HitPredict

Interactor 1: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: H15 (P43276)
Histone H1.5 (H1 VAR.5) (H1b)
Gene: H1-5

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16627785
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Mm			1 223
+	Rn
		441596 Q6P751_RAT (3-301): 4.14e-145: 411: 43.23		H1T_RAT (1-206): 9.89e-33: 119: 50.48
+	Hs
		595685 CDK2_HUMAN (3-301): 1.28e-145: 412: 43.56		H13_HUMAN (1-181): 1.41e-24: 98.6: 65.93
+	Rn
		93227 Q6P751_RAT (3-301): 4.14e-145: 411: 43.23		H11_RAT (1-120): 2.25e-19: 84.4: 68.85
+	Hs
		595319 CDK2_HUMAN (3-301): 1.28e-145: 412: 43.56		H15_HUMAN (1-115): 9.38e-18: 80.5: 87.29
+	Mm
		847025 CDK2_MOUSE (3-301): 2.58e-136: 391: 37.32		H15_MOUSE (1-202): 7.33e-24: 96.7: 100.00
+	Hs
		667793 CDK2_HUMAN (3-301): 1.28e-145: 412: 43.56		H11_HUMAN (38-181): 6.75e-16: 75.1: 63.89
+	Hs
		443158 CDK1_HUMAN (3-300): 2.26e-130: 374: 42.24		H13_HUMAN (1-181): 1.41e-24: 98.6: 65.93
+	Hs
		549043 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		H13_HUMAN (1-181): 1.41e-24: 98.6: 65.93
+	Mm
		586400 CDK2_MOUSE (3-301): 2.58e-136: 391: 37.32		H12_MOUSE (1-115): 6.5e-15: 72.4: 82.61
+	Mm
		847012 CDK2_MOUSE (3-301): 2.58e-136: 391: 37.32		H11_MOUSE (1-121): 8.8e-15: 72: 69.11
+	Rn
		93223 CDK1_RAT (3-300): 3.66e-130: 373: 42.24		H11_RAT (1-120): 2.25e-19: 84.4: 68.85
+	Hs
		443157 CDK1_HUMAN (3-300): 2.26e-130: 374: 42.24		H15_HUMAN (1-115): 9.38e-18: 80.5: 87.29
+	Hs
		443318 CDK1_HUMAN (3-300): 2.26e-130: 374: 42.24		H11_HUMAN (38-181): 6.75e-16: 75.1: 63.89
+	Hs
		1025326 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		H11_HUMAN (38-181): 6.75e-16: 75.1: 63.89
+	Mm
		847019 CDK6_MOUSE (5-303): 4.51e-129: 372: 67.67		H11_MOUSE (1-121): 8.8e-15: 72: 69.11
+	Mm
		543004 CDK1_MOUSE (3-300): 2.8e-129: 371: 42.24		H12_MOUSE (1-115): 6.5e-15: 72.4: 82.61
+	Hs
		549123 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		H11_HUMAN (38-181): 6.75e-16: 75.1: 63.89
+	Mm
		543016 CDK1_MOUSE (3-300): 2.8e-129: 371: 42.24		H11_MOUSE (1-121): 8.8e-15: 72: 69.11
+	Mm
		586398 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		H12_MOUSE (1-115): 6.5e-15: 72.4: 82.61
+	Mm
		718966 CDK4_MOUSE (1-303): 3.21e-128: 368: 100.00		H11_MOUSE (1-121): 8.8e-15: 72: 69.11