HitPredict

Interactor 1: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Interactor 2: DDR1 (Q08345)
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Gene: DDR1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	22057045
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 913
+	Hs
		547024 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		DDR1_HUMAN (1-913): 0: 911: 100.00
+	Hs
		507884 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		607900 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87
+	Hs
		609192 RADI_HUMAN (19-595): 5.41e-151: 448: 45.47		FGFR3_HUMAN (551-905): 1.32e-110: 360: 32.16
+	Hs
		507828 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		507885 RADI_HUMAN (19-595): 5.41e-151: 448: 45.47		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		546928 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87
+	Hs
		607901 RADI_HUMAN (19-595): 5.41e-151: 448: 45.47		FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87
+	Hs
		507865 MOES_HUMAN (19-595): 5.97e-146: 435: 44.44		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		433240 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		YES_HUMAN (563-907): 1.25e-105: 339: 31.59
+	Hs
		607883 MOES_HUMAN (19-595): 5.97e-146: 435: 44.44		FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87
+	Hs
		719502 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		NTRK3_HUMAN (607-905): 4.06e-67: 242: 43.63
+	Hs
		435559 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22
+	Hs
		384207 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		719722 RADI_HUMAN (19-595): 5.41e-151: 448: 45.47		NTRK3_HUMAN (607-905): 4.06e-67: 242: 43.63
+	Hs
		384378 RADI_HUMAN (19-595): 5.41e-151: 448: 45.47		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Dm
		448235 MOEH_DROME (17-595): 4.74e-153: 453: 43.79		INSR_DROME (616-912): 1.91e-52: 202: 38.03
+	Hs
		385554 E41L5_HUMAN (2-595): 6.77e-134: 410: 18.38		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		719701 RADI_HUMAN (19-595): 5.41e-151: 448: 45.47		ROR2_HUMAN (608-905): 1.57e-50: 194: 38.26
+	Hs
		435541 MOES_HUMAN (19-595): 5.97e-146: 435: 44.44		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22