HitPredict

Interactor 1: SOX5 (P35711)
Transcription factor SOX-5
Gene: SOX5

Interactor 2: SOX11 (P35716)
Transcription factor SOX-11
Gene: SOX11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box
Common GO terms	GO:0000785 - chromatin GO:0000976 - transcription cis-regulatory region binding GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003700 - DNA-binding transcription factor activity and 1 others more... GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 763 Hs			1 441
+	Hs
		727788 SOX5_HUMAN (1-763): 0: 611: 100.00		CIC_HUMAN (13-286): 4.76e-43: 164: 21.90
+	Hs
		727709 SOX5_HUMAN (1-763): 0: 611: 100.00		SOX2_HUMAN (22-330): 6.16e-46: 163: 23.95
+	Hs
		133759 SOX5_HUMAN (1-763): 0: 611: 100.00		SOX1_HUMAN (43-122): 9.21e-40: 148: 60.00
+	Hs
		727705 SOX5_HUMAN (1-763): 0: 611: 100.00		SOX6_HUMAN (5-252): 2.44e-34: 137: 25.98
+	Hs
		727795 SOX5_HUMAN (1-763): 0: 611: 100.00		SOX7_HUMAN (21-308): 3.43e-34: 133: 25.42
+	Hs
		727827 SOX5_HUMAN (1-763): 0: 611: 100.00		SOX13_HUMAN (24-226): 1.8e-32: 131: 29.56
+	Mm
		727702 SOX5_MOUSE (1-763): 0: 609: 96.86		SOX6_MOUSE (5-252): 2.99e-32: 131: 25.59
+	Hs
		727704 SOX5_HUMAN (1-763): 0: 611: 100.00		SOX5_HUMAN (2-215): 2.51e-30: 125: 25.70
+	Mm
		1103190 Q2TBA9_MOUSE (1-763): 0: 550: 87.70		Q60I23_MOUSE (17-330): 1.96e-45: 162: 23.89
+	Hs
		727910 SOX6_HUMAN (14-763): 6.99e-144: 444: 56.44		CIC_HUMAN (13-286): 4.76e-43: 164: 21.90
+	Hs
		727836 SOX6_HUMAN (14-763): 6.99e-144: 444: 56.44		SOX2_HUMAN (22-330): 6.16e-46: 163: 23.95
+	Hs
		727941 SOX6_HUMAN (14-763): 6.99e-144: 444: 56.44		SOX13_HUMAN (24-226): 1.8e-32: 131: 29.56
+	Hs
		727966 SOX13_HUMAN (107-730): 3.41e-75: 257: 42.52		SOX11_HUMAN (1-441): 4.81e-97: 300: 100.00
+	Dm
		1212946 PANG2_DROME (63-630): 4.71e-101: 339: 15.64		PANG2_DROME (25-309): 5.75e-38: 149: 17.97
+	Dm
		1212959 PANG2_DROME (63-630): 4.71e-101: 339: 15.64		Q9VUD3_DROME (38-213): 3.21e-31: 127: 35.17
+	Hs
		1357429 SOX13_HUMAN (107-730): 3.41e-75: 257: 42.52		SOX13_HUMAN (24-226): 1.8e-32: 131: 29.56