HitPredict

Interactor 1: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Interactor 2: PGBM (P98160)
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide]
Gene: HSPG2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 1.00 0.831

The method score is based on:

Property Details
Experiments 21596751, 23374253
Identification Methods far western blotting, pull down, enzyme linked immunosorbent assay, anti bait coimmunoprecipitation, solid phase assay, filter binding
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains I-set~I-set, I-set~Ig_2, Ig_3~I-set, ig~I-set, Ig_2~ig, Ig_3~ig, Ig_2~Ig_2, Ig_2~Ig_3, Ig_2~Laminin_G_1
Common GO terms GO:0001525 - angiogenesis
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 1356
Hs

1 4391
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024