HitPredict

Interactor 1: MPIP2 (P30305)
M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)
Gene: CDC25B

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.758

Property	Details
Experiments	26496610, 27432908, 28514442, 10713667, 33961781, 35271311, 15629715, 16672277, 12764136, 12766774
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 580 Hs			1 245
+	Rn
		878194 MPIP2_RAT (1-580): 0: 830: 79.66		1433E_RAT (2-241): 9.95e-144: 403: 68.18
+	Hs
		719205 MPIP2_HUMAN (1-580): 0: 823: 100.00		1433E_HUMAN (2-241): 9.95e-144: 403: 68.18
+	Hs
		690759 MPIP2_HUMAN (1-580): 0: 823: 100.00		1433T_HUMAN (1-245): 2.61e-140: 395: 79.59
+	Hs
		719194 MPIP2_HUMAN (1-580): 0: 823: 100.00		1433B_HUMAN (1-242): 9.05e-140: 393: 87.60
+	Mm
		719288 MPIP2_MOUSE (1-580): 0: 833: 80.90		1433B_MOUSE (1-242): 3.79e-128: 364: 87.19
+	Hs
		719204 MPIP2_HUMAN (1-580): 0: 823: 100.00		1433G_HUMAN (1-240): 2.38e-108: 314: 74.59
+	Hs
		719213 MPIP2_HUMAN (1-580): 0: 823: 100.00		1433F_HUMAN (2-240): 1.27e-107: 312: 74.49
+	Hs
		719195 MPIP2_HUMAN (1-580): 0: 823: 100.00		1433S_HUMAN (1-237): 8.31e-104: 302: 71.97
+	Hs
		719124 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		719123 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433E_HUMAN (2-241): 9.95e-144: 403: 68.18
+	Hs
		690758 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433T_HUMAN (1-245): 2.61e-140: 395: 79.59
+	Hs
		719107 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433B_HUMAN (1-242): 9.05e-140: 393: 87.60
+	Rn
		878192 MPIP1_RAT (45-578): 0: 618: 42.59		1433E_RAT (2-241): 9.95e-144: 403: 68.18
+	Hs
		719122 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433G_HUMAN (1-240): 2.38e-108: 314: 74.59
+	Hs
		719132 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433F_HUMAN (2-240): 1.27e-107: 312: 74.49
+	Hs
		719108 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433S_HUMAN (1-237): 8.31e-104: 302: 71.97
+	Xl
		237422 MPIP2_XENLA (49-577): 0: 536: 35.53		O57468_XENLA (2-241): 8.81e-143: 401: 68.18
+	Hs
		690760 MPIP3_HUMAN (160-577): 3e-146: 432: 35.10		1433T_HUMAN (1-245): 2.61e-140: 395: 79.59
+	Hs
		719290 MPIP3_HUMAN (160-577): 3e-146: 432: 35.10		1433B_HUMAN (1-242): 9.05e-140: 393: 87.60
+	Hs
		719291 MPIP3_HUMAN (160-577): 3e-146: 432: 35.10		1433S_HUMAN (1-237): 8.31e-104: 302: 71.97