Protein: GRK5
G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5)

Gene: GRK5
Organism: Homo sapiens
Interactions: 174
UniProt ID: P34947

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004703 - G protein-coupled receptor kinase activity
GO:0005080 - protein kinase C binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

640493

TA2R
Thromboxane A2 receptor

1

20

Small-scale

0.710

High

683394

IKBA
NF-kappa-B inhibitor alpha

1

10

Small-scale

0.692

High

761962

GRK6
G protein-coupled receptor kinase 6

1

16

High-throughput

0.691

High

458298

ADRB2
Beta-2 adrenergic receptor

1

10

Small-scale

0.647

High

465754

OPSD
Rhodopsin

1

13

Small-scale

0.647

High

669218

NK1R
Substance-P receptor

1

10

Small-scale

0.647

High

761948

GRK5
G protein-coupled receptor kinase 5

1

15

Small-scale

0.647

High

762060

CABP1
Calcium-binding protein 1

1

2

Small-scale

0.647

High

348065

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

High-throughput

0.618

High

461202

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468120

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

539957

BCR
Breakpoint cluster region protein

1

4

High-throughput

0.618

High

620157

NUCL
Nucleolin

1

6

High-throughput

0.618

High

713746

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

9

High-throughput

0.618

High

719766

V2R
Vasopressin V2 receptor

1

11

Small-scale

0.618

High

720646

AGTR1
Type-1 angiotensin II receptor

1

13

Small-scale

0.618

High

728550

AKT2
RAC-beta serine/threonine-protein kinase

1

16

High-throughput

0.618

High

761949

RECO
Recoverin

1

6

Small-scale

0.618

High

761955

V1AR
Vasopressin V1a receptor

1

12

Small-scale

0.618

High

761986

SRSF1
Serine/arginine-rich splicing factor 1

1

11

High-throughput

0.618

High

761997

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

2

High-throughput

0.618

High

762000

KANK1
KN motif and ankyrin repeat domain-containing protein 1

1

5

High-throughput

0.618

High

762005

STK38
Serine/threonine-protein kinase 38

1

15

High-throughput

0.618

High

762006

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

3

High-throughput

0.618

High

762008

DDB1
DNA damage-binding protein 1

1

6

High-throughput

0.618

High

762009

CDC37
Hsp90 co-chaperone Cdc37

1

14

High-throughput

0.618

High

762012

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

5

High-throughput

0.618

High

762013

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.618

High

762019

THOC4
THO complex subunit 4

1

6

High-throughput

0.618

High

762020

LIPB1
Liprin-beta-1

1

12

High-throughput

0.618

High

762022

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

20

High-throughput

0.618

High

762026

ABCF1
ATP-binding cassette sub-family F member 1

1

2

High-throughput

0.618

High

762035

DCAF5
DDB1- and CUL4-associated factor 5

1

10

High-throughput

0.618

High

762039

SRPK1
SRSF protein kinase 1

1

14

High-throughput

0.618

High

762042

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

2

High-throughput

0.618

High

762048

WDR12
Ribosome biogenesis protein WDR12

1

8

High-throughput

0.618

High

761956

SYUA
Alpha-synuclein

2

15

Small-scale

0.594

High

762062

ANFY1
Rabankyrin-5

1

0

High-throughput

0.586

High

175603

SR140
U2 snRNP-associated SURP motif-containing protein

1

7

High-throughput

0.553

High

762015

WDR82
WD repeat-containing protein 82

1

9

High-throughput

0.553

High

762030

DDB2
DNA damage-binding protein 2

1

7

High-throughput

0.553

High

762066

AFF4
AF4/FMR2 family member 4

1

4

High-throughput

0.553

High

762073

TBL2
Transducin beta-like protein 2

1

10

High-throughput

0.553

High

762018

TARSH
Target of Nesh-SH3

1

0

High-throughput

0.517

High

302695

SYUG
Gamma-synuclein

1

15

Small-scale

0.501

High

761984

CAV1
Caveolin-1

1

3

Small-scale

0.501

High

762007

SYUB
Beta-synuclein

1

15

Small-scale

0.501

High

123608

MYO1C
Unconventional myosin-Ic

1

12

High-throughput

0.479

High

127892

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

3

High-throughput

0.479

High

131136

CLIC1
Chloride intracellular channel protein 1

1

1

High-throughput

0.479

High

207455

DHX15
ATP-dependent RNA helicase DHX15

1

4

High-throughput

0.479

High

273167

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

11

High-throughput

0.479

High

323669

AP2A2
AP-2 complex subunit alpha-2

1

4

High-throughput

0.479

High

344635

AP2A1
AP-2 complex subunit alpha-1

1

4

High-throughput

0.479

High

522806

COT1
COUP transcription factor 1

1

14

High-throughput

0.479

High

559236

XRCC5
X-ray repair cross-complementing protein 5

1

3

High-throughput

0.479

High

565793

EF2
Elongation factor 2

1

2

High-throughput

0.479

High

577645

PLAK
Junction plakoglobin

1

4

High-throughput

0.479

High

612149

ARF4
ADP-ribosylation factor 4

1

2

High-throughput

0.479

High

659975

COF1
Cofilin-1

1

2

High-throughput

0.479

High

690772

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

697781

CALR
Calreticulin

1

2

High-throughput

0.479

High

698226

MAP4
Microtubule-associated protein 4

1

19

High-throughput

0.479

High

703273

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

2

High-throughput

0.479

High

724717

METK2
S-adenosylmethionine synthase isoform type-2

1

1

High-throughput

0.479

High

729641

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

761552

HSP74
Heat shock 70 kDa protein 4

1

12

High-throughput

0.479

High

761950

MYH9
Myosin-9

1

10

High-throughput

0.479

High

761951

MYH10
Myosin-10

1

10

High-throughput

0.479

High

761952

PRS7
26S proteasome regulatory subunit 7

1

9

High-throughput

0.479

High

761953

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.479

High

761957

IF4A3
Eukaryotic initiation factor 4A-III

1

11

High-throughput

0.479

High

761958

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

761959

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

6

High-throughput

0.479

High

761960

MTREX
Exosome RNA helicase MTR4

1

7

High-throughput

0.479

High

761963

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

3

High-throughput

0.479

High

761969

CSN2
COP9 signalosome complex subunit 2

1

3

High-throughput

0.479

High

761971

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

761972

PRS4
26S proteasome regulatory subunit 4

1

7

High-throughput

0.479

High

761973

PRS10
26S proteasome regulatory subunit 10B

1

8

High-throughput

0.479

High

761975

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

761976

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

3

High-throughput

0.479

High

761978

EF1A1
Elongation factor 1-alpha 1

1

2

High-throughput

0.479

High

761979

PRKDC
DNA-dependent protein kinase catalytic subunit

1

15

High-throughput

0.479

High

761980

ARF1
ADP-ribosylation factor 1

1

2

High-throughput

0.479

High

761981

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

8

High-throughput

0.479

High

761982

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

High-throughput

0.479

High

761983

OTUD4
OTU domain-containing protein 4

1

4

High-throughput

0.479

High

761985

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

761987

DHX9
ATP-dependent RNA helicase A

1

4

High-throughput

0.479

High

761989

TROP
Trophinin

1

7

High-throughput

0.479

High

761990

ILF3
Interleukin enhancer-binding factor 3

1

2

High-throughput

0.479

High

761991

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

High-throughput

0.479

High

761992

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

1

High-throughput

0.479

High

761993

TCOF
Treacle protein

1

5

High-throughput

0.479

High

761994

MYO9B
Unconventional myosin-IXb

1

9

High-throughput

0.479

High

761995

CUL4A
Cullin-4A

1

8

High-throughput

0.479

High

761996

CUL4B
Cullin-4B

1

8

High-throughput

0.479

High

761998

CKAP5
Cytoskeleton-associated protein 5

1

9

High-throughput

0.479

High

761999

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

12

High-throughput

0.479

High

762002

IMB1
Importin subunit beta-1

1

3

High-throughput

0.479

High

762003

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

7

High-throughput

0.479

High

762004

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

762010

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

3

High-throughput

0.479

High

762011

SPIN3
Spindlin-3

1

2

High-throughput

0.479

High

762014

LARP1
La-related protein 1

1

4

High-throughput

0.479

High

762016

DHX30
ATP-dependent RNA helicase DHX30

1

4

High-throughput

0.479

High

762017

MAEA
E3 ubiquitin-protein transferase MAEA

1

2

High-throughput

0.479

High

762024

SRRM1
Serine/arginine repetitive matrix protein 1

1

2

High-throughput

0.479

High

762025

DOCK4
Dedicator of cytokinesis protein 4

1

2

High-throughput

0.479

High

762029

MADD
MAP kinase-activating death domain protein

1

2

High-throughput

0.479

High

762033

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

7

High-throughput

0.479

High

762036

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

7

High-throughput

0.479

High

762037

FMNL2
Formin-like protein 2

1

1

High-throughput

0.479

High

762038

RANB9
Ran-binding protein 9

1

8

High-throughput

0.479

High

762041

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.479

High

762043

MBB1A
Myb-binding protein 1A

1

1

High-throughput

0.479

High

762045

CSN4
COP9 signalosome complex subunit 4

1

1

High-throughput

0.479

High

762046

RFIP5
Rab11 family-interacting protein 5

1

1

High-throughput

0.479

High

762047

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

5

High-throughput

0.479

High

762051

CWC22
Pre-mRNA-splicing factor CWC22 homolog

1

1

High-throughput

0.479

High

762052

DDX21
Nucleolar RNA helicase 2

1

12

High-throughput

0.479

High

762056

TOR4A
Torsin-4A

1

2

High-throughput

0.479

High

762057

KCTD5
BTB/POZ domain-containing protein KCTD5

1

7

High-throughput

0.479

High

762058

BCLF1
Bcl-2-associated transcription factor 1

1

2

High-throughput

0.479

High

762061

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

1

High-throughput

0.479

High

762063

HDAC6
Protein deacetylase HDAC6

1

8

High-throughput

0.479

High

762064

CSN7A
COP9 signalosome complex subunit 7a

1

1

High-throughput

0.479

High

762067

MRT4
mRNA turnover protein 4 homolog

1

1

High-throughput

0.479

High

762068

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

5

High-throughput

0.479

High

762069

SRRM2
Serine/arginine repetitive matrix protein 2

1

3

High-throughput

0.479

High

762070

RUVB1
RuvB-like 1

1

3

High-throughput

0.479

High

762072

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

5

High-throughput

0.479

High

762074

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

4

High-throughput

0.479

High

762075

SPIN1
Spindlin-1

1

2

High-throughput

0.479

High

134577

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

568613

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.458

High

761954

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.458

High

761968

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.458

High

761974

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.458

High

761977

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.458

High

761988

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.458

High

762001

BMS1
Ribosome biogenesis protein BMS1 homolog

1

0

High-throughput

0.458

High

762027

AATC2
Putative aspartate aminotransferase, cytoplasmic 2

1

0

High-throughput

0.458

High

762028

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

1

0

High-throughput

0.458

High

762031

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.458

High

762032

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.458

High

762034

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.458

High

762040

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.458

High

762044

SLD5
DNA replication complex GINS protein SLD5

1

0

High-throughput

0.458

High

762049

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

762050

PININ
Pinin

1

0

High-throughput

0.458

High

762054

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.458

High

762055

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.458

High

762059

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.458

High

762065

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.458

High

761964

ARRB1
Beta-arrestin-1

1

8

Small-scale

0.445

High

126064

AP3B1
AP-3 complex subunit beta-1

1

4

High-throughput

0.437

High

142865

NFIB
Nuclear factor 1 B-type

1

1

High-throughput

0.437

High

158781

AP3D1
AP-3 complex subunit delta-1

1

5

High-throughput

0.437

High

321896

FRYL
Protein furry homolog-like

1

1

High-throughput

0.437

High

405840

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.437

High

604608

UBF1
Nucleolar transcription factor 1

1

5

High-throughput

0.437

High

761961

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.437

High

761965

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.437

High

761966

AP3M2
AP-3 complex subunit mu-2

1

5

High-throughput

0.437

High

761967

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.437

High

761970

LYSC
Lysozyme C

1

1

High-throughput

0.437

High

762021

S31A7
Spermatogenesis-associated protein 31A7

1

1

High-throughput

0.437

High

762023

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

1

High-throughput

0.437

High

762053

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

12

High-throughput

0.437

High

762071

AP3M1
AP-3 complex subunit mu-1

1

5

High-throughput

0.437

High

552921

PIP
Prolactin-inducible protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025