HitPredict

Interactor 1: CD22 (P35329)
B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)
Gene: CD22

Interactor 2: TLR1 (Q9EPQ1)
Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
Gene: TLR1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ig_3~LRR_8
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 868 Mm			1 795
+	Mm
		722907 CD22_MOUSE (1-868): 0: 595: 100.00		TLR6_MOUSE (16-793): 4.41e-116: 371: 65.55
+	Mm
		722910 CD22_MOUSE (1-868): 0: 595: 100.00		TLR2_MOUSE (4-781): 3.13e-100: 329: 28.43
+	Hs
		590613 CD22_HUMAN (19-868): 1.88e-168: 512: 58.73		TLR10_HUMAN (5-788): 6.53e-105: 342: 46.82
+	Mm
		722899 CD22_MOUSE (1-868): 0: 595: 100.00		TLR7_MOUSE (29-583): 8.71e-30: 128: 13.61
+	Mm
		722909 CD22_MOUSE (1-868): 0: 595: 100.00		TLR5_MOUSE (4-312): 1.89e-14: 79.6: 13.91
+	Mm
		1143686 SN_MOUSE (17-749): 2.14e-65: 241: 17.22		TLR1_MOUSE (1-795): 1.38e-128: 404: 100.00
+	Hs
		237425 CD22_HUMAN (19-868): 1.88e-168: 512: 58.73		TLR5_HUMAN (4-238): 2.74e-16: 85.4: 14.77
+	Hs
		1073329 SIG10_HUMAN (314-867): 8.2e-36: 147: 19.50		TLR1_HUMAN (4-788): 2.87e-126: 398: 73.89
+	Mm
		1265315 SIGL5_MOUSE (264-590): 1.34e-18: 92.2: 17.20		TLR1_MOUSE (1-795): 1.38e-128: 404: 100.00
+	Mm
		1265318 SIGL5_MOUSE (264-590): 1.34e-18: 92.2: 17.20		TLR2_MOUSE (4-781): 3.13e-100: 329: 28.43
+	Hs
		237434 SIG11_HUMAN (395-771): 2.98e-41: 163: 22.38		TLR5_HUMAN (4-238): 2.74e-16: 85.4: 14.77
+	Hs
		179956 SIG11_HUMAN (395-771): 2.98e-41: 163: 22.38		TLR3_HUMAN (260-561): 8.69e-15: 80.8: 12.58
+	Hs
		120171 SIG11_HUMAN (395-771): 2.98e-41: 163: 22.38		TLR4_HUMAN (1-440): 1.1e-14: 80.4: 12.36
+	Hs
		179954 SIG10_HUMAN (314-867): 8.2e-36: 147: 19.50		TLR3_HUMAN (260-561): 8.69e-15: 80.8: 12.58
+	Hs
		1297092 SIG10_HUMAN (314-867): 8.2e-36: 147: 19.50		TLR8_HUMAN (261-554): 1.7e-12: 73.4: 13.17
+	Mm
		1265316 SIGL5_MOUSE (264-590): 1.34e-18: 92.2: 17.20		TLR5_MOUSE (4-312): 1.89e-14: 79.6: 13.91
+	Mm
		1265317 SIGL5_MOUSE (264-590): 1.34e-18: 92.2: 17.20		TLR4_MOUSE (227-522): 1.37e-09: 63.8: 12.16