

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025