HitPredict

Interactor 1: ACVL1 (P37023)
Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)
Gene: ACVRL1

Interactor 2: TGFR2 (P37173)
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Gene: TGFBR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.847

The method score is based on:

Property Details
Experiments 10187774, 23868260, 18333754
Identification Methods coimmunoprecipitation, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cross-linking study
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~TGF_beta_GS
Common GO terms GO:0001701 - in utero embryonic development
GO:0004675 - transmembrane receptor protein serine/threonine kinase activity
GO:0005024 - transforming growth factor beta receptor activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
and 10 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 503
Hs

1 567
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024