Protein: BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3)

Gene: BIG3, ARFGEF3
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q5TH69

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005794 - Golgi apparatus
GO:0030658 - transport vesicle membrane
GO:0032012 - regulation of ARF protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

551404

SIAT1
Beta-galactoside alpha-2,6-sialyltransferase 1

2

1

High-throughput

0.628

High

1136951

PHB2
Prohibitin-2

4

1

Small-scale

0.626

High

912949

ARF6
ADP-ribosylation factor 6

1

16

High-throughput

0.618

High

686308

VIPR1
Vasoactive intestinal polypeptide receptor 1

2

2

High-throughput

0.574

High

824709

NPY2R
Neuropeptide Y receptor type 2

2

3

High-throughput

0.574

High

1136946

SIGL1
SIGLEC family-like protein 1

2

2

High-throughput

0.574

High

1136952

LPAR4
Lysophosphatidic acid receptor 4

2

9

High-throughput

0.574

High

1136957

PACC1
Proton-activated chloride channel

2

1

High-throughput

0.574

High

1136963

CLC2D
C-type lectin domain family 2 member D

2

5

High-throughput

0.574

High

1136944

PNKD
Probable hydrolase PNKD

2

1

High-throughput

0.558

High

1136959

ARL8B
ADP-ribosylation factor-like protein 8B

1

20

High-throughput

0.553

High

905961

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

2

Small-scale

0.543

High

845529

RAB9A
Ras-related protein Rab-9A

2

19

High-throughput

0.533

High

568699

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

Small-scale

0.512

High

126602

P2Y10
Putative P2Y purinoceptor 10

1

13

High-throughput

0.489

High

172032

GP182
G-protein coupled receptor 182

1

12

High-throughput

0.489

High

598957

FPR1
fMet-Leu-Phe receptor

1

9

High-throughput

0.489

High

639594

TNR5
Tumor necrosis factor receptor superfamily member 5

1

5

High-throughput

0.489

High

666312

NK3R
Neuromedin-K receptor

1

3

High-throughput

0.489

High

1030949

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

10

High-throughput

0.489

High

1136947

ARRD4
Arrestin domain-containing protein 4

1

13

High-throughput

0.489

High

1136954

KLK15
Kallikrein-15

1

3

High-throughput

0.489

High

1136967

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.489

High

1136968

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

4

High-throughput

0.489

High

1136969

NPTN
Neuroplastin

1

8

High-throughput

0.489

High

269000

CSDE1
Cold shock domain-containing protein E1

1

1

High-throughput

0.479

High

592305

RAB5A
Ras-related protein Rab-5A

1

10

High-throughput

0.479

High

844564

RAB5C
Ras-related protein Rab-5C

1

9

High-throughput

0.479

High

844982

RAB7A
Ras-related protein Rab-7a

1

16

High-throughput

0.479

High

895121

RAB2A
Ras-related protein Rab-2A

1

10

High-throughput

0.479

High

1041762

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1136939

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

1136943

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1136949

GOGA1
Golgin subfamily A member 1

1

2

High-throughput

0.479

High

1136953

VP33B
Vacuolar protein sorting-associated protein 33B

1

4

High-throughput

0.479

High

942721

SRPK2
SRSF protein kinase 2

1

4

High-throughput

0.457

High

178585

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

302533

CE152
Centrosomal protein of 152 kDa

1

1

High-throughput

0.437

High

338541

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.437

High

435666

IGF1R
Insulin-like growth factor 1 receptor

1

5

Small-scale

0.437

High

527513

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.437

High

564563

RHOQ
Rho-related GTP-binding protein RhoQ

1

15

High-throughput

0.437

High

566411

KPCA
Protein kinase C alpha type

1

1

Small-scale

0.437

High

651415

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

717919

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.437

High

835402

GSK3A
Glycogen synthase kinase-3 alpha

1

4

High-throughput

0.437

High

835813

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.437

High

840496

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.437

High

894113

CDC42
Cell division control protein 42 homolog

1

14

High-throughput

0.437

High

951067

RHOG
Rho-related GTP-binding protein RhoG

1

10

High-throughput

0.437

High

982112

1433F
14-3-3 protein eta

1

20

High-throughput

0.437

High

1026436

RFA4
Replication protein A 30 kDa subunit

1

3

High-throughput

0.437

High

1036649

SQSTM
Sequestosome-1

1

2

High-throughput

0.437

High

1070237

RAB35
Ras-related protein Rab-35

1

11

High-throughput

0.437

High

1136938

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

1136941

FBX42
F-box only protein 42

1

2

High-throughput

0.437

High

1136942

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1136945

NIN
Ninein

1

3

High-throughput

0.437

High

1136948

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

1136950

RING2
E3 ubiquitin-protein ligase RING2

1

5

High-throughput

0.437

High

1136955

RHOJ
Rho-related GTP-binding protein RhoJ

1

15

High-throughput

0.437

High

1136956

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

1136958

SACA1
Sperm acrosome membrane-associated protein 1

1

2

High-throughput

0.437

High

1136960

ANFY1
Rabankyrin-5

1

4

High-throughput

0.437

High

1136961

ZO2
Tight junction protein ZO-2

1

7

High-throughput

0.437

High

1136962

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.437

High

1136965

LAMP3
Lysosome-associated membrane glycoprotein 3

1

7

High-throughput

0.437

High

454709

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.279

Low

519410

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

0

High-throughput

0.279

Low

1136964

AP4E1
AP-4 complex subunit epsilon-1

1

0

High-throughput

0.279

Low

1136966

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

High-throughput

0.279

Low

318981

CEP43
Centrosomal protein 43

1

0

High-throughput

0.249

Low

351810

PTHY
Parathyroid hormone

1

0

Small-scale

0.249

Low

525959

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.249

Low

1136940

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024