Protein: DDB2
DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2)

Gene: DDB2
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q92466

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000785 - chromatin
GO:0003684 - damaged DNA binding
GO:0003677 - DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1157835

DDB1
DNA damage-binding protein 1

40

20

Small-scale

0.995

High

1363085

DDA1
DET1- and DDB1-associated protein 1

4

2

High-throughput

0.900

High

1007174

TCPB
T-complex protein 1 subunit beta

4

20

High-throughput

0.805

High

1363081

TCPH
T-complex protein 1 subunit eta

4

20

High-throughput

0.805

High

882065

TCPG
T-complex protein 1 subunit gamma

3

20

High-throughput

0.770

High

1114964

CUL4A
Cullin-4A

32

20

Small-scale

0.769

High

876092

TCPE
T-complex protein 1 subunit epsilon

3

20

High-throughput

0.765

High

1115327

CUL4B
Cullin-4B

12

20

Small-scale

0.760

High

1363072

CSN5
COP9 signalosome complex subunit 5

12

10

Small-scale

0.758

High

1272503

CSN6
COP9 signalosome complex subunit 6

10

6

Small-scale

0.754

High

980062

H4
Histone H4

2

11

High-throughput

0.754

High

1363069

DDB2
DNA damage-binding protein 2

2

15

Small-scale

0.754

High

983908

RBX1
E3 ubiquitin-protein ligase RBX1

9

6

Small-scale

0.753

High

1363082

CSN4
COP9 signalosome complex subunit 4

8

2

Small-scale

0.748

High

1363101

CSN7A
COP9 signalosome complex subunit 7a

8

4

Small-scale

0.748

High

958683

CSN2
COP9 signalosome complex subunit 2

7

9

Small-scale

0.742

High

1363080

CSN8
COP9 signalosome complex subunit 8

7

2

Small-scale

0.742

High

1363108

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

8

Small-scale

0.740

High

1363107

CSN3
COP9 signalosome complex subunit 3

6

8

Small-scale

0.729

High

1032842

XPC
DNA repair protein complementing XP-C cells

5

3

Small-scale

0.714

High

1094387

CSN1
COP9 signalosome complex subunit 1

5

10

Small-scale

0.706

High

821482

TCPZ
T-complex protein 1 subunit zeta

2

20

High-throughput

0.705

High

332173

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

1

High-throughput

0.691

High

532817

CH60
60 kDa heat shock protein, mitochondrial

1

17

High-throughput

0.691

High

899503

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.691

High

1163099

H2B2E
Histone H2B type 2-E

1

19

High-throughput

0.691

High

1363087

PDCL3
Phosducin-like protein 3

1

8

High-throughput

0.691

High

1363078

PFD5
Prefoldin subunit 5

4

9

High-throughput

0.691

High

1363089

CSN7B
COP9 signalosome complex subunit 7b

4

4

High-throughput

0.691

High

1363092

PFD4
Prefoldin subunit 4

4

6

High-throughput

0.691

High

822787

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.665

High

1363104

PFD2
Prefoldin subunit 2

3

6

High-throughput

0.662

High

1162850

H2A2C
Histone H2A type 2-C

1

15

Small-scale

0.647

High

1258895

H32
Histone H3.2

1

20

Small-scale

0.647

High

1334300

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

3

0

High-throughput

0.638

High

1258065

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

1

Small-scale

0.637

High

133874

FOXN3
Forkhead box protein N3

2

10

High-throughput

0.628

High

1231211

TIGD3
Tigger transposable element-derived protein 3

2

4

High-throughput

0.628

High

1363097

GTSE1
G2 and S phase-expressed protein 1

2

1

High-throughput

0.628

High

1363102

APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2

2

1

High-throughput

0.628

High

610802

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.618

High

899157

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.618

High

1279436

WDR53
WD repeat-containing protein 53

1

17

High-throughput

0.618

High

1363070

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.618

High

419109

H2A1B
Histone H2A type 1-B/E

1

15

High-throughput

0.618

High

754923

H2B1B
Histone H2B type 1-B

1

19

High-throughput

0.618

High

957459

UBC12
NEDD8-conjugating enzyme Ubc12

1

12

High-throughput

0.618

High

998612

H31
Histone H3.1

1

20

Small-scale

0.618

High

1098362

ERCC8
DNA excision repair protein ERCC-8

1

17

Small-scale

0.618

High

1137422

SUZ12
Polycomb protein SUZ12

1

2

Small-scale

0.618

High

1155599

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

Small-scale

0.618

High

1340763

COP1
E3 ubiquitin-protein ligase COP1

1

18

High-throughput

0.618

High

1363088

WDR76
WD repeat-containing protein 76

1

18

High-throughput

0.618

High

1363091

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.618

High

1363095

DCA13
DDB1- and CUL4-associated factor 13

1

18

Small-scale

0.618

High

1363098

DTL
Denticleless protein homolog

1

16

Small-scale

0.618

High

1270314

SPT6H
Transcription elongation factor SPT6

2

7

High-throughput

0.611

High

1065010

FGL1
Fibrinogen-like protein 1

3

2

High-throughput

0.609

High

239160

ZNRD2
Protein ZNRD2

3

2

High-throughput

0.604

High

520230

ANDR
Androgen receptor

2

20

Small-scale

0.595

High

1363099

UVRAG
UV radiation resistance-associated gene protein

1

0

Small-scale

0.586

High

242445

PRKN
E3 ubiquitin-protein ligase parkin

2

12

High-throughput

0.584

High

1067549

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.584

High

1109942

HDAC1
Histone deacetylase 1

2

20

Small-scale

0.584

High

1029122

E2F1
Transcription factor E2F1

1

3

Small-scale

0.578

High

1329774

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

Small-scale

0.578

High

922393

CRBA4
Beta-crystallin A4

2

1

High-throughput

0.574

High

137544

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

19

Small-scale

0.561

High

654121

XPA
DNA repair protein complementing XP-A cells

1

1

Small-scale

0.561

High

1363077

DCR1C
Protein artemis

1

5

Small-scale

0.561

High

1363094

PDRG1
p53 and DNA damage-regulated protein 1

2

1

High-throughput

0.558

High

762030

GRK5
G protein-coupled receptor kinase 5

1

7

High-throughput

0.553

High

1144102

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

1287864

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

3

High-throughput

0.536

High

1323290

CCNQ
Cyclin-Q

1

4

High-throughput

0.536

High

1360271

CSN9
COP9 signalosome complex subunit 9

1

1

High-throughput

0.536

High

1363073

CUL5
Cullin-5

1

20

High-throughput

0.536

High

1363100

RBX2
RING-box protein 2

1

7

High-throughput

0.536

High

1363109

SMAG1
Protein Smaug homolog 1

1

1

High-throughput

0.536

High

317525

TPPP
Tubulin polymerization-promoting protein

1

1

High-throughput

0.515

High

1055949

RAD51
DNA repair protein RAD51 homolog 1

1

2

Small-scale

0.501

High

259014

DNJA2
DnaJ homolog subfamily A member 2

1

17

High-throughput

0.489

High

1197165

KHDC1
KH homology domain-containing protein 1

1

1

High-throughput

0.489

High

1200317

ANR39
Ankyrin repeat domain-containing protein 39

1

8

High-throughput

0.489

High

1363084

NTM1A
N-terminal Xaa-Pro-Lys N-methyltransferase 1

1

0

Small-scale

0.480

High

138733

IMA4
Importin subunit alpha-4

1

9

High-throughput

0.479

High

144305

ACACB
Acetyl-CoA carboxylase 2

1

20

High-throughput

0.479

High

260228

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

283613

SUPT3
Transcription initiation protein SPT3 homolog

1

2

Small-scale

0.479

High

332024

KAT7
Histone acetyltransferase KAT7

1

6

Small-scale

0.479

High

425586

ISG15
Ubiquitin-like protein ISG15

1

9

High-throughput

0.479

High

487585

PARP1
Poly [ADP-ribose] polymerase 1

1

12

Small-scale

0.479

High

542594

TOP2A
DNA topoisomerase 2-alpha

1

10

High-throughput

0.479

High

551179

PCNA
Proliferating cell nuclear antigen

1

2

Small-scale

0.479

High

558295

XRCC6
X-ray repair cross-complementing protein 6

1

7

Small-scale

0.479

High

559437

XRCC5
X-ray repair cross-complementing protein 5

1

7

Small-scale

0.479

High

573188

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.479

High

587752

DESP
Desmoplakin

1

20

High-throughput

0.479

High

589280

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

808130

CDN1A
Cyclin-dependent kinase inhibitor 1

1

2

Small-scale

0.479

High

894944

EMD
Emerin

1

3

Small-scale

0.479

High

934921

TERA
Transitional endoplasmic reticulum ATPase

1

7

Small-scale

0.479

High

943285

RBM11
Splicing regulator RBM11

1

12

High-throughput

0.479

High

965117

WDR5
WD repeat-containing protein 5

1

18

High-throughput

0.479

High

1004898

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

1039541

TOP2B
DNA topoisomerase 2-beta

1

10

High-throughput

0.479

High

1045583

TF65
Transcription factor p65

1

6

High-throughput

0.479

High

1098304

TBX2
T-box transcription factor TBX2

1

5

Small-scale

0.479

High

1363071

JARD2
Protein Jumonji

1

11

Small-scale

0.479

High

1363074

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

1

High-throughput

0.479

High

1363076

ZN512
Zinc finger protein 512

1

1

High-throughput

0.479

High

1363090

CLSPN
Claspin

1

7

Small-scale

0.479

High

1363093

TOPRS
E3 ubiquitin-protein ligase Topors

1

5

Small-scale

0.479

High

1363103

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1363110

CD11A
Cyclin-dependent kinase 11A

1

10

High-throughput

0.479

High

1363112

SP16H
FACT complex subunit SPT16

1

8

High-throughput

0.479

High

285700

BAF
Barrier-to-autointegration factor

1

0

Small-scale

0.458

High

1363083

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.458

High

1363086

CDT1
DNA replication factor Cdt1

1

0

Small-scale

0.458

High

91673

C9JFE4
COP9 signalosome complex subunit 1

1

7

High-throughput

0.445

High

95847

E7EM64
COP9 signalosome complex subunit 6

1

7

High-throughput

0.445

High

96940

E9PGT6
COP9 signalosome subunit 8

1

2

High-throughput

0.445

High

786191

LONM
Lon protease homolog, mitochondrial

1

12

High-throughput

0.445

High

911325

IMA5
Importin subunit alpha-5

1

9

High-throughput

0.445

High

939218

SUMO3
Small ubiquitin-related modifier 3

1

1

Small-scale

0.445

High

963341

PFD3
Prefoldin subunit 3

1

7

High-throughput

0.445

High

1244628

GASP3
G protein-coupled receptor associated sorting protein 3

1

1

High-throughput

0.445

High

1287682

RBM23
Probable RNA-binding protein 23

1

10

High-throughput

0.445

High

1363079

DNJC7
DnaJ homolog subfamily C member 7

1

17

High-throughput

0.445

High

1363106

CHIP
E3 ubiquitin-protein ligase CHIP

1

9

High-throughput

0.445

High

1363111

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

17

High-throughput

0.445

High

947242

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

1

High-throughput

0.437

High

1098817

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

8

Small-scale

0.437

High

1363105

HERC5
E3 ISG15--protein ligase HERC5

1

7

Small-scale

0.437

High

1219862

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.426

High

542136

TOP1
DNA topoisomerase 1

1

6

Small-scale

0.408

High

261847

PFD1
Prefoldin subunit 1

1

6

High-throughput

0.407

High

1094940

TRAF3
TNF receptor-associated factor 3

1

9

High-throughput

0.407

High

1363096

SPAT6
Spermatogenesis-associated protein 6

2

0

High-throughput

0.328

High

1247771

PAQR3
Progestin and adipoQ receptor family member 3

2

0

Small-scale

0.325

High

1329263

MET27
Methyltransferase-like protein 27

1

0

High-throughput

0.279

Low

1363075

P3IP1
Phosphoinositide-3-kinase-interacting protein 1

1

0

High-throughput

0.279

Low

60657

HYKK
Hydroxylysine kinase

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025